iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000006076.2	ENSCJAT00000012042.2	ENSCJAP00000011413.2
ENSCJAG00000006076.2	ENSCJAT00000012134.2	ENSCJAP00000011502.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-121	407.4	3945	4279
UBD/Alpha-Helix/UBA	1.10e-07	32.7	1318	1355

Active Site

Position(s)	Description	Evidence
4247	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 3945 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4030
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4031 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4114
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4115 LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRA 4200
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s e+l+++Ll+Ai+e+ +gF+l
   Q: 4201 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGL 4279
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1318 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1355
           89**********************.7***********98 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTCTGGG ATAGGGCTGA AGCAGGGCCG CGGATCCCGC ACGCTCCTGC GGGCCCCGCG 60
GAGCCATTGC GGCCGAGGTG AGCGTCTATC CCTGGGCTGG GCGGGGGGAG CTGTGTTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	47.07	1.00e-105	379.00
IUUC-Aml-001684	Ailuropoda melanoleuca	99.25	0.00e+00	4438.00
IUUC-Atr-003044	Amborella trichopoda	53.04	2.00e-125	445.00
IUUC-Apl-003729	Anas platyrhynchos	92.44	0.00e+00	686.00
IUUC-Aca-005263	Anolis carolinensis	92.28	0.00e+00	3117.00
IUUC-Aly-006083	Arabidopsis lyrata	51.66	3.00e-125	444.00
IUUC-Ath-007472	Arabidopsis thaliana	51.66	2.00e-125	445.00
IUUC-Ago-008005	Ashbya gossypii	46.08	1.00e-128	456.00
IUUC-Acl-008254	Aspergillus clavatus	46.64	2.00e-133	472.00
IUUC-Afl-008712	Aspergillus flavus	45.57	5.00e-135	475.00
IUUC-Afu-009022	Aspergillus fumigatus	46.27	1.00e-132	469.00
IUUC-Ani-009412	Aspergillus nidulans	46.83	6.00e-135	477.00
IUUC-Ang-009771	Aspergillus niger	46.83	1.00e-133	473.00
IUUC-Aor-010186	Aspergillus oryzae	44.74	1.00e-125	444.00
IUUC-Ate-010253	Aspergillus terreus	47.23	2.00e-133	472.00
IUUC-Ame-011067	Astyanax mexicanus	81.00	0.00e+00	3662.00
IUUC-Bgr-012043	Blumeria graminis	46.53	1.00e-137	486.00
IUUC-Bta-012813	Bos taurus	99.04	0.00e+00	4462.00
IUUC-Bci-013995	Botrytis cinerea	45.88	3.00e-136	481.00
IUUC-Bdi-014884	Brachypodium distachyon	52.10	2.00e-126	448.00
IUUC-Bol-016533	Brassica oleracea	58.33	5.00e-89	320.00
IUUC-Bra-016637	Brassica rapa	44.29	5.00e-122	434.00
IUUC-Cel-018179	Caenorhabditis elegans	61.01	0.00e+00	636.00
IUUC-Cfa-020083	Canis familiaris	97.43	0.00e+00	4422.00
IUUC-Cpo-021923	Cavia porcellus	98.30	0.00e+00	4399.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	49.18	2.00e-119	422.00
IUUC-Csa-023853	Chlorocebus sabaeus	99.50	0.00e+00	4457.00
IUUC-Cho-024718	Choloepus hoffmanni	100.00	0.00e+00	814.00
IUUC-Cin-025627	Ciona intestinalis	43.12	0.00e+00	1935.00
IUUC-Csv-025824	Ciona savignyi	48.10	0.00e+00	1446.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	52.89	4.00e-136	481.00
IUUC-Cne-027095	Cryptococcus neoformans	40.83	2.00e-105	378.00
IUUC-Cme-027267	Cyanidioschyzon merolae	49.88	6.00e-115	409.00
IUUC-Dre-028525	Danio rerio	82.08	0.00e+00	3642.00
IUUC-Dno-029680	Dasypus novemcinctus	98.17	0.00e+00	4371.00
IUUC-Dor-030902	Dipodomys ordii	96.35	0.00e+00	1216.00
IUUC-Dse-031197	Dothistroma septosporum	47.22	3.00e-137	485.00
IUUC-Dme-032122	Drosophila melanogaster	67.72	0.00e+00	781.00
IUUC-Ete-032690	Echinops telfairi	83.94	0.00e+00	1130.00
IUUC-Eca-033915	Equus caballus	98.79	0.00e+00	4409.00
IUUC-Eeu-034963	Erinaceus europaeus	93.94	0.00e+00	2964.00
IUUC-Fca-035824	Felis catus	99.38	0.00e+00	4444.00
IUUC-Fox-037756	Fusarium oxysporum	53.53	2.00e-136	482.00
IUUC-Fso-038464	Fusarium solani	54.72	3.00e-136	481.00
IUUC-Gmo-039073	Gadus morhua	83.13	0.00e+00	3660.00
IUUC-Ggr-039946	Gaeumannomyces graminis	52.75	2.00e-133	472.00
IUUC-Gga-040309	Gallus gallus	98.38	0.00e+00	654.00
IUUC-Gac-042430	Gasterosteus aculeatus	83.31	0.00e+00	3735.00
IUUC-Gma-044247	Glycine max	52.10	7.00e-125	443.00
IUUC-Ggo-044785	Gorilla gorilla	99.46	0.00e+00	4411.00
IUUC-Hsa-046879	Homo sapiens	99.50	0.00e+00	4415.00
IUUC-Hvu-047697	Hordeum vulgare	45.09	5.00e-127	450.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	94.99	0.00e+00	1111.00
IUUC-Kpa-049228	Komagataella pastoris	48.50	3.00e-138	488.00
IUUC-Lch-050252	Latimeria chalumnae	88.76	0.00e+00	3367.00
IUUC-Lpe-051550	Leersia perrieri	52.10	2.00e-126	448.00
IUUC-Loc-052472	Lepisosteus oculatus	83.68	0.00e+00	3755.00
IUUC-Lma-053159	Leptosphaeria maculans	45.32	1.00e-135	479.00
IUUC-Laf-054154	Loxodonta africana	98.26	0.00e+00	4397.00
IUUC-Mcc-055085	Macaca mulatta	97.86	0.00e+00	4405.00
IUUC-Meu-056727	Macropus eugenii	94.63	0.00e+00	1912.00
IUUC-Mor-057201	Magnaporthe oryzae	46.68	1.00e-134	476.00
IUUC-Mpo-057597	Magnaporthe poae	45.92	5.00e-132	467.00
IUUC-Mtr-058273	Medicago truncatula	52.80	6.00e-126	447.00
IUUC-Mla-058888	Melampsora laricipopulina	49.25	3.00e-115	408.00
IUUC-Mvi-060320	Microbotryum violaceum	43.55	2.00e-123	438.00
IUUC-Mmr-060820	Microcebus murinus	96.91	0.00e+00	4364.00
IUUC-Mdo-062930	Monodelphis domestica	91.97	0.00e+00	4139.00
IUUC-Mmu-063601	Mus musculus	98.34	0.00e+00	4284.00
IUUC-Mac-065557	Musa acuminata	52.20	9.00e-118	419.00
IUUC-Mpu-066653	Mustela putorius furo	97.30	0.00e+00	4309.00
IUUC-Mlu-067418	Myotis lucifugus	98.42	0.00e+00	4481.00
IUUC-Nfi-068278	Neosartorya fischeri	46.46	4.00e-133	471.00
IUUC-Ncr-068813	Neurospora crassa	46.59	3.00e-135	478.00
IUUC-Nle-069418	Nomascus leucogenys	99.09	0.00e+00	4379.00
IUUC-Opr-070187	Ochotona princeps	84.02	0.00e+00	878.00
IUUC-Ont-071300	Oreochromis niloticus	83.63	0.00e+00	3710.00
IUUC-Oan-073046	Ornithorhynchus anatinus	87.97	0.00e+00	5264.00
IUUC-Ocu-074178	Oryctolagus cuniculus	98.67	0.00e+00	4460.00
IUUC-Oba-075757	Oryza barthii	51.87	3.00e-126	448.00
IUUC-Obr-076553	Oryza brachyantha	45.27	3.00e-125	445.00
IUUC-Ogl-077520	Oryza glaberrima	51.87	3.00e-126	448.00
IUUC-Ogu-078278	Oryza glumaepatula	51.87	3.00e-126	447.00
IUUC-Oin-079767	Oryza indica	51.87	3.00e-126	448.00
IUUC-Olo-080380	Oryza longistaminata	51.39	3.00e-124	441.00
IUUC-Ome-081925	Oryza meridionalis	51.39	1.00e-124	442.00
IUUC-Oni-082619	Oryza nivara	51.87	3.00e-126	448.00
IUUC-Opu-083684	Oryza punctata	51.39	1.00e-124	442.00
IUUC-Oru-084501	Oryza rufipogon	51.87	3.00e-126	448.00
IUUC-Osa-086251	Oryza sativa	51.87	9.00e-125	441.00
IUUC-Ola-087437	Oryzias latipes	85.39	0.00e+00	2132.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.12	1.00e-111	396.00
IUUC-Oga-088903	Otolemur garnettii	98.80	0.00e+00	4391.00
IUUC-Oar-090210	Ovis aries	97.35	0.00e+00	4417.00
IUUC-Ptr-090502	Pan troglodytes	99.42	0.00e+00	3403.00
IUUC-Pan-092368	Papio anubis	99.42	0.00e+00	3441.00
IUUC-Pma-094246	Petromyzon marinus	74.50	0.00e+00	1294.00
IUUC-Pno-094871	Phaeosphaeria nodorum	52.30	5.00e-134	474.00
IUUC-Ppa-095657	Physcomitrella patens	51.47	3.00e-124	441.00
IUUC-Pfo-096232	Poecilia formosa	81.01	0.00e+00	3672.00
IUUC-Pab-098583	Pongo abelii	99.54	0.00e+00	4420.00
IUUC-Pop-099613	Populus trichocarpa	53.27	1.00e-127	452.00
IUUC-Pca-100310	Procavia capensis	84.12	0.00e+00	1660.00
IUUC-Ppe-102109	Prunus persica	52.57	5.00e-126	447.00
IUUC-Pva-102116	Pteropus vampyrus	98.84	0.00e+00	4459.00
IUUC-Pgr-103465	Puccinia graminis	43.40	2.00e-126	449.00
IUUC-Ptt-103813	Puccinia triticina	41.32	5.00e-114	407.00
IUUC-Pte-104018	Pyrenophora teres	52.07	8.00e-133	470.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.29	5.00e-132	467.00
IUUC-Rno-105889	Rattus norvegicus	90.59	0.00e+00	3887.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.83	6.00e-124	440.00
IUUC-Sha-106961	Sarcophilus harrisii	90.41	0.00e+00	4084.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	46.14	5.00e-128	454.00
IUUC-Spo-108024	Schizosaccharomyces pombe	45.64	5.00e-130	460.00
IUUC-Smo-109428	Selaginella moellendorffii	51.21	7.00e-130	460.00
IUUC-Sit-110598	Setaria italica	52.57	7.00e-127	450.00
IUUC-Sly-111285	Solanum lycopersicum	51.78	4.00e-127	451.00
IUUC-Stu-112582	Solanum tuberosum	32.58	2.00e-57	218.00
IUUC-Sar-113291	Sorex araneus	92.86	0.00e+00	2740.00
IUUC-Sbi-114042	Sorghum bicolor	52.57	2.00e-127	452.00
IUUC-Sre-114958	Sporisorium reilianum	56.60	6.00e-138	484.00
IUUC-Ssc-115754	Sus scrofa	99.38	0.00e+00	4443.00
IUUC-Tru-118570	Takifugu rubripes	83.07	0.00e+00	3757.00
IUUC-Tsy-119159	Tarsius syrichta	92.89	0.00e+00	2092.00
IUUC-Tni-120836	Tetraodon nigroviridis	77.63	0.00e+00	2005.00
IUUC-Tca-121479	Theobroma cacao	51.40	6.00e-124	440.00
IUUC-Tre-121909	Trichoderma reesei	53.18	1.00e-132	469.00
IUUC-Tvi-122370	Trichoderma virens	52.94	1.00e-132	469.00
IUUC-Tae-125214	Triticum aestivum	51.16	9.00e-125	442.00
IUUC-Tme-127172	Tuber melanosporum	46.70	2.00e-138	488.00
IUUC-Tbe-127506	Tupaia belangeri	96.15	0.00e+00	1503.00
IUUC-Ttr-129253	Tursiops truncatus	91.11	0.00e+00	2203.00
IUUC-Uma-129355	Ustilago maydis	49.16	3.00e-140	491.00
IUUC-Vda-129886	Verticillium dahliae	47.35	3.00e-137	485.00
IUUC-Vpa-130708	Vicugna pacos	97.56	0.00e+00	3883.00
IUUC-Vvi-131170	Vitis vinifera	51.11	3.00e-126	446.00
IUUC-Xtr-132123	Xenopus tropicalis	83.36	0.00e+00	5167.00
IUUC-Xma-133869	Xiphophorus maculatus	81.06	0.00e+00	3684.00
IUUC-Yli-134657	Yarrowia lipolytica	45.54	3.00e-129	458.00
IUUC-Zma-135570	Zea mays	44.68	1.00e-127	452.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence