iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090853

UUCD1 version

UUC-PaT-00566

Ensembl Protein ID

ENSPTRP00000050429.3

UniProt Accession

Q1XHU0; Q1XHU1; TRI39_PANTR

Genbank Protein ID

BAE92829.1; BAE92830.1

Protein Name

E3 ubiquitin-protein ligase TRIM39; RING-type E3 ubiquitin transferase TRIM39; Tripartite motif-containing protein 39

Genbank Nucleotide ID

AB210207; AB210208

Gene Name

TRIM39

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000017923.6	ENSPTRT00000057537.3	ENSPTRP00000050429.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.90e-08	34.1	29	70
E3 activity/RING/U-box	7.30e-08	32.4	27	87

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle +k+ p++  CgH f++ C+ +w        + f CP+Cr
   Q: 29   CSVCLEYLKE-PVIIECGHNFCKACITRW---WEDLERDFPCPVCR 70
           ********99.999************999...666889999****8 PP

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwlasggk..tcPvtrqplteedlvPnltlrrl 64
             C++ le  ++Pv++++G+ + +++I +w ++ ++   cPv+r++ + ++l Pn  l ++
   Q: 27   ASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERdfPCPVCRKTSRYRSLRPNRQLGSM 87
           68*****************************88887799****************998666 PP

Organism

Pan troglodytes

Functional Description
(View)

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

Protein Sequence
(Fasta)

MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL 60
ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAACTCTGA CGCAGTCGCC GCGGGTCTCG GCTGCGTCAT AGCGGCGGGC ATCCCATCTT 60
CACGTCACAC CTCTTTCTCA CCTGGACACG CATCCCTTCC TACCCTGCCA GCCACGACGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

ptr:462537

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001603	Ailuropoda melanoleuca	93.44	0.00e+00	947.00
IUUC-Apl-003354	Anas platyrhynchos	40.87	1.00e-104	373.00
IUUC-Aca-005381	Anolis carolinensis	71.97	0.00e+00	695.00
IUUC-Bta-012554	Bos taurus	88.78	4.00e-155	540.00
IUUC-Cja-019323	Callithrix jacchus	93.76	0.00e+00	926.00
IUUC-Cfa-020342	Canis familiaris	93.36	0.00e+00	943.00
IUUC-Cpo-022084	Cavia porcellus	87.50	1.00e-152	532.00
IUUC-Csa-023186	Chlorocebus sabaeus	93.96	0.00e+00	947.00
IUUC-Cho-024697	Choloepus hoffmanni	89.54	0.00e+00	889.00
IUUC-Dor-031021	Dipodomys ordii	90.48	8.00e-153	533.00
IUUC-Ete-032936	Echinops telfairi	87.76	5.00e-157	546.00
IUUC-Eca-033687	Equus caballus	89.10	2.00e-155	541.00
IUUC-Eeu-034957	Erinaceus europaeus	94.63	2.00e-134	472.00
IUUC-Fca-035406	Felis catus	93.16	0.00e+00	942.00
IUUC-Fal-036705	Ficedula albicollis	43.83	3.00e-95	342.00
IUUC-Gmo-038505	Gadus morhua	33.94	1.00e-68	253.00
IUUC-Gac-041919	Gasterosteus aculeatus	35.37	3.00e-70	258.00
IUUC-Ggo-044526	Gorilla gorilla	100.00	0.00e+00	1029.00
IUUC-Hsa-045719	Homo sapiens	99.80	0.00e+00	1027.00
IUUC-Itr-048404	Ictidomys tridecemlineatus	91.88	0.00e+00	935.00
IUUC-Lch-050632	Latimeria chalumnae	38.87	2.00e-86	312.00
IUUC-Loc-052206	Lepisosteus oculatus	36.62	1.00e-83	303.00
IUUC-Laf-054295	Loxodonta africana	92.59	0.00e+00	941.00
IUUC-Mcc-055765	Macaca mulatta	98.39	0.00e+00	1002.00
IUUC-Mmr-061030	Microcebus murinus	90.50	0.00e+00	661.00
IUUC-Mdo-062936	Monodelphis domestica	84.62	0.00e+00	840.00
IUUC-Mmu-063767	Mus musculus	91.75	0.00e+00	929.00
IUUC-Mpu-066160	Mustela putorius furo	93.44	0.00e+00	947.00
IUUC-Mlu-068126	Myotis lucifugus	86.22	1.00e-150	525.00
IUUC-Nle-070041	Nomascus leucogenys	95.44	0.00e+00	891.00
IUUC-Opr-070394	Ochotona princeps	95.17	0.00e+00	959.00
IUUC-Oan-072828	Ornithorhynchus anatinus	54.69	1.00e-158	552.00
IUUC-Ocu-073980	Oryctolagus cuniculus	90.24	0.00e+00	681.00
IUUC-Ola-086686	Oryzias latipes	32.61	2.00e-65	243.00
IUUC-Oga-088422	Otolemur garnettii	88.50	0.00e+00	888.00
IUUC-Oar-089277	Ovis aries	88.33	0.00e+00	867.00
IUUC-Pan-091993	Papio anubis	93.96	0.00e+00	947.00
IUUC-Psi-092975	Pelodiscus sinensis	70.78	0.00e+00	637.00
IUUC-Pfo-096831	Poecilia formosa	32.29	2.00e-67	249.00
IUUC-Pab-097944	Pongo abelii	93.96	0.00e+00	947.00
IUUC-Pca-100795	Procavia capensis	90.19	0.00e+00	649.00
IUUC-Pva-103180	Pteropus vampyrus	95.19	0.00e+00	957.00
IUUC-Rno-105736	Rattus norvegicus	90.10	0.00e+00	918.00
IUUC-Sha-107411	Sarcophilus harrisii	50.50	1.00e-144	506.00
IUUC-Sar-113371	Sorex araneus	92.48	0.00e+00	781.00
IUUC-Ssc-116025	Sus scrofa	93.76	0.00e+00	947.00
IUUC-Tgu-116998	Taeniopygia guttata	44.66	3.00e-98	352.00
IUUC-Tru-117532	Takifugu rubripes	32.99	8.00e-71	261.00
IUUC-Tsy-119072	Tarsius syrichta	91.28	0.00e+00	671.00
IUUC-Tbe-127820	Tupaia belangeri	91.14	2.00e-146	512.00
IUUC-Ttr-128310	Tursiops truncatus	81.69	0.00e+00	810.00
IUUC-Vpa-130803	Vicugna pacos	96.18	0.00e+00	981.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence