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Tag Content
iUUCD ID IUUC-Pab-098044
Ensembl Protein ID ENSPPYP00000005320.2
UniProt Accession Q5R9I9; NACA_PONAB
Genbank Protein ID CAH91571.1
Protein Name Nascent polypeptide-associated complex subunit alpha; Alpha-NAC
Genbank Nucleotide ID CR859398
Gene Name NACA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000004670.2 ENSPPYT00000005529.2 ENSPPYP00000005320.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 38.51 4.00e-19 89.40 IUUC-Sce-106371
UBD/Alpha-Helix/UBA 47.65 2.00e-24 106.00 IUUC-Spo-108121
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Pongo abelii
Functional Description
(View)

Functional Description


     Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters (By similarity).
 Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters (By similarity).
Protein Sequence
(Fasta)
MPGEATETVP ATEQELPQPQ AETGSGTESD SDESVPELEE QDSTQATTQQ AQLAAAAEID 60
EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK NILFVITKPD VYKSPASDTY 120
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Protein Fasta Sequence


>IUUC-Pab-098044|UBD,UBA|Pongo abelii
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Nucleotide Sequence
(Fasta)
AAATGCCCGG CGAAGCCACA GAAACCGTCC CTGCTACAGA GCAGGAGTTG CCGCAGCCCC 60
AGGCTGAGAC AGGTAGGTTC CGCTACCCCC CTTGCCATTA ATTAAAATTG ACCCTAACGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-098044|UBD,UBA|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0804--Transcription
KW-0813--Transport
Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom
PROSITE

PS51151--NAC_AB
Pfam

PF01849--NAC
SMART

SM01407--NAC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0015031--P:protein transport
GO:0006351--P:transcription, DNA-templated
KEGG pon:100172857
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001167 Aegilops tauschii 62.50 1.00e-35 142.00
IUUC-Aml-001719 Ailuropoda melanoleuca 100.00 7.00e-86 313.00
IUUC-Atr-002586 Amborella trichopoda 50.00 6.00e-28 117.00
IUUC-Apl-003190 Anas platyrhynchos 72.61 5.00e-53 199.00
IUUC-Aca-005265 Anolis carolinensis 97.40 3.00e-84 303.00
IUUC-Aly-006397 Arabidopsis lyrata 62.50 1.00e-37 149.00
IUUC-Ath-007378 Arabidopsis thaliana 59.42 2.00e-30 125.00
IUUC-Ago-007936 Ashbya gossypii 39.63 2.00e-22 98.20
IUUC-Acl-008036 Aspergillus clavatus 70.49 3.00e-23 101.00
IUUC-Afl-008462 Aspergillus flavus 51.57 2.00e-35 141.00
IUUC-Afu-008832 Aspergillus fumigatus 70.49 2.00e-23 101.00
IUUC-Ani-009246 Aspergillus nidulans 70.31 9.00e-25 106.00
IUUC-Ang-009808 Aspergillus niger 50.63 2.00e-33 135.00
IUUC-Aor-009972 Aspergillus oryzae 51.57 2.00e-35 141.00
IUUC-Ame-011674 Astyanax mexicanus 95.81 3.00e-86 310.00
IUUC-Bgr-012162 Blumeria graminis 51.52 2.00e-36 145.00
IUUC-Bta-012508 Bos taurus 99.53 4.00e-96 343.00
IUUC-Bci-013643 Botrytis cinerea 50.90 1.00e-33 135.00
IUUC-Bdi-014874 Brachypodium distachyon 59.56 7.00e-34 136.00
IUUC-Bol-015681 Brassica oleracea 58.82 3.00e-36 144.00
IUUC-Bra-017540 Brassica rapa 59.42 3.00e-35 140.00
IUUC-Cel-018111 Caenorhabditis elegans 66.01 1.00e-47 182.00
IUUC-Cja-019846 Callithrix jacchus 62.25 3.00e-59 224.00
IUUC-Cfa-020429 Canis familiaris 95.17 6.00e-84 303.00
IUUC-Cpo-022542 Cavia porcellus 99.53 4.00e-87 313.00
IUUC-Cre-022679 Chlamydomonas reinhardtii 66.00 3.00e-48 184.00
IUUC-Csa-023260 Chlorocebus sabaeus 65.33 1.00e-59 225.00
IUUC-Cho-024869 Choloepus hoffmanni 75.25 4.00e-51 193.00
IUUC-Cin-025166 Ciona intestinalis 72.00 5.00e-51 193.00
IUUC-Csv-026284 Ciona savignyi 70.59 2.00e-43 167.00
IUUC-Cgl-026520 Colletotrichum gloeosporioides 56.05 7.00e-33 133.00
IUUC-Cne-026920 Cryptococcus neoformans 61.29 4.00e-21 94.40
IUUC-Cme-027301 Cyanidioschyzon merolae 50.00 4.00e-29 121.00
IUUC-Dre-028709 Danio rerio 95.88 5.00e-82 299.00
IUUC-Dno-029786 Dasypus novemcinctus 100.00 8.00e-85 309.00
IUUC-Dor-030962 Dipodomys ordii 94.42 3.00e-92 330.00
IUUC-Dme-032061 Drosophila melanogaster 70.78 3.00e-37 147.00
IUUC-Ete-032965 Echinops telfairi 93.20 1.00e-87 315.00
IUUC-Eca-034049 Equus caballus 99.53 8.00e-96 342.00
IUUC-Eeu-034673 Erinaceus europaeus 100.00 2.00e-96 344.00
IUUC-Fca-036369 Felis catus 100.00 1.00e-85 311.00
IUUC-Fal-037006 Ficedula albicollis 98.45 1.00e-81 295.00
IUUC-Fox-037704 Fusarium oxysporum 53.09 3.00e-33 134.00
IUUC-Fso-038247 Fusarium solani 51.22 7.00e-33 133.00
IUUC-Gmo-039002 Gadus morhua 69.23 1.00e-50 192.00
IUUC-Ggr-039888 Gaeumannomyces graminis 51.88 1.00e-33 135.00
IUUC-Gga-040237 Gallus gallus 99.53 4.00e-96 343.00
IUUC-Gac-041800 Gasterosteus aculeatus 96.37 1.00e-70 260.00
IUUC-Gma-043275 Glycine max 63.76 1.00e-43 169.00
IUUC-Ggo-045163 Gorilla gorilla 62.67 4.00e-63 234.00
IUUC-Hsa-045795 Homo sapiens 100.00 6.00e-85 310.00
IUUC-Hvu-047376 Hordeum vulgare 62.50 5.00e-36 144.00
IUUC-Itr-048152 Ictidomys tridecemlineatus 100.00 2.00e-96 344.00
IUUC-Kpa-049166 Komagataella pastoris 38.79 1.00e-23 102.00
IUUC-Lch-050076 Latimeria chalumnae 98.14 1.00e-94 338.00
IUUC-Lpe-051258 Leersia perrieri 62.50 1.00e-37 149.00
IUUC-Loc-052292 Lepisosteus oculatus 96.68 4.00e-76 277.00
IUUC-Lma-053293 Leptosphaeria maculans 69.12 2.00e-25 108.00
IUUC-Laf-054393 Loxodonta africana 60.35 5.00e-61 227.00
IUUC-Mcc-054632 Macaca mulatta 100.00 1.00e-84 308.00
IUUC-Meu-056242 Macropus eugenii 91.63 3.00e-83 300.00
IUUC-Mor-057099 Magnaporthe oryzae 54.19 2.00e-30 125.00
IUUC-Mpo-057543 Magnaporthe poae 44.22 1.00e-24 105.00
IUUC-Mtr-058769 Medicago truncatula 57.97 9.00e-29 119.00
IUUC-Mla-059166 Melampsora laricipopulina 41.67 3.00e-24 104.00
IUUC-Mga-059406 Meleagris gallopavo 92.06 2.00e-83 301.00
IUUC-Mvi-060390 Microbotryum violaceum 39.38 2.00e-23 101.00
IUUC-Mmr-061569 Microcebus murinus 97.46 8.00e-82 296.00
IUUC-Mdo-062077 Monodelphis domestica 100.00 3.00e-77 283.00
IUUC-Mmu-063984 Mus musculus 98.96 2.00e-85 311.00
IUUC-Mac-065175 Musa acuminata 62.50 3.00e-38 151.00
IUUC-Mpu-065793 Mustela putorius furo 95.31 9.00e-78 286.00
IUUC-Mlu-068234 Myotis lucifugus 100.00 2.00e-96 344.00
IUUC-Nfi-068541 Neosartorya fischeri 70.49 2.00e-23 101.00
IUUC-Ncr-068830 Neurospora crassa 56.21 3.00e-32 131.00
IUUC-Nle-069126 Nomascus leucogenys 99.53 8.00e-95 339.00
IUUC-Opr-070742 Ochotona princeps 86.51 3.00e-82 297.00
IUUC-Ont-071828 Oreochromis niloticus 94.85 7.00e-73 266.00
IUUC-Oan-073462 Ornithorhynchus anatinus 99.47 2.00e-81 298.00
IUUC-Ocu-074890 Oryctolagus cuniculus 63.32 1.00e-59 226.00
IUUC-Oba-075995 Oryza barthii 59.72 2.00e-39 155.00
IUUC-Obr-076073 Oryza brachyantha 58.33 2.00e-39 155.00
IUUC-Ogl-077445 Oryza glaberrima 59.72 2.00e-39 155.00
IUUC-Ogu-078606 Oryza glumaepatula 59.72 2.00e-39 155.00
IUUC-Oin-079287 Oryza indica 59.72 2.00e-39 155.00
IUUC-Olo-080686 Oryza longistaminata 55.48 1.00e-34 139.00
IUUC-Ome-081567 Oryza meridionalis 63.24 1.00e-38 151.00
IUUC-Oni-082873 Oryza nivara 59.72 2.00e-39 155.00
IUUC-Opu-083488 Oryza punctata 58.70 1.00e-36 145.00
IUUC-Oru-084592 Oryza rufipogon 59.72 2.00e-39 155.00
IUUC-Osa-086102 Oryza sativa 59.72 2.00e-39 155.00
IUUC-Ola-087531 Oryzias latipes 95.35 3.00e-81 293.00
IUUC-Olu-087895 Ostreococcus lucimarinus 53.28 3.00e-31 126.00
IUUC-Oga-088239 Otolemur garnettii 100.00 2.00e-96 344.00
IUUC-Oar-089723 Ovis aries 100.00 3.00e-86 314.00
IUUC-Ptr-090481 Pan troglodytes 67.68 4.00e-58 220.00
IUUC-Pan-092223 Papio anubis 100.00 3.00e-83 303.00
IUUC-Psi-093588 Pelodiscus sinensis 99.07 2.00e-96 344.00
IUUC-Pma-094702 Petromyzon marinus 77.98 2.00e-62 231.00
IUUC-Pno-094927 Phaeosphaeria nodorum 69.12 2.00e-25 108.00
IUUC-Ppa-095389 Physcomitrella patens 66.67 5.00e-40 157.00
IUUC-Pfo-096744 Poecilia formosa 94.42 3.00e-76 277.00
IUUC-Pop-099384 Populus trichocarpa 65.10 2.00e-44 171.00
IUUC-Pca-100355 Procavia capensis 67.84 9.00e-59 222.00
IUUC-Ppe-101786 Prunus persica 62.50 2.00e-39 154.00
IUUC-Pva-102494 Pteropus vampyrus 98.14 1.00e-94 338.00
IUUC-Pgr-103303 Puccinia graminis 40.88 1.00e-25 109.00
IUUC-Ptt-103748 Puccinia triticina 33.58 6.00e-12 63.90
IUUC-Pte-104368 Pyrenophora teres 49.70 6.00e-35 140.00
IUUC-Pyt-104542 Pyrenophora triticirepentis 69.12 2.00e-25 108.00
IUUC-Rno-105387 Rattus norvegicus 98.96 5.00e-85 310.00
IUUC-Sce-106371 Saccharomyces cerevisiae 38.89 3.00e-20 90.90
IUUC-Sha-107189 Sarcophilus harrisii 100.00 2.00e-96 344.00
IUUC-Sja-107942 Schizosaccharomyces japonicus 45.40 2.00e-24 104.00
IUUC-Spo-108121 Schizosaccharomyces pombe 47.65 3.00e-27 114.00
IUUC-Ssl-108595 Sclerotinia sclerotiorum 71.88 5.00e-24 103.00
IUUC-Smo-108783 Selaginella moellendorffii 66.18 9.00e-40 156.00
IUUC-Sit-109728 Setaria italica 63.97 3.00e-39 154.00
IUUC-Sly-110957 Solanum lycopersicum 63.24 3.00e-35 141.00
IUUC-Stu-112873 Solanum tuberosum 63.24 2.00e-35 141.00
IUUC-Sar-113668 Sorex araneus 100.00 2.00e-29 122.00
IUUC-Sbi-114328 Sorghum bicolor 64.71 7.00e-40 156.00
IUUC-Sre-115220 Sporisorium reilianum 44.00 1.00e-23 102.00
IUUC-Ssc-116119 Sus scrofa 100.00 2.00e-96 344.00
IUUC-Tgu-116528 Taeniopygia guttata 99.47 3.00e-79 287.00
IUUC-Tru-117538 Takifugu rubripes 90.09 7.00e-76 276.00
IUUC-Tsy-118855 Tarsius syrichta 100.00 6.00e-17 80.10
IUUC-Tni-120134 Tetraodon nigroviridis 95.35 2.00e-79 288.00
IUUC-Tca-121524 Theobroma cacao 62.50 2.00e-38 152.00
IUUC-Tre-121915 Trichoderma reesei 67.69 2.00e-20 92.40
IUUC-Tvi-122411 Trichoderma virens 68.85 1.00e-18 86.30
IUUC-Tae-124851 Triticum aestivum 59.72 5.00e-36 144.00
IUUC-Tur-126821 Triticum urartu 62.50 5.00e-36 143.00
IUUC-Tme-126875 Tuber melanosporum 69.70 8.00e-25 106.00
IUUC-Tbe-127759 Tupaia belangeri 89.77 6.00e-74 269.00
IUUC-Ttr-129124 Tursiops truncatus 67.32 5.00e-60 226.00
IUUC-Uma-129551 Ustilago maydis 45.03 3.00e-26 110.00
IUUC-Vda-129992 Verticillium dahliae 54.09 4.00e-33 134.00
IUUC-Vpa-130096 Vicugna pacos 97.67 3.00e-84 303.00
IUUC-Vvi-130940 Vitis vinifera 57.97 8.00e-31 126.00
IUUC-Xtr-132454 Xenopus tropicalis 96.91 6.00e-79 286.00
IUUC-Xma-133842 Xiphophorus maculatus 94.33 8.00e-73 266.00
IUUC-Yli-134485 Yarrowia lipolytica 47.54 1.00e-14 72.80
IUUC-Zma-135748 Zea mays 63.97 2.00e-39 155.00
Created Date 25-Jun-2017

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