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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063741
Ensembl Protein ID ENSMUSP00000129584.2
UniProt Accession Q61140; Q60869; Q6PFF9; BCAR1_MOUSE
Genbank Protein ID AAA93381.1; AAA93248.1; BAE26705.1; AAH57578.1
Protein Name Breast cancer anti-estrogen resistance protein 1; CRK-associated substrate; p130cas
Genbank Nucleotide ID U48853; U28151; AK145863; BC057578
Gene Name Bcar1; Cas; Crkas
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031955.10 ENSMUST00000166232.3 ENSMUSP00000129584.2
ENSMUSG00000031955.10 ENSMUST00000212349.1 ENSMUSP00000148364.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.10e-10 42.4 8 58
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeq.degWlkgvkelegkrGlfPen 57
            ++lyd  a++ deL+++kGd+++v+e ++q   gW+ +   l+g++G++P n
   Q: 8    AKALYDNVAESPDELSFRKGDIMTVLERDTQgLDGWWLC--SLHGRQGIVPGN 58
           589***********************55555168*****..9*********98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity). Has been shown to be essential in cardiovascular development during embryogenesis.
 Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity). Has been shown to be essential in cardiovascular development during embryogenesis.
Protein Sequence
(Fasta)
MTVPNVLAKA LYDNVAESPD ELSFRKGDIM TVLERDTQGL DGWWLCSLHG RQGIVPGNRL 60
KILVGMYDKK PVGPGPGPPA TPPQPQPSLP QGVHAPVPPA SQYSPMLPTA YQPQSDNVYL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063741|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGCGGAGAA CGCCGGGACC CCGCGCCGGG GGCTGTGAGC GGCGCGGGCC CACCGAGCCC 60
GAGCTAGCCC GCGCCGCTGC TGCAGGGCTC CGGGGGGGCG GCGGCCAAGA TGACCGTGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063741|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0729--SH3-binding
Interpro

IPR028848--BCAR1
IPR021901--CAS_DUF3513
IPR014928--Serine_rich
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
IPR015224--Talin_cent
PROSITE

PS50002--SH3
Pfam

PF12026--DUF3513
PF08824--Serine_rich
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA
SMART

SM00326--SH3
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0019901--F:protein kinase binding
GO:0004871--F:signal transducer activity
GO:0007015--P:actin filament organization
GO:0050851--P:antigen receptor-mediated signaling pathway
GO:0050853--P:B cell receptor signaling pathway
GO:0007155--P:cell adhesion
GO:0060326--P:cell chemotaxis
GO:0016477--P:cell migration
GO:0035729--P:cellular response to hepatocyte growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0048012--P:hepatocyte growth factor receptor signaling pathway
GO:0008286--P:insulin receptor signaling pathway
GO:0007229--P:integrin-mediated signaling pathway
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:0010595--P:positive regulation of endothelial cell migration
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
KEGG mmu:12927
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001208 Ailuropoda melanoleuca 88.10 0.00e+00 1159.00
IUUC-Apl-003391 Anas platyrhynchos 37.74 6.00e-138 484.00
IUUC-Aca-004548 Anolis carolinensis 39.47 1.00e-142 500.00
IUUC-Bta-013197 Bos taurus 81.83 0.00e+00 1137.00
IUUC-Cja-018921 Callithrix jacchus 90.57 0.00e+00 1332.00
IUUC-Cfa-020772 Canis familiaris 90.69 0.00e+00 1258.00
IUUC-Cpo-022455 Cavia porcellus 90.46 0.00e+00 1289.00
IUUC-Csa-023660 Chlorocebus sabaeus 90.73 0.00e+00 1331.00
IUUC-Cin-025595 Ciona intestinalis 28.43 2.00e-47 184.00
IUUC-Dre-028389 Danio rerio 53.10 0.00e+00 821.00
IUUC-Dno-028907 Dasypus novemcinctus 86.04 0.00e+00 1153.00
IUUC-Dor-030300 Dipodomys ordii 95.29 2.00e-167 583.00
IUUC-Dme-031580 Drosophila melanogaster 28.77 2.00e-39 157.00
IUUC-Ete-032641 Echinops telfairi 93.84 2.00e-129 456.00
IUUC-Eca-033297 Equus caballus 90.69 0.00e+00 1279.00
IUUC-Eeu-035356 Erinaceus europaeus 83.93 0.00e+00 913.00
IUUC-Fca-036302 Felis catus 89.89 0.00e+00 1205.00
IUUC-Fal-036729 Ficedula albicollis 64.25 0.00e+00 1056.00
IUUC-Gga-040285 Gallus gallus 62.68 0.00e+00 999.00
IUUC-Ggo-045534 Gorilla gorilla 90.57 0.00e+00 1302.00
IUUC-Hsa-046672 Homo sapiens 90.69 0.00e+00 1308.00
IUUC-Itr-048045 Ictidomys tridecemlineatus 92.30 0.00e+00 1312.00
IUUC-Lch-049837 Latimeria chalumnae 59.87 0.00e+00 914.00
IUUC-Loc-052010 Lepisosteus oculatus 54.39 0.00e+00 833.00
IUUC-Laf-053978 Loxodonta africana 89.32 0.00e+00 1207.00
IUUC-Mcc-055551 Macaca mulatta 90.57 0.00e+00 1301.00
IUUC-Meu-056006 Macropus eugenii 63.86 0.00e+00 848.00
IUUC-Mga-060136 Meleagris gallopavo 40.31 2.00e-147 516.00
IUUC-Mmr-061269 Microcebus murinus 89.21 0.00e+00 1326.00
IUUC-Mpu-066694 Mustela putorius furo 89.02 0.00e+00 1208.00
IUUC-Mlu-067377 Myotis lucifugus 88.05 0.00e+00 1231.00
IUUC-Nle-069243 Nomascus leucogenys 88.55 0.00e+00 692.00
IUUC-Opr-070611 Ochotona princeps 84.04 0.00e+00 1156.00
IUUC-Ont-071724 Oreochromis niloticus 51.18 0.00e+00 755.00
IUUC-Oan-073477 Ornithorhynchus anatinus 51.42 1.00e-45 174.00
IUUC-Ocu-074436 Oryctolagus cuniculus 79.34 0.00e+00 1092.00
IUUC-Ola-086487 Oryzias latipes 47.95 0.00e+00 694.00
IUUC-Oga-088966 Otolemur garnettii 91.38 0.00e+00 1355.00
IUUC-Oar-089394 Ovis aries 77.05 4.00e-128 452.00
IUUC-Ptr-090896 Pan troglodytes 90.92 0.00e+00 1340.00
IUUC-Pan-092021 Papio anubis 90.73 0.00e+00 1307.00
IUUC-Pfo-096333 Poecilia formosa 48.46 4.00e-31 130.00
IUUC-Pab-098732 Pongo abelii 86.55 0.00e+00 1205.00
IUUC-Pca-100841 Procavia capensis 89.04 6.00e-177 614.00
IUUC-Pva-102291 Pteropus vampyrus 83.13 0.00e+00 849.00
IUUC-Rno-105602 Rattus norvegicus 97.13 0.00e+00 1417.00
IUUC-Sha-106605 Sarcophilus harrisii 63.57 1.00e-89 324.00
IUUC-Spo-108375 Schizosaccharomyces pombe 41.82 1.00e-07 53.10
IUUC-Ssc-116113 Sus scrofa 87.40 0.00e+00 1185.00
IUUC-Tgu-117420 Taeniopygia guttata 38.44 1.00e-140 493.00
IUUC-Tru-118044 Takifugu rubripes 48.20 5.00e-32 132.00
IUUC-Ttr-128533 Tursiops truncatus 87.82 0.00e+00 1194.00
IUUC-Xtr-132220 Xenopus tropicalis 30.49 4.00e-79 289.00
Created Date 25-Jun-2017

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