iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	4.10e-08	33.5	272	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaav 36
           +eta+e+++++FP+l+ys+++v+L++++  +++a+
   Q: 272  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQ 306
           89**************************9988887 PP

Organism

Rattus norvegicus

Functional Description
(View)

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity).

Protein Sequence
(Fasta)

MTEIPAPLSY FQNAQMSEDS HSSSVRSQND NQERQQHHDR QRLDNPESIS NGRPQSNFTR 60
QVIEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTGAGACC TCTAGGGCGG GGCCTAGGAC GACCTGCTCA GTGGGCCGCG AGTATTCGTC 60
GGAAACAAAA CAGCGGCAGC TGAGGCGGAA ACCTAGCTGC GAGCCGGCTG CCCGGGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0009986--C:cell surface
GO:0005813--C:centrosome
GO:0035253--C:ciliary rootlet
GO:0031410--C:cytoplasmic vesicle
GO:0043198--C:dendritic shaft
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0030426--C:growth cone
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005765--C:lysosomal membrane
GO:0045121--C:membrane raft
GO:0005743--C:mitochondrial inner membrane
GO:0005739--C:mitochondrion
GO:0031594--C:neuromuscular junction
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005640--C:nuclear outer membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0005791--C:rough endoplasmic reticulum
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0005262--F:calcium channel activity
GO:0004175--F:endopeptidase activity
GO:0008233--F:peptidase activity
GO:0000186--P:activation of MAPKK activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0042982--P:amyloid precursor protein metabolic process
GO:0000045--P:autophagosome assembly
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0001568--P:blood vessel development
GO:0048854--P:brain morphogenesis
GO:0021870--P:Cajal-Retzius cell differentiation
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0001708--P:cell fate specification
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0015871--P:choline transport
GO:0021904--P:dorsal/ventral neural tube patterning
GO:0030326--P:embryonic limb morphogenesis
GO:0050673--P:epithelial cell proliferation
GO:0042462--P:eye photoreceptor cell development
GO:0001947--P:heart looping
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0015813--P:L-glutamate transport
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007613--P:memory
GO:0006839--P:mitochondrial transport
GO:0043011--P:myeloid dendritic cell differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0050771--P:negative regulation of axonogenesis
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043524--P:negative regulation of neuron apoptotic process
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0003407--P:neural retina development
GO:0051402--P:neuron apoptotic process
GO:0001764--P:neuron migration
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0043085--P:positive regulation of catalytic activity
GO:0050820--P:positive regulation of coagulation
GO:0060999--P:positive regulation of dendritic spine development
GO:0043406--P:positive regulation of MAP kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001921--P:positive regulation of receptor recycling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006486--P:protein glycosylation
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0043393--P:regulation of protein binding
GO:0060075--P:regulation of resting membrane potential
GO:0048167--P:regulation of synaptic plasticity
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0006979--P:response to oxidative stress
GO:0016337--P:single organismal cell-cell adhesion
GO:0048705--P:skeletal system morphogenesis
GO:0043589--P:skin morphogenesis
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756--P:somitogenesis
GO:0016080--P:synaptic vesicle targeting
GO:0002286--P:T cell activation involved in immune response
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development

KEGG

rno:29192

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	35.41	3.00e-24	107.00
IUUC-Aml-001648	Ailuropoda melanoleuca	90.96	1.00e-160	558.00
IUUC-Atr-003039	Amborella trichopoda	32.74	6.00e-38	151.00
IUUC-Apl-003727	Anas platyrhynchos	79.62	9.00e-176	609.00
IUUC-Aca-004582	Anolis carolinensis	80.43	0.00e+00	639.00
IUUC-Aly-005455	Arabidopsis lyrata	32.09	6.00e-18	85.50
IUUC-Ath-006730	Arabidopsis thaliana	33.49	1.00e-18	87.80
IUUC-Ame-011500	Astyanax mexicanus	74.33	2.00e-150	525.00
IUUC-Bta-013026	Bos taurus	87.08	0.00e+00	687.00
IUUC-Bdi-014196	Brachypodium distachyon	33.24	3.00e-29	123.00
IUUC-Bol-015841	Brassica oleracea	34.92	2.00e-32	133.00
IUUC-Bra-017580	Brassica rapa	51.38	8.00e-18	84.70
IUUC-Cel-018553	Caenorhabditis elegans	52.30	2.00e-96	346.00
IUUC-Cja-019994	Callithrix jacchus	93.90	0.00e+00	670.00
IUUC-Cfa-020074	Canis familiaris	89.98	0.00e+00	702.00
IUUC-Cpo-022237	Cavia porcellus	92.06	0.00e+00	691.00
IUUC-Csa-023537	Chlorocebus sabaeus	92.32	0.00e+00	744.00
IUUC-Cho-024735	Choloepus hoffmanni	80.25	0.00e+00	645.00
IUUC-Cin-025780	Ciona intestinalis	63.50	5.00e-126	444.00
IUUC-Csv-025967	Ciona savignyi	62.72	1.00e-119	422.00
IUUC-Dre-028689	Danio rerio	78.20	8.00e-145	506.00
IUUC-Dno-029758	Dasypus novemcinctus	89.38	0.00e+00	696.00
IUUC-Dor-030609	Dipodomys ordii	72.92	2.00e-172	598.00
IUUC-Dme-031929	Drosophila melanogaster	54.27	2.00e-109	389.00
IUUC-Ete-032487	Echinops telfairi	80.09	5.00e-79	288.00
IUUC-Eeu-035134	Erinaceus europaeus	92.21	5.00e-145	506.00
IUUC-Fca-036243	Felis catus	89.98	0.00e+00	697.00
IUUC-Fal-036600	Ficedula albicollis	78.98	3.00e-175	607.00
IUUC-Gmo-039665	Gadus morhua	70.03	1.00e-114	406.00
IUUC-Gga-040993	Gallus gallus	80.00	7.00e-178	616.00
IUUC-Gac-042342	Gasterosteus aculeatus	67.98	1.00e-129	456.00
IUUC-Ggo-044859	Gorilla gorilla	91.40	4.00e-162	563.00
IUUC-Hsa-046822	Homo sapiens	92.32	0.00e+00	745.00
IUUC-Hvu-047141	Hordeum vulgare	36.07	2.00e-25	109.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	94.12	2.00e-156	544.00
IUUC-Lch-049946	Latimeria chalumnae	68.34	2.00e-142	499.00
IUUC-Loc-052469	Lepisosteus oculatus	63.43	5.00e-140	491.00
IUUC-Laf-053979	Loxodonta africana	86.55	2.00e-174	605.00
IUUC-Mcc-055682	Macaca mulatta	92.32	0.00e+00	745.00
IUUC-Meu-056004	Macropus eugenii	75.24	2.00e-151	528.00
IUUC-Mtr-058392	Medicago truncatula	33.70	3.00e-31	129.00
IUUC-Mga-059466	Meleagris gallopavo	80.00	1.00e-177	615.00
IUUC-Mmr-061538	Microcebus murinus	74.63	1.00e-156	545.00
IUUC-Mdo-062122	Monodelphis domestica	85.62	0.00e+00	671.00
IUUC-Mmu-063176	Mus musculus	95.95	0.00e+00	754.00
IUUC-Mpu-065927	Mustela putorius furo	88.68	0.00e+00	693.00
IUUC-Mlu-067079	Myotis lucifugus	89.36	0.00e+00	717.00
IUUC-Nle-070180	Nomascus leucogenys	92.32	0.00e+00	745.00
IUUC-Opr-070847	Ochotona princeps	86.36	0.00e+00	666.00
IUUC-Ont-071846	Oreochromis niloticus	76.69	1.00e-146	513.00
IUUC-Oan-072783	Ornithorhynchus anatinus	81.04	8.00e-130	456.00
IUUC-Ocu-074527	Oryctolagus cuniculus	91.24	0.00e+00	745.00
IUUC-Oba-075256	Oryza barthii	61.73	3.00e-16	79.30
IUUC-Olo-080484	Oryza longistaminata	61.73	1.00e-16	80.10
IUUC-Oar-090348	Ovis aries	88.94	0.00e+00	715.00
IUUC-Ptr-091060	Pan troglodytes	92.32	0.00e+00	745.00
IUUC-Pan-091855	Papio anubis	84.01	0.00e+00	645.00
IUUC-Psi-093505	Pelodiscus sinensis	80.43	2.00e-179	621.00
IUUC-Pfo-097396	Poecilia formosa	74.11	1.00e-152	533.00
IUUC-Pab-098591	Pongo abelii	91.45	0.00e+00	732.00
IUUC-Pop-099661	Populus trichocarpa	32.42	1.00e-33	137.00
IUUC-Pca-101029	Procavia capensis	84.93	0.00e+00	645.00
IUUC-Ppe-101495	Prunus persica	32.32	4.00e-38	152.00
IUUC-Pva-102244	Pteropus vampyrus	83.62	0.00e+00	647.00
IUUC-Sha-107045	Sarcophilus harrisii	86.44	0.00e+00	671.00
IUUC-Smo-109325	Selaginella moellendorffii	37.38	2.00e-36	146.00
IUUC-Sit-110624	Setaria italica	59.26	1.00e-15	77.80
IUUC-Stu-112433	Solanum tuberosum	34.91	6.00e-32	131.00
IUUC-Sar-113169	Sorex araneus	86.48	6.00e-141	493.00
IUUC-Sbi-114305	Sorghum bicolor	32.59	1.00e-24	107.00
IUUC-Ssc-115766	Sus scrofa	88.72	0.00e+00	687.00
IUUC-Tgu-116469	Taeniopygia guttata	86.18	1.00e-137	482.00
IUUC-Tru-117732	Takifugu rubripes	76.26	7.00e-144	503.00
IUUC-Tsy-119624	Tarsius syrichta	81.02	0.00e+00	640.00
IUUC-Tni-119852	Tetraodon nigroviridis	69.52	4.00e-136	478.00
IUUC-Tca-121865	Theobroma cacao	32.66	2.00e-37	150.00
IUUC-Tae-125925	Triticum aestivum	35.20	4.00e-26	112.00
IUUC-Tur-126237	Triticum urartu	35.53	2.00e-25	109.00
IUUC-Tbe-128148	Tupaia belangeri	83.33	2.00e-164	571.00
IUUC-Ttr-128793	Tursiops truncatus	87.87	0.00e+00	672.00
IUUC-Vpa-130625	Vicugna pacos	72.44	3.00e-152	531.00
IUUC-Vvi-131312	Vitis vinifera	33.42	9.00e-36	144.00
IUUC-Xtr-131790	Xenopus tropicalis	75.11	9.00e-157	546.00
IUUC-Xma-133377	Xiphophorus maculatus	74.11	7.00e-150	523.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence