iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115527

Ensembl Protein ID

ENSSSCP00000030240.1

UniProt Accession

A5GFW5; A5GFW4; CASS4_PIG

Genbank Protein ID

CAN13138.1; CAN13139.1

Protein Name

Cas scaffolding protein family member 4

Genbank Nucleotide ID

CR956640; CR956640

Gene Name

CASS4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000007495.3	ENSSSCT00000036338.1	ENSSSCP00000030240.1
ENSSSCG00000007495.3	ENSSSCT00000008204.2	ENSSSCP00000007986.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-10	40.7	16	66

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPen 57
            ++lyd  +  +deL + +Gd+++++ ++  ++egW+ +   l+g++Gl P+n
   Q: 16   ARALYDNHPDCSDELAFCRGDILTILeQDVPESEGWWTC--LLHGRQGLAPAN 66
           579***********************5556799******..9**********9 PP

Organism

Sus scrofa

Functional Description
(View)

Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity).

Protein Sequence
(Fasta)

MKGAGGPDGA PKALLARALY DNHPDCSDEL AFCRGDILTI LEQDVPESEG WWTCLLHGRQ 60
GLAPANRLQI LEEAPADGPC PPFFGGLEEA PGRSQENYEV PSPPTPGPVY EQMKSWVEGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTCTAGT CCTTTCCAGA AAGTTCGCCA GCTGGGAGAA TCATTCTGAC AGTTTCCTGT 60
GCTGTCAGAT AGCTCCATAG AACTCCGTTT CTGAGAACCA GCCAGAGGCA TGCAGTGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR021901--CAS_DUF3513
IPR014928--Serine_rich
IPR001452--SH3_domain
IPR015224--Talin_cent

PROSITE

PS50002--SH3

Pfam

PF12026--DUF3513
PF08824--Serine_rich
PF14604--SH3_9

SMART

SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005925--C:focal adhesion
GO:0007155--P:cell adhesion

KEGG

ssc:100126293

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010839	Astyanax mexicanus	51.28	3.00e-30	126.00
IUUC-Bta-013513	Bos taurus	73.85	4.00e-89	322.00
IUUC-Cja-018847	Callithrix jacchus	72.95	5.00e-80	292.00
IUUC-Dno-029953	Dasypus novemcinctus	65.33	1.00e-63	238.00
IUUC-Gac-041754	Gasterosteus aculeatus	54.31	8.00e-30	125.00
IUUC-Hsa-045661	Homo sapiens	75.64	3.00e-146	510.00
IUUC-Itr-049018	Ictidomys tridecemlineatus	69.61	5.00e-74	272.00
IUUC-Loc-052714	Lepisosteus oculatus	54.55	3.00e-33	136.00
IUUC-Mcc-054708	Macaca mulatta	75.07	3.00e-141	494.00
IUUC-Meu-056005	Macropus eugenii	70.54	2.00e-49	190.00
IUUC-Mmr-061129	Microcebus murinus	73.18	6.00e-90	324.00
IUUC-Mdo-062756	Monodelphis domestica	69.29	5.00e-48	186.00
IUUC-Mmu-063574	Mus musculus	58.20	1.00e-72	268.00
IUUC-Oan-073556	Ornithorhynchus anatinus	53.06	9.00e-51	194.00
IUUC-Ocu-074645	Oryctolagus cuniculus	71.49	3.00e-82	299.00
IUUC-Pfo-097206	Poecilia formosa	58.62	4.00e-34	139.00
IUUC-Rno-105677	Rattus norvegicus	64.55	1.00e-78	287.00
IUUC-Tgu-116510	Taeniopygia guttata	57.94	3.00e-37	150.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence