iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093297

Ensembl Protein ID

ENSPSIP00000019543.1

UniProt Accession

K7GGY2; K7GGY2_PELSI

Genbank Protein ID

ENSPSIP00000019543

Protein Name

Presenilin

Genbank Nucleotide ID

AGCU01051953

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000017347.1	ENSPSIT00000019634.1	ENSPSIP00000019543.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.30e-07	31.6	285	323

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ ++a++++  
   Q: 285  VETAQERNEPIFPALIYSSAMVWTIGMAKPDPASIGCSQ 323
           89**************************99999999866 PP

Organism

Pelodiscus sinensis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MMITFMNSSD SEEEACNERT SLMSAESPPV SSYQDGLQAP EASETPAHRK SHTGGSRSPS 60
DDVDGGNSES GLPVRDIPLD NEEEELTLKY GAKHVIMLFV PVTLCMIVVV ATIKSVRFYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACACGGGTT ATGGCCGACA GCCGACTGGG CCAATCAGAA ACCCCGCTAA TTCTAGGCCG 60
GCGTTCGGAA ATGAAACGCG GCGGAGCCAA TGGGAGTGGA GCACAGCGGG GCCGGGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	67.15	2.00e-109	389.00
IUUC-Apl-003959	Anas platyrhynchos	83.33	3.00e-165	574.00
IUUC-Aca-005160	Anolis carolinensis	80.69	6.00e-149	520.00
IUUC-Bgr-012160	Blumeria graminis	28.41	2.70e+00	28.50
IUUC-Bta-013097	Bos taurus	77.62	8.00e-135	473.00
IUUC-Cja-018824	Callithrix jacchus	75.29	8.00e-129	453.00
IUUC-Cfa-020253	Canis familiaris	75.86	8.00e-134	469.00
IUUC-Cpo-021401	Cavia porcellus	75.79	5.00e-133	467.00
IUUC-Csa-023369	Chlorocebus sabaeus	76.81	1.00e-134	472.00
IUUC-Dor-031127	Dipodomys ordii	78.22	3.00e-126	444.00
IUUC-Eeu-034846	Erinaceus europaeus	63.74	2.00e-108	385.00
IUUC-Fal-037457	Ficedula albicollis	85.15	4.00e-162	563.00
IUUC-Gga-040706	Gallus gallus	83.82	9.00e-157	546.00
IUUC-Ggo-045338	Gorilla gorilla	77.10	1.00e-134	473.00
IUUC-Hsa-046455	Homo sapiens	77.10	8.00e-135	473.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	77.19	6.00e-134	470.00
IUUC-Mcc-054755	Macaca mulatta	77.10	2.00e-134	471.00
IUUC-Mmr-060890	Microcebus murinus	76.23	5.00e-133	467.00
IUUC-Mmu-063823	Mus musculus	76.32	2.00e-133	468.00
IUUC-Mpu-066181	Mustela putorius furo	76.32	3.00e-134	471.00
IUUC-Nle-069596	Nomascus leucogenys	77.10	1.00e-134	472.00
IUUC-Oan-073378	Ornithorhynchus anatinus	72.09	7.00e-132	463.00
IUUC-Ocu-074652	Oryctolagus cuniculus	75.73	1.00e-131	462.00
IUUC-Ola-086707	Oryzias latipes	70.19	5.00e-105	373.00
IUUC-Oga-088560	Otolemur garnettii	75.65	6.00e-130	457.00
IUUC-Oar-089200	Ovis aries	76.45	2.00e-132	465.00
IUUC-Ptr-090569	Pan troglodytes	76.81	8.00e-134	469.00
IUUC-Pan-091742	Papio anubis	77.10	2.00e-134	472.00
IUUC-Ppa-095431	Physcomitrella patens	31.85	8.00e-25	107.00
IUUC-Pab-098531	Pongo abelii	76.81	1.00e-134	472.00
IUUC-Pca-101120	Procavia capensis	73.98	6.00e-126	443.00
IUUC-Ssc-115380	Sus scrofa	77.19	6.00e-135	473.00
IUUC-Tgu-117280	Taeniopygia guttata	85.41	2.00e-162	565.00
IUUC-Tbe-127632	Tupaia belangeri	76.90	3.00e-132	464.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence