iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118368

UUCD1 version

UUC-TaR-00304

Ensembl Protein ID

ENSTRUP00000015495.1

UniProt Accession

H2SSV8; H2SSV8_TAKRU

Protein Name

Uncharacterized protein

Gene Name

ube3a; LOC101068793

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000006347.1	ENSTRUT00000015564.1	ENSTRUP00000015495.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.30e-106	357.2	537	863

Active Site

Position(s)	Description	Evidence
832	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e++  ++++G++lg+a++++ +ld+
   Q: 537  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDERTKLFWF-NPSSF----ENEGQYTLIGIVLGLAIYNNCILDV 620
           689*******************************************99888877.88888....6799********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slke++e+ e ++ee ++ +tf++s++  +g+   ++L ++G++ipVtneN++e+v +++
   Q: 621  HFPMVVYRKLMGKKGTFRDLADANPVLYQSLKELLEY-EGSVEE-DMMITFQISQTDlFGNPLMYDLRENGDKIPVTNENRKEFVAQYA 707
           *************************************.556665.59999996554449****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y +++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+ +l+++t+y+ggy++ds+ i+ Fwe+l++f +e+++ fLq
   Q: 708  DYMVNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRKLDFLALEETTEYDGGYNRDSRIIKEFWETLHSFGEEQKRLFLQ 796
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeYsske+l+e+Ll Ai+++kgF++
   Q: 797  FTTGTDRAPVGGLGKLK---MIIAKNGPDtDRLPTSHTCFNVLLLPEYSSKEKLRERLLKAITYAKGFGM 863
           *****************...8888866666**************************************97 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

EPEIENPEAS RMKRAAAKHL IERYYHQLTE GCGNELCSNS WCASSVGFNR MDNNAAAVKA 60
LELYKGNAKL CDPHPSKKGT ASAYLESSTH SNSACSNRKL KQDFHSVRDN FKDINYLTED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCCTGAAA TAGAAAACCC AGAAGCAAGC CGAATGTAAG TAAAACCACA TTTTATGTCT 60
CCTCGGTCAT ATAGATCAAT ATTAACTGAT TACTCTTGAG ATGTTCTCTT TTTTTTTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	86.30	0.00e+00	1433.00
IUUC-Apl-003742	Anas platyrhynchos	86.44	0.00e+00	1460.00
IUUC-Aca-004873	Anolis carolinensis	85.47	0.00e+00	1459.00
IUUC-Acl-008288	Aspergillus clavatus	36.59	2.00e-77	284.00
IUUC-Afl-008402	Aspergillus flavus	31.80	1.00e-72	268.00
IUUC-Afu-008762	Aspergillus fumigatus	36.81	3.00e-78	286.00
IUUC-Ani-009176	Aspergillus nidulans	32.49	2.00e-78	288.00
IUUC-Ang-009791	Aspergillus niger	36.50	4.00e-75	276.00
IUUC-Aor-009921	Aspergillus oryzae	31.96	2.00e-73	270.00
IUUC-Ate-010295	Aspergillus terreus	36.95	1.00e-79	291.00
IUUC-Ame-011166	Astyanax mexicanus	87.30	0.00e+00	1462.00
IUUC-Bgr-011981	Blumeria graminis	38.86	2.00e-81	297.00
IUUC-Bta-013286	Bos taurus	85.55	0.00e+00	1419.00
IUUC-Bci-013697	Botrytis cinerea	37.12	2.00e-69	258.00
IUUC-Cja-019707	Callithrix jacchus	85.78	0.00e+00	1441.00
IUUC-Cfa-020154	Canis familiaris	85.33	0.00e+00	1439.00
IUUC-Cpo-021292	Cavia porcellus	85.68	0.00e+00	1414.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	2.00e-81	295.00
IUUC-Csa-023378	Chlorocebus sabaeus	85.90	0.00e+00	1440.00
IUUC-Cho-025059	Choloepus hoffmanni	82.92	0.00e+00	1356.00
IUUC-Cin-025643	Ciona intestinalis	43.69	0.00e+00	687.00
IUUC-Csv-026282	Ciona savignyi	44.92	0.00e+00	654.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	37.69	6.00e-79	289.00
IUUC-Dre-027901	Danio rerio	86.35	0.00e+00	1443.00
IUUC-Dno-029320	Dasypus novemcinctus	85.80	0.00e+00	1444.00
IUUC-Dor-030756	Dipodomys ordii	91.37	0.00e+00	632.00
IUUC-Dse-031239	Dothistroma septosporum	35.14	2.00e-71	264.00
IUUC-Dme-032035	Drosophila melanogaster	40.46	9.00e-170	590.00
IUUC-Ete-032902	Echinops telfairi	36.25	8.00e-85	308.00
IUUC-Eca-033843	Equus caballus	86.18	0.00e+00	1411.00
IUUC-Eeu-035109	Erinaceus europaeus	85.09	0.00e+00	1399.00
IUUC-Fca-036344	Felis catus	85.35	0.00e+00	1443.00
IUUC-Fal-036747	Ficedula albicollis	86.44	0.00e+00	1461.00
IUUC-Fox-037941	Fusarium oxysporum	38.45	1.00e-86	315.00
IUUC-Fso-038388	Fusarium solani	41.46	8.00e-88	318.00
IUUC-Ggr-040110	Gaeumannomyces graminis	38.30	2.00e-77	284.00
IUUC-Gga-040399	Gallus gallus	86.44	0.00e+00	1461.00
IUUC-Gac-041933	Gasterosteus aculeatus	93.77	0.00e+00	1525.00
IUUC-Ggo-044804	Gorilla gorilla	86.01	0.00e+00	1440.00
IUUC-Hsa-045727	Homo sapiens	86.01	0.00e+00	1440.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	82.28	0.00e+00	1335.00
IUUC-Lch-050197	Latimeria chalumnae	85.47	0.00e+00	1451.00
IUUC-Loc-052743	Lepisosteus oculatus	87.93	0.00e+00	1500.00
IUUC-Lma-053245	Leptosphaeria maculans	35.11	1.00e-56	215.00
IUUC-Laf-053615	Loxodonta africana	85.45	0.00e+00	1428.00
IUUC-Mcc-054934	Macaca mulatta	85.90	0.00e+00	1438.00
IUUC-Meu-056061	Macropus eugenii	82.77	0.00e+00	1315.00
IUUC-Mor-057045	Magnaporthe oryzae	36.58	1.00e-79	291.00
IUUC-Mla-059187	Melampsora laricipopulina	36.88	7.00e-67	248.00
IUUC-Mga-059271	Meleagris gallopavo	86.71	0.00e+00	1444.00
IUUC-Mmr-061288	Microcebus murinus	86.36	0.00e+00	1449.00
IUUC-Mdo-062975	Monodelphis domestica	86.75	0.00e+00	1463.00
IUUC-Mmu-063674	Mus musculus	84.95	0.00e+00	1401.00
IUUC-Mpu-066568	Mustela putorius furo	86.03	0.00e+00	1450.00
IUUC-Mlu-067522	Myotis lucifugus	80.94	0.00e+00	1365.00
IUUC-Nfi-068439	Neosartorya fischeri	36.59	8.00e-78	285.00
IUUC-Ncr-068903	Neurospora crassa	39.01	4.00e-74	273.00
IUUC-Nle-069505	Nomascus leucogenys	86.01	0.00e+00	1440.00
IUUC-Opr-070570	Ochotona princeps	78.67	0.00e+00	1298.00
IUUC-Ont-071527	Oreochromis niloticus	94.76	0.00e+00	1601.00
IUUC-Oan-073446	Ornithorhynchus anatinus	84.02	0.00e+00	941.00
IUUC-Ocu-074922	Oryctolagus cuniculus	83.93	0.00e+00	1433.00
IUUC-Ola-086996	Oryzias latipes	92.98	0.00e+00	1571.00
IUUC-Oga-088261	Otolemur garnettii	86.52	0.00e+00	1428.00
IUUC-Oar-090024	Ovis aries	85.55	0.00e+00	1419.00
IUUC-Ptr-090455	Pan troglodytes	86.01	0.00e+00	1440.00
IUUC-Pan-092509	Papio anubis	83.88	0.00e+00	1279.00
IUUC-Psi-092974	Pelodiscus sinensis	86.31	0.00e+00	1436.00
IUUC-Pma-094643	Petromyzon marinus	70.66	0.00e+00	1239.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.06	2.00e-57	218.00
IUUC-Ppa-095354	Physcomitrella patens	46.38	8.00e-109	388.00
IUUC-Pfo-096905	Poecilia formosa	93.07	0.00e+00	1578.00
IUUC-Pab-097840	Pongo abelii	83.72	0.00e+00	1384.00
IUUC-Pca-100869	Procavia capensis	85.26	0.00e+00	1418.00
IUUC-Pva-103040	Pteropus vampyrus	90.18	0.00e+00	629.00
IUUC-Pgr-103315	Puccinia graminis	36.80	2.00e-74	274.00
IUUC-Rno-105453	Rattus norvegicus	84.61	0.00e+00	1402.00
IUUC-Sce-106306	Saccharomyces cerevisiae	36.36	2.00e-65	244.00
IUUC-Sha-107651	Sarcophilus harrisii	86.75	0.00e+00	1464.00
IUUC-Spo-108271	Schizosaccharomyces pombe	35.58	2.00e-69	257.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	36.66	2.00e-76	281.00
IUUC-Smo-108858	Selaginella moellendorffii	48.23	5.00e-112	398.00
IUUC-Sar-113293	Sorex araneus	86.77	0.00e+00	1441.00
IUUC-Ssc-115979	Sus scrofa	85.93	0.00e+00	1431.00
IUUC-Tgu-116901	Taeniopygia guttata	86.44	0.00e+00	1460.00
IUUC-Tsy-119516	Tarsius syrichta	82.30	0.00e+00	1316.00
IUUC-Tni-120143	Tetraodon nigroviridis	97.80	0.00e+00	1645.00
IUUC-Tre-122108	Trichoderma reesei	39.76	9.00e-77	282.00
IUUC-Tvi-122644	Trichoderma virens	39.57	2.00e-77	284.00
IUUC-Tme-127004	Tuber melanosporum	33.33	2.00e-81	298.00
IUUC-Tbe-127484	Tupaia belangeri	80.47	0.00e+00	959.00
IUUC-Ttr-129078	Tursiops truncatus	85.83	0.00e+00	1419.00
IUUC-Vda-129969	Verticillium dahliae	38.19	6.00e-83	302.00
IUUC-Vpa-130312	Vicugna pacos	78.11	0.00e+00	1201.00
IUUC-Xtr-132881	Xenopus tropicalis	86.27	0.00e+00	1452.00
IUUC-Xma-133122	Xiphophorus maculatus	92.73	0.00e+00	1569.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence