iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066647

Ensembl Protein ID

ENSMPUP00000000622.1

UniProt Accession

M3XNH2; M3XNH2_MUSPF

Genbank Protein ID

ENSMPUP00000000622

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01047163

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000000628.1	ENSMPUT00000000634.1	ENSMPUP00000000622.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-100	336.8	74	425

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 74   TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 162
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 163  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSALSA-SNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 250
           *****************************775555555554444444444.4688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 251  PFLDLSLDIPSQFRNKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 337
           **********66655444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++e++v++   ++aY+lf
   Q: 338  KVDTYVEFPLRgLDMKCYLLEPENSGPEHCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEDTVVK---AKAYILF 422
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 423  YVE 425
           *76 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MDCSSYSTYC YRCDDFVVND TKLGLVQKVR EHLQNLENSA FTADRHRKRK LLENSSLNSK 60
LLKVNGSTAA ICATGLRNLG NTCFMNAILQ SLSNIEQFCC YFKELPAVEL RNGKTAGRRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATATATATA TGAATCTTAC ATTGCATATA CTTACTATTG TTTTGCAATA ATAGTTGTGT 60
GGTATTTACA TTTATGACCT ATTATTTCTT TTGAAGGTGC TGCTACTGTT TAACCATATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	99.08	0.00e+00	788.00
IUUC-Apl-003358	Anas platyrhynchos	96.32	0.00e+00	788.00
IUUC-Aca-004454	Anolis carolinensis	94.15	0.00e+00	707.00
IUUC-Ame-011544	Astyanax mexicanus	77.55	6.00e-173	600.00
IUUC-Bta-012738	Bos taurus	98.16	0.00e+00	764.00
IUUC-Cel-018186	Caenorhabditis elegans	37.08	2.00e-55	209.00
IUUC-Cja-018893	Callithrix jacchus	97.70	0.00e+00	769.00
IUUC-Cfa-020607	Canis familiaris	99.77	0.00e+00	774.00
IUUC-Cpo-021828	Cavia porcellus	96.32	0.00e+00	747.00
IUUC-Csa-023884	Chlorocebus sabaeus	98.59	0.00e+00	779.00
IUUC-Cho-024863	Choloepus hoffmanni	91.72	0.00e+00	699.00
IUUC-Dre-028452	Danio rerio	75.40	4.00e-180	624.00
IUUC-Dno-029531	Dasypus novemcinctus	97.93	0.00e+00	762.00
IUUC-Dor-030913	Dipodomys ordii	87.86	3.00e-143	501.00
IUUC-Ete-032611	Echinops telfairi	90.80	0.00e+00	702.00
IUUC-Eca-033622	Equus caballus	99.08	0.00e+00	768.00
IUUC-Eeu-035268	Erinaceus europaeus	92.41	0.00e+00	691.00
IUUC-Fca-035801	Felis catus	98.85	0.00e+00	800.00
IUUC-Fal-036749	Ficedula albicollis	95.17	0.00e+00	741.00
IUUC-Gmo-039598	Gadus morhua	78.87	0.00e+00	639.00
IUUC-Gga-040883	Gallus gallus	96.55	0.00e+00	754.00
IUUC-Gac-042235	Gasterosteus aculeatus	80.23	0.00e+00	644.00
IUUC-Ggo-044767	Gorilla gorilla	91.74	0.00e+00	724.00
IUUC-Hsa-046581	Homo sapiens	98.16	0.00e+00	796.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	98.39	0.00e+00	763.00
IUUC-Lch-049732	Latimeria chalumnae	92.61	0.00e+00	764.00
IUUC-Loc-052371	Lepisosteus oculatus	90.76	0.00e+00	752.00
IUUC-Laf-054565	Loxodonta africana	98.16	0.00e+00	762.00
IUUC-Mcc-055522	Macaca mulatta	98.62	0.00e+00	799.00
IUUC-Meu-056754	Macropus eugenii	84.59	3.00e-128	451.00
IUUC-Mga-060095	Meleagris gallopavo	95.39	2.00e-151	528.00
IUUC-Mmr-060839	Microcebus murinus	98.39	0.00e+00	761.00
IUUC-Mdo-062339	Monodelphis domestica	97.47	0.00e+00	760.00
IUUC-Mmu-063638	Mus musculus	96.55	0.00e+00	731.00
IUUC-Mlu-067921	Myotis lucifugus	97.01	0.00e+00	779.00
IUUC-Nle-069752	Nomascus leucogenys	98.62	0.00e+00	800.00
IUUC-Opr-070636	Ochotona princeps	85.06	2.00e-177	615.00
IUUC-Ont-071638	Oreochromis niloticus	79.03	0.00e+00	667.00
IUUC-Oan-073417	Ornithorhynchus anatinus	90.11	0.00e+00	721.00
IUUC-Ocu-074620	Oryctolagus cuniculus	96.32	0.00e+00	748.00
IUUC-Ola-087281	Oryzias latipes	79.03	0.00e+00	632.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.00	6.00e-49	187.00
IUUC-Oga-088448	Otolemur garnettii	97.70	0.00e+00	791.00
IUUC-Oar-090132	Ovis aries	98.16	0.00e+00	764.00
IUUC-Ptr-090696	Pan troglodytes	98.39	0.00e+00	798.00
IUUC-Pan-092124	Papio anubis	98.16	0.00e+00	794.00
IUUC-Psi-093801	Pelodiscus sinensis	96.55	0.00e+00	754.00
IUUC-Pma-094300	Petromyzon marinus	71.54	3.00e-99	354.00
IUUC-Pfo-096330	Poecilia formosa	80.41	0.00e+00	654.00
IUUC-Pab-098191	Pongo abelii	98.62	0.00e+00	800.00
IUUC-Pca-100341	Procavia capensis	96.88	4.00e-158	551.00
IUUC-Pva-103177	Pteropus vampyrus	98.39	0.00e+00	752.00
IUUC-Rno-105048	Rattus norvegicus	96.55	0.00e+00	730.00
IUUC-Sha-107429	Sarcophilus harrisii	97.47	0.00e+00	758.00
IUUC-Sar-113024	Sorex araneus	97.01	0.00e+00	755.00
IUUC-Ssc-115749	Sus scrofa	96.44	8.00e-152	529.00
IUUC-Tgu-117277	Taeniopygia guttata	95.40	0.00e+00	779.00
IUUC-Tru-117844	Takifugu rubripes	81.11	0.00e+00	657.00
IUUC-Tsy-119456	Tarsius syrichta	95.40	0.00e+00	756.00
IUUC-Tni-120251	Tetraodon nigroviridis	76.78	0.00e+00	673.00
IUUC-Tbe-127423	Tupaia belangeri	90.11	0.00e+00	677.00
IUUC-Ttr-128401	Tursiops truncatus	90.80	0.00e+00	683.00
IUUC-Vpa-130549	Vicugna pacos	89.29	2.00e-137	481.00
IUUC-Xtr-131892	Xenopus tropicalis	83.48	0.00e+00	654.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence