iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055083

Ensembl Protein ID

ENSMMUP00000023000.2

UniProt Accession

F6VIL8; F6VIL8_MACMU

Genbank Protein ID

ENSMMUP00000023000

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

JSUE03007898

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000017475.3	ENSMMUT00000024573.3	ENSMMUP00000023000.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.10e-13	50.1	436	467
UBD/Beta-Prp	9.90e-44	150.8	204	506

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           tc+++  s  +l+vsG+ Dg +++ Dlr+g+ 
   Q: 436  TCVNLsdSPpNLMVSGNMDGRVRIHDLRSGNI 467
           89999873359*****************9975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+t
   Q: 204  ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRT 288
           567778999998888..9***********************9999777777789999999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v+ ++ + ++ + lk ++ 
   Q: 289  GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPSEEGYWQIAAEFEVPKLVQYLEIVPETgRYPVAVAAAGDLM-YLLKAEDS 376
           ***999999********************************************************99************8.******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl  +h ++v++l+++ n+     + l ++ + +++ +++l++g+ + +l +  + +++v++s +  +++vsg++Dg +ri+dlrsg
   Q: 377  ARTLLYAHGPPVTCLDVSANQvafgvQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSdSPPNLMVSGNMDGRVRIHDLRSG 465
           *****************************************************************78899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+  v++v++   +d+++v+g+e++ v +w++++n+
   Q: 466  NIALSLSAHQLGVSAVQM---DDWKIVSGGEEGLVSVWDYRTNQ 506
           **********99999999...*******************9987 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MDDCSLDEFR RRWQEELAQA QAPRKRRRPE AAERWARRPE VVPGRGEQAS GDPALAQGLL 60
EGAGRPPAAR ATRTEGQDVA SRSRSPLARE GAGGGEQLVD QLIRDLNEMN DVPFFDIQLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCACCCGG AACCCTAGAG CTGCGGCAAC AGCGGCTTCC GGCCGCGGCG GACACTTCCG 60
TGGAAGGGAC TGTCCCGTGG CACCCGGTGG AACCGAGGAG AACGTGGAGC GCCGGGAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

KEGG

mcc:693388

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	88.42	0.00e+00	947.00
IUUC-Apl-003239	Anas platyrhynchos	59.35	0.00e+00	672.00
IUUC-Aca-004756	Anolis carolinensis	57.39	1.00e-127	449.00
IUUC-Ame-011198	Astyanax mexicanus	41.36	2.00e-58	219.00
IUUC-Bta-012430	Bos taurus	61.25	6.00e-158	550.00
IUUC-Cja-019131	Callithrix jacchus	89.97	0.00e+00	1032.00
IUUC-Cfa-021022	Canis familiaris	79.53	0.00e+00	923.00
IUUC-Cpo-021898	Cavia porcellus	77.85	0.00e+00	905.00
IUUC-Csa-023452	Chlorocebus sabaeus	99.00	0.00e+00	1157.00
IUUC-Cho-024759	Choloepus hoffmanni	75.92	0.00e+00	838.00
IUUC-Dre-028123	Danio rerio	42.28	2.00e-142	499.00
IUUC-Dno-029045	Dasypus novemcinctus	87.53	0.00e+00	832.00
IUUC-Dor-030433	Dipodomys ordii	78.00	0.00e+00	774.00
IUUC-Ete-032465	Echinops telfairi	81.02	0.00e+00	746.00
IUUC-Eca-034134	Equus caballus	87.40	0.00e+00	900.00
IUUC-Eeu-035047	Erinaceus europaeus	77.14	0.00e+00	771.00
IUUC-Fca-036574	Felis catus	87.50	0.00e+00	884.00
IUUC-Fal-037665	Ficedula albicollis	59.28	3.00e-170	591.00
IUUC-Gmo-039137	Gadus morhua	41.10	4.00e-70	258.00
IUUC-Gga-040711	Gallus gallus	58.86	0.00e+00	660.00
IUUC-Gac-041675	Gasterosteus aculeatus	49.47	1.00e-49	189.00
IUUC-Ggo-045331	Gorilla gorilla	98.37	0.00e+00	1009.00
IUUC-Hsa-046240	Homo sapiens	97.66	0.00e+00	1127.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	88.62	0.00e+00	885.00
IUUC-Loc-052631	Lepisosteus oculatus	48.70	1.00e-164	573.00
IUUC-Laf-054127	Loxodonta africana	72.73	1.00e-55	208.00
IUUC-Mga-060113	Meleagris gallopavo	62.02	0.00e+00	643.00
IUUC-Mmr-061780	Microcebus murinus	86.48	0.00e+00	921.00
IUUC-Mdo-063066	Monodelphis domestica	59.80	0.00e+00	706.00
IUUC-Mmu-063524	Mus musculus	77.09	0.00e+00	839.00
IUUC-Mpu-066913	Mustela putorius furo	88.42	0.00e+00	922.00
IUUC-Mlu-067924	Myotis lucifugus	84.92	0.00e+00	931.00
IUUC-Nle-069558	Nomascus leucogenys	96.16	0.00e+00	1041.00
IUUC-Opr-070506	Ochotona princeps	84.51	0.00e+00	906.00
IUUC-Ont-071514	Oreochromis niloticus	45.36	5.00e-143	501.00
IUUC-Ocu-074477	Oryctolagus cuniculus	85.36	0.00e+00	865.00
IUUC-Ola-087416	Oryzias latipes	44.25	4.00e-146	511.00
IUUC-Oga-088643	Otolemur garnettii	87.46	0.00e+00	940.00
IUUC-Oar-090172	Ovis aries	86.48	0.00e+00	882.00
IUUC-Ptr-090870	Pan troglodytes	97.83	0.00e+00	1124.00
IUUC-Pan-092017	Papio anubis	98.66	0.00e+00	1157.00
IUUC-Psi-093794	Pelodiscus sinensis	63.23	0.00e+00	650.00
IUUC-Pfo-096192	Poecilia formosa	49.71	3.00e-145	508.00
IUUC-Pab-097882	Pongo abelii	96.66	0.00e+00	1104.00
IUUC-Pca-100902	Procavia capensis	85.16	7.00e-157	547.00
IUUC-Pva-103139	Pteropus vampyrus	85.64	0.00e+00	958.00
IUUC-Rno-105798	Rattus norvegicus	80.08	0.00e+00	849.00
IUUC-Sha-106576	Sarcophilus harrisii	64.75	0.00e+00	664.00
IUUC-Ssc-115923	Sus scrofa	76.72	0.00e+00	915.00
IUUC-Tgu-116667	Taeniopygia guttata	53.07	2.00e-107	382.00
IUUC-Tru-118323	Takifugu rubripes	42.93	9.00e-137	480.00
IUUC-Tsy-118818	Tarsius syrichta	70.47	5.00e-98	351.00
IUUC-Tni-120438	Tetraodon nigroviridis	42.49	2.00e-135	476.00
IUUC-Tbe-127784	Tupaia belangeri	83.98	2.00e-98	352.00
IUUC-Ttr-128288	Tursiops truncatus	78.82	0.00e+00	816.00
IUUC-Vpa-130307	Vicugna pacos	84.39	0.00e+00	801.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence