iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132196

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Genbank Nucleotide ID

AAMC01132655

Gene Name

rnf168; RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000003128.3	ENSXETT00000006779.3	ENSXETP00000006779.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/MIU	40.71	3.00e-67	254.00	IUUC-Hsa-046424
UBD/Alpha-Helix/UMI	40.71	3.00e-67	254.00	IUUC-Hsa-046424
E3 activity/RING/RING	40.71	3.00e-67	254.00	IUUC-Hsa-046424

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MAKVQKLPLP WSECICPICQ EILLEPVTLP CKHTLCNPCF QMTVEKASLC CPFCRKRVST 60
WARQHSRTRT LVNKELWEVI QKQYPKQCQR RASGQESDDL SDELTSCPVP VLCKPGEIRQ 120

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Nucleotide Sequence
(Fasta)

AGGGTTTGAG GGGTTTGTAC GCACGGCGGG TTGCGCAGGA TTCTGGGAGA CTGATATACC 60
CCCGAAAGCT TACACTTCAA GAGCATGAAT GGCCGAACGT CCGGGGTAAG TGCTTCTACT 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001573	Ailuropoda melanoleuca	41.30	9.00e-64	237.00
IUUC-Apl-003963	Anas platyrhynchos	48.25	8.00e-51	194.00
IUUC-Aca-004420	Anolis carolinensis	59.84	2.00e-42	166.00
IUUC-Ame-011521	Astyanax mexicanus	55.19	5.00e-43	168.00
IUUC-Bta-013002	Bos taurus	40.63	2.00e-62	233.00
IUUC-Cja-019945	Callithrix jacchus	39.58	3.00e-62	232.00
IUUC-Cfa-020533	Canis familiaris	40.38	2.00e-64	239.00
IUUC-Cpo-021643	Cavia porcellus	56.11	5.00e-46	178.00
IUUC-Csa-023638	Chlorocebus sabaeus	39.68	2.00e-67	249.00
IUUC-Cho-024319	Choloepus hoffmanni	41.64	2.00e-61	229.00
IUUC-Cin-025679	Ciona intestinalis	41.67	1.00e-20	93.60
IUUC-Csv-026052	Ciona savignyi	36.30	8.00e-23	100.00
IUUC-Dre-028519	Danio rerio	37.31	1.00e-50	194.00
IUUC-Dno-029294	Dasypus novemcinctus	42.96	8.00e-69	254.00
IUUC-Ete-032714	Echinops telfairi	67.59	5.00e-40	158.00
IUUC-Eca-033343	Equus caballus	44.96	5.00e-69	254.00
IUUC-Eeu-034633	Erinaceus europaeus	67.65	7.00e-07	48.10
IUUC-Fca-036251	Felis catus	41.88	7.00e-70	258.00
IUUC-Fal-037048	Ficedula albicollis	35.67	1.00e-64	240.00
IUUC-Gmo-039400	Gadus morhua	56.41	1.00e-36	144.00
IUUC-Gga-040444	Gallus gallus	53.81	8.00e-56	211.00
IUUC-Gac-041735	Gasterosteus aculeatus	48.97	3.00e-38	151.00
IUUC-Ggo-044940	Gorilla gorilla	36.99	2.00e-14	73.60
IUUC-Hsa-046424	Homo sapiens	40.88	5.00e-65	241.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	61.58	4.00e-42	165.00
IUUC-Lch-050649	Latimeria chalumnae	60.64	9.00e-48	184.00
IUUC-Loc-051847	Lepisosteus oculatus	39.57	2.00e-52	199.00
IUUC-Laf-053938	Loxodonta africana	37.65	3.00e-65	242.00
IUUC-Mcc-055360	Macaca mulatta	40.98	5.00e-63	235.00
IUUC-Meu-056684	Macropus eugenii	56.31	4.00e-46	179.00
IUUC-Mga-059699	Meleagris gallopavo	37.08	2.00e-63	236.00
IUUC-Mmr-060779	Microcebus murinus	41.01	2.00e-70	259.00
IUUC-Mdo-062225	Monodelphis domestica	37.73	4.00e-67	248.00
IUUC-Mmu-064239	Mus musculus	44.24	3.00e-59	222.00
IUUC-Mpu-066141	Mustela putorius furo	41.49	4.00e-73	268.00
IUUC-Mlu-067945	Myotis lucifugus	55.15	4.00e-51	196.00
IUUC-Nle-069769	Nomascus leucogenys	52.20	1.00e-48	187.00
IUUC-Opr-070905	Ochotona princeps	37.23	3.00e-58	219.00
IUUC-Ont-071477	Oreochromis niloticus	51.68	2.00e-36	146.00
IUUC-Oan-073587	Ornithorhynchus anatinus	62.79	3.00e-43	166.00
IUUC-Ocu-073832	Oryctolagus cuniculus	41.86	4.00e-68	252.00
IUUC-Ola-086478	Oryzias latipes	58.06	4.00e-38	149.00
IUUC-Oga-088318	Otolemur garnettii	40.35	3.00e-58	219.00
IUUC-Oar-089647	Ovis aries	39.93	3.00e-62	233.00
IUUC-Ptr-090516	Pan troglodytes	52.20	4.00e-52	199.00
IUUC-Pan-092302	Papio anubis	40.98	1.00e-62	234.00
IUUC-Psi-093604	Pelodiscus sinensis	61.38	1.00e-47	184.00
IUUC-Pfo-096441	Poecilia formosa	54.29	2.00e-42	166.00
IUUC-Pab-097729	Pongo abelii	40.50	8.00e-63	234.00
IUUC-Pca-100552	Procavia capensis	68.54	1.00e-36	147.00
IUUC-Pva-102780	Pteropus vampyrus	41.03	7.00e-65	241.00
IUUC-Rno-105461	Rattus norvegicus	42.89	1.00e-65	243.00
IUUC-Sha-106809	Sarcophilus harrisii	37.76	8.00e-63	234.00
IUUC-Sar-113579	Sorex araneus	38.78	2.00e-61	229.00
IUUC-Tgu-117187	Taeniopygia guttata	58.95	3.00e-50	191.00
IUUC-Tru-118182	Takifugu rubripes	57.14	1.00e-35	144.00
IUUC-Tsy-119217	Tarsius syrichta	66.67	9.00e-09	54.30
IUUC-Tni-120205	Tetraodon nigroviridis	56.62	4.00e-42	164.00
IUUC-Tvi-122557	Trichoderma virens	40.43	5.00e-05	42.00
IUUC-Tbe-127622	Tupaia belangeri	39.41	2.00e-70	259.00
IUUC-Ttr-128988	Tursiops truncatus	41.36	2.00e-62	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence