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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-104826
Ensembl Protein ID ENSRNOP00000035416.4
UniProt Accession Q64232; TECR_RAT
Genbank Protein ID AAB23534.1; AAH59115.1
Protein Name Very-long-chain enoyl-CoA reductase; Synaptic glycoprotein SC2; Trans-2,3-enoyl-CoA reductase
Genbank Nucleotide ID S45663; BC059115
Gene Name Tecr; Gpsn2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000021808.4 ENSRNOT00000037608.4 ENSRNOP00000035416.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 41.73 4.00e-47 182.00 IUUC-Spo-108110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
 Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Protein Sequence
(Fasta)
MKHYEVEIRD AKTREKLCFL DKVEPQATIS EIKTLFTKTH PQWYPARQSL RLDPKGKSLK 60
DEDVLQKLPV GTTATLYFRD LGAQISWVTV FLTEYAGPLF IYLLFYFRVP FIYGRKYDFT 120
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Protein Fasta Sequence


>IUUC-Rno-104826|ULD,UBQ_Other|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
AGAAGGGACG CACGCATAGA GAGGGGCGGA GCCGGAGCCC TGGAGTGCTG CTCCTTGTGT 60
GTGTGGGGCT GGGTGGTGGT TGGTGCGGCA GGGCGGCTAC TCAGCTGCAG CAGTGCAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104826|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0325--Glycoprotein
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001104--3-oxo-5_a-steroid_4-DH_C
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50244--S5A_REDUCTASE
Pfam

PF02544--Steroid_dh
Gene Ontology

GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0016491--F:oxidoreductase activity
GO:0016627--F:oxidoreductase activity, acting on the CH-CH group of donors
GO:0030497--P:fatty acid elongation
GO:0006694--P:steroid biosynthetic process
GO:0042761--P:very long-chain fatty acid biosynthetic process
KEGG rno:191576
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000125 Aegilops tauschii 41.24 4.00e-51 194.00
IUUC-Aml-001579 Ailuropoda melanoleuca 80.44 2.00e-165 574.00
IUUC-Atr-002693 Amborella trichopoda 37.67 5.00e-41 161.00
IUUC-Apl-004113 Anas platyrhynchos 75.08 7.00e-143 499.00
IUUC-Aca-004681 Anolis carolinensis 89.61 7.00e-170 589.00
IUUC-Aly-005795 Arabidopsis lyrata 40.27 7.00e-49 187.00
IUUC-Ath-007255 Arabidopsis thaliana 39.26 2.00e-48 186.00
IUUC-Ago-007822 Ashbya gossypii 33.19 2.00e-27 115.00
IUUC-Acl-008131 Aspergillus clavatus 38.70 1.00e-34 140.00
IUUC-Afl-008670 Aspergillus flavus 35.71 5.00e-33 134.00
IUUC-Afu-009058 Aspergillus fumigatus 35.23 1.00e-33 136.00
IUUC-Ani-009299 Aspergillus nidulans 39.83 1.00e-36 146.00
IUUC-Ang-009520 Aspergillus niger 37.02 3.00e-35 142.00
IUUC-Aor-010023 Aspergillus oryzae 38.34 3.00e-39 155.00
IUUC-Ate-010593 Aspergillus terreus 37.04 2.00e-33 135.00
IUUC-Ame-011087 Astyanax mexicanus 85.71 8.00e-165 572.00
IUUC-Bgr-012251 Blumeria graminis 33.33 3.00e-37 148.00
IUUC-Bta-013170 Bos taurus 97.73 0.00e+00 630.00
IUUC-Bci-013894 Botrytis cinerea 33.45 1.00e-40 159.00
IUUC-Bdi-015014 Brachypodium distachyon 39.80 1.00e-48 186.00
IUUC-Bol-015761 Brassica oleracea 40.47 4.00e-49 188.00
IUUC-Bra-016894 Brassica rapa 39.93 1.00e-48 186.00
IUUC-Cel-018599 Caenorhabditis elegans 52.79 1.00e-89 322.00
IUUC-Cja-019333 Callithrix jacchus 93.42 5.00e-169 586.00
IUUC-Cfa-020709 Canis familiaris 96.39 5.00e-179 619.00
IUUC-Cpo-022353 Cavia porcellus 96.43 0.00e+00 626.00
IUUC-Cre-023020 Chlamydomonas reinhardtii 39.79 4.00e-50 191.00
IUUC-Csa-023716 Chlorocebus sabaeus 97.08 0.00e+00 626.00
IUUC-Csv-025915 Ciona savignyi 62.50 3.00e-114 404.00
IUUC-Cgl-026580 Colletotrichum gloeosporioides 35.36 1.00e-40 159.00
IUUC-Cne-027086 Cryptococcus neoformans 29.87 3.00e-24 105.00
IUUC-Cme-027185 Cyanidioschyzon merolae 43.33 9.00e-58 216.00
IUUC-Dre-028710 Danio rerio 85.06 4.00e-164 570.00
IUUC-Dno-029631 Dasypus novemcinctus 51.21 1.00e-85 309.00
IUUC-Dor-030220 Dipodomys ordii 97.40 0.00e+00 629.00
IUUC-Dse-031218 Dothistroma septosporum 36.92 3.00e-44 172.00
IUUC-Dme-031792 Drosophila melanogaster 52.79 6.00e-89 320.00
IUUC-Ete-032441 Echinops telfairi 86.10 4.00e-92 331.00
IUUC-Eca-033372 Equus caballus 96.75 0.00e+00 626.00
IUUC-Eeu-035351 Erinaceus europaeus 50.70 6.00e-65 240.00
IUUC-Fca-035630 Felis catus 97.05 6.00e-179 619.00
IUUC-Fal-037646 Ficedula albicollis 66.43 1.00e-111 395.00
IUUC-Fox-037721 Fusarium oxysporum 35.62 1.00e-39 156.00
IUUC-Fso-038379 Fusarium solani 33.56 1.00e-40 160.00
IUUC-Gmo-039616 Gadus morhua 73.86 6.00e-135 473.00
IUUC-Ggr-039727 Gaeumannomyces graminis 31.21 1.00e-30 127.00
IUUC-Gga-040786 Gallus gallus 71.17 4.00e-118 417.00
IUUC-Gac-041971 Gasterosteus aculeatus 79.22 3.00e-150 523.00
IUUC-Gma-043815 Glycine max 38.10 9.00e-42 163.00
IUUC-Ggo-045138 Gorilla gorilla 82.51 9.00e-141 492.00
IUUC-Hsa-045822 Homo sapiens 97.40 0.00e+00 627.00
IUUC-Hvu-047496 Hordeum vulgare 40.40 5.00e-51 194.00
IUUC-Itr-048022 Ictidomys tridecemlineatus 96.68 2.00e-158 550.00
IUUC-Kpa-049334 Komagataella pastoris 37.50 2.00e-32 132.00
IUUC-Lch-050175 Latimeria chalumnae 73.44 2.00e-142 498.00
IUUC-Lpe-051290 Leersia perrieri 39.35 1.00e-49 189.00
IUUC-Loc-052055 Lepisosteus oculatus 86.36 5.00e-165 573.00
IUUC-Lma-053284 Leptosphaeria maculans 38.30 8.00e-38 150.00
IUUC-Laf-053677 Loxodonta africana 95.41 2.00e-176 610.00
IUUC-Mcc-055371 Macaca mulatta 91.45 1.00e-164 572.00
IUUC-Meu-056786 Macropus eugenii 82.14 4.00e-149 520.00
IUUC-Mor-057062 Magnaporthe oryzae 30.23 6.00e-30 124.00
IUUC-Mpo-057319 Magnaporthe poae 28.90 5.00e-30 124.00
IUUC-Mtr-058159 Medicago truncatula 38.10 4.00e-42 165.00
IUUC-Mla-058998 Melampsora laricipopulina 33.24 1.00e-38 153.00
IUUC-Mga-059715 Meleagris gallopavo 75.08 3.00e-143 500.00
IUUC-Mvi-060498 Microbotryum violaceum 44.80 6.00e-44 171.00
IUUC-Mmr-061604 Microcebus murinus 96.10 5.00e-180 623.00
IUUC-Mdo-062723 Monodelphis domestica 93.11 4.00e-173 600.00
IUUC-Mmu-064423 Mus musculus 94.16 9.00e-172 595.00
IUUC-Mac-064557 Musa acuminata 36.05 6.00e-43 167.00
IUUC-Mpu-065790 Mustela putorius furo 97.08 0.00e+00 626.00
IUUC-Mlu-067323 Myotis lucifugus 96.07 8.00e-178 615.00
IUUC-Nfi-068303 Neosartorya fischeri 38.31 2.00e-34 139.00
IUUC-Ncr-068930 Neurospora crassa 32.59 3.00e-33 135.00
IUUC-Nle-069641 Nomascus leucogenys 97.08 0.00e+00 626.00
IUUC-Opr-070264 Ochotona princeps 49.46 1.00e-51 196.00
IUUC-Ont-072619 Oreochromis niloticus 85.39 1.00e-163 568.00
IUUC-Oan-072871 Ornithorhynchus anatinus 92.53 2.00e-174 604.00
IUUC-Ocu-074116 Oryctolagus cuniculus 50.65 3.00e-90 325.00
IUUC-Oba-075519 Oryza barthii 39.00 5.00e-50 191.00
IUUC-Obr-076026 Oryza brachyantha 39.60 7.00e-51 194.00
IUUC-Ogl-077299 Oryza glaberrima 39.39 2.00e-50 192.00
IUUC-Ogu-078328 Oryza glumaepatula 40.15 4.00e-50 191.00
IUUC-Oin-079058 Oryza indica 39.39 2.00e-50 192.00
IUUC-Olo-080760 Oryza longistaminata 39.76 4.00e-45 175.00
IUUC-Ome-081290 Oryza meridionalis 39.00 5.00e-50 191.00
IUUC-Oni-082116 Oryza nivara 39.27 8.00e-50 191.00
IUUC-Opu-083484 Oryza punctata 40.15 2.00e-49 189.00
IUUC-Oru-085234 Oryza rufipogon 39.27 8.00e-50 191.00
IUUC-Osa-085723 Oryza sativa 39.39 2.00e-50 192.00
IUUC-Ola-087142 Oryzias latipes 85.71 4.00e-164 570.00
IUUC-Olu-087663 Ostreococcus lucimarinus 39.93 8.00e-52 197.00
IUUC-Oga-088511 Otolemur garnettii 96.39 5.00e-178 616.00
IUUC-Oar-090337 Ovis aries 72.22 3.00e-119 421.00
IUUC-Ptr-090829 Pan troglodytes 97.03 4.00e-177 613.00
IUUC-Pan-091853 Papio anubis 96.60 6.00e-154 536.00
IUUC-Psi-093244 Pelodiscus sinensis 92.22 2.00e-142 498.00
IUUC-Pno-094768 Phaeosphaeria nodorum 38.61 4.00e-42 166.00
IUUC-Ppa-095402 Physcomitrella patens 37.58 2.00e-47 182.00
IUUC-Pfo-096308 Poecilia formosa 85.71 2.00e-164 570.00
IUUC-Pab-098622 Pongo abelii 96.85 5.00e-148 516.00
IUUC-Pop-099770 Populus trichocarpa 38.68 6.00e-45 174.00
IUUC-Pca-100732 Procavia capensis 93.73 6.00e-170 589.00
IUUC-Ppe-102094 Prunus persica 38.44 3.00e-49 188.00
IUUC-Pva-103208 Pteropus vampyrus 96.43 3.00e-180 624.00
IUUC-Pgr-103639 Puccinia graminis 29.81 4.00e-26 112.00
IUUC-Ptt-103851 Puccinia triticina 33.66 1.00e-33 136.00
IUUC-Pte-104134 Pyrenophora teres 41.91 2.00e-41 162.00
IUUC-Pyt-104660 Pyrenophora triticirepentis 42.80 1.00e-41 162.00
IUUC-Sce-106237 Saccharomyces cerevisiae 32.57 2.00e-27 116.00
IUUC-Sha-107453 Sarcophilus harrisii 93.42 2.00e-172 597.00
IUUC-Sja-107686 Schizosaccharomyces japonicus 41.38 2.00e-47 182.00
IUUC-Spo-108110 Schizosaccharomyces pombe 41.73 2.00e-47 182.00
IUUC-Smo-108765 Selaginella moellendorffii 37.81 5.00e-48 184.00
IUUC-Sit-110416 Setaria italica 39.33 3.00e-50 192.00
IUUC-Sly-111184 Solanum lycopersicum 39.13 4.00e-51 194.00
IUUC-Stu-112187 Solanum tuberosum 38.33 7.00e-51 194.00
IUUC-Sar-113576 Sorex araneus 45.00 1.00e-27 117.00
IUUC-Sbi-114251 Sorghum bicolor 39.00 1.00e-49 190.00
IUUC-Sre-114975 Sporisorium reilianum 41.92 1.00e-56 213.00
IUUC-Ssc-115522 Sus scrofa 98.15 5.00e-159 553.00
IUUC-Tgu-116610 Taeniopygia guttata 72.37 4.00e-136 477.00
IUUC-Tru-118204 Takifugu rubripes 83.93 5.00e-161 560.00
IUUC-Tsy-119153 Tarsius syrichta 43.79 4.00e-75 275.00
IUUC-Tni-119738 Tetraodon nigroviridis 83.50 8.00e-161 559.00
IUUC-Tca-120950 Theobroma cacao 38.29 3.00e-50 192.00
IUUC-Tre-122109 Trichoderma reesei 35.99 8.00e-41 160.00
IUUC-Tvi-122473 Trichoderma virens 36.05 2.00e-42 166.00
IUUC-Tae-123617 Triticum aestivum 40.27 3.00e-51 195.00
IUUC-Tur-126035 Triticum urartu 43.70 4.00e-46 178.00
IUUC-Tme-127040 Tuber melanosporum 31.21 4.00e-35 142.00
IUUC-Tbe-127888 Tupaia belangeri 45.52 7.00e-36 144.00
IUUC-Ttr-128486 Tursiops truncatus 97.08 0.00e+00 625.00
IUUC-Uma-129516 Ustilago maydis 40.14 1.00e-52 200.00
IUUC-Vda-129861 Verticillium dahliae 37.10 1.00e-34 139.00
IUUC-Vpa-130704 Vicugna pacos 45.10 9.00e-80 290.00
IUUC-Vvi-131375 Vitis vinifera 38.17 7.00e-51 194.00
IUUC-Xtr-132795 Xenopus tropicalis 88.64 1.00e-168 585.00
IUUC-Xma-133866 Xiphophorus maculatus 85.39 5.00e-164 569.00
IUUC-Yli-134568 Yarrowia lipolytica 33.86 6.00e-42 164.00
IUUC-Zma-134891 Zea mays 38.83 2.00e-49 189.00
Created Date 25-Jun-2017

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