iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000019055.2	ENSLACT00000021827.2	ENSLACP00000021686.2
ENSLACG00000019055.2	ENSLACT00000021828.1	ENSLACP00000021687.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.70e-135	449.8	547	879

Active Site

Position(s)	Description	Evidence
848	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 547  PQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 634
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl +iken   +iee+gl++ fsv++eilge+k+++Lk++G+ni Vt+eNkeeY++lv+e
   Q: 635  GFSLPFYKRILNKSVGLKDLESIDPEFYNSLIWIKEN---NIEECGLEMYFSVDKEILGEVKTHDLKSDGSNILVTEENKEEYIRLVAE 720
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+l+cG++eid++d++++t y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 721  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHTIYRH-YTRTSKQIVWFWQFIKEIDNEKRMRLLQFV 808
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           T ++rlP+gGf +l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 809  TATCRLPVGGFSDLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 879
           *********************************************************************96 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MACGRSRSGS PNGYTMKSQL QITVLSAKLR ENKKNWFGPS PYVEVAVDGQ SKKTEKCMNT 60
HSPKWKQSLT VIVTPYSKLN FRVWSHQTLK SDALLGKATL NIYDTLKSNN MKIEEVVATL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACGGGAGTC ACTGTGAAGA TGGTGGAAGT TTCGTTGAAG TGGCTGTGGA ACTCCGGGAT 60
GTGAAATTGG CCGCCGAGGA AATAGCTGAC AGCTTCAGAG AAGACGGGAG TTCCAGGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

lcm:102365782

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	78.43	0.00e+00	1378.00
IUUC-Apl-003752	Anas platyrhynchos	78.21	0.00e+00	1376.00
IUUC-Aca-005338	Anolis carolinensis	91.48	0.00e+00	1157.00
IUUC-Ago-007742	Ashbya gossypii	49.31	1.00e-160	560.00
IUUC-Ame-010601	Astyanax mexicanus	88.72	0.00e+00	1121.00
IUUC-Bta-012782	Bos taurus	92.84	0.00e+00	1150.00
IUUC-Cja-018899	Callithrix jacchus	88.91	0.00e+00	1159.00
IUUC-Cfa-020648	Canis familiaris	77.36	0.00e+00	1341.00
IUUC-Cpo-022073	Cavia porcellus	78.21	0.00e+00	1400.00
IUUC-Csa-023252	Chlorocebus sabaeus	77.53	0.00e+00	1389.00
IUUC-Cho-024695	Choloepus hoffmanni	72.23	0.00e+00	1326.00
IUUC-Cne-026849	Cryptococcus neoformans	48.14	6.00e-160	557.00
IUUC-Dre-028451	Danio rerio	73.73	0.00e+00	1308.00
IUUC-Dno-029884	Dasypus novemcinctus	77.19	0.00e+00	1384.00
IUUC-Eca-033793	Equus caballus	77.87	0.00e+00	1384.00
IUUC-Eeu-034716	Erinaceus europaeus	87.99	0.00e+00	852.00
IUUC-Fca-035605	Felis catus	78.89	0.00e+00	1395.00
IUUC-Fal-037126	Ficedula albicollis	91.99	0.00e+00	1174.00
IUUC-Gmo-038596	Gadus morhua	80.24	0.00e+00	1002.00
IUUC-Gga-040832	Gallus gallus	77.22	0.00e+00	1380.00
IUUC-Gac-041658	Gasterosteus aculeatus	86.12	0.00e+00	1114.00
IUUC-Ggo-044535	Gorilla gorilla	74.80	0.00e+00	1340.00
IUUC-Hsa-046564	Homo sapiens	74.78	0.00e+00	1375.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	89.57	0.00e+00	1159.00
IUUC-Kpa-049273	Komagataella pastoris	49.05	6.00e-163	567.00
IUUC-Loc-052647	Lepisosteus oculatus	73.70	0.00e+00	1360.00
IUUC-Laf-054383	Loxodonta africana	78.09	0.00e+00	1399.00
IUUC-Mcc-055532	Macaca mulatta	77.53	0.00e+00	1389.00
IUUC-Mga-059661	Meleagris gallopavo	77.44	0.00e+00	1374.00
IUUC-Mmr-061135	Microcebus murinus	78.15	0.00e+00	1400.00
IUUC-Mdo-062505	Monodelphis domestica	92.52	0.00e+00	1176.00
IUUC-Mmu-063375	Mus musculus	90.07	0.00e+00	1169.00
IUUC-Mpu-066203	Mustela putorius furo	78.55	0.00e+00	1377.00
IUUC-Mlu-067837	Myotis lucifugus	77.98	0.00e+00	1384.00
IUUC-Nle-069244	Nomascus leucogenys	77.53	0.00e+00	1377.00
IUUC-Opr-070585	Ochotona princeps	90.57	0.00e+00	1157.00
IUUC-Ont-071798	Oreochromis niloticus	88.78	0.00e+00	1137.00
IUUC-Ocu-074298	Oryctolagus cuniculus	78.48	0.00e+00	1397.00
IUUC-Ola-086526	Oryzias latipes	84.65	0.00e+00	1106.00
IUUC-Oga-088167	Otolemur garnettii	73.68	0.00e+00	1279.00
IUUC-Oar-090316	Ovis aries	70.86	0.00e+00	810.00
IUUC-Ptr-090819	Pan troglodytes	74.07	0.00e+00	1335.00
IUUC-Pan-092454	Papio anubis	77.53	0.00e+00	1388.00
IUUC-Psi-093319	Pelodiscus sinensis	78.60	0.00e+00	1350.00
IUUC-Pfo-096937	Poecilia formosa	88.89	0.00e+00	1120.00
IUUC-Pab-097580	Pongo abelii	69.05	0.00e+00	1229.00
IUUC-Pca-100923	Procavia capensis	77.99	0.00e+00	1034.00
IUUC-Pva-103209	Pteropus vampyrus	77.39	0.00e+00	1321.00
IUUC-Rno-104924	Rattus norvegicus	89.56	0.00e+00	1173.00
IUUC-Sha-107175	Sarcophilus harrisii	89.36	0.00e+00	1181.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.71	5.00e-160	558.00
IUUC-Sar-113761	Sorex araneus	92.50	0.00e+00	1144.00
IUUC-Tgu-116632	Taeniopygia guttata	75.23	0.00e+00	1270.00
IUUC-Tru-118442	Takifugu rubripes	89.08	0.00e+00	1114.00
IUUC-Tsy-119198	Tarsius syrichta	71.70	0.00e+00	1257.00
IUUC-Tni-120168	Tetraodon nigroviridis	86.80	0.00e+00	1058.00
IUUC-Tbe-127756	Tupaia belangeri	70.44	0.00e+00	894.00
IUUC-Ttr-128504	Tursiops truncatus	68.72	0.00e+00	947.00
IUUC-Vpa-130103	Vicugna pacos	77.09	0.00e+00	979.00
IUUC-Xtr-132885	Xenopus tropicalis	90.50	0.00e+00	1172.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence