iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046930

UUCD1 version

UUC-HoS-01153

Ensembl Protein ID

ENSP00000314971.2

UniProt Accession

Q9H5J8; Q6I9Y6; TAF1D_HUMAN

Genbank Protein ID

BAB15628.1; CAG33650.1; AAH01972.1

Protein Name

TATA box-binding protein-associated factor RNA polymerase I subunit D; RNA polymerase I-specific TBP-associated factor 41 kDa; TATA box-binding protein-associated factor 1D; Transcription initiation factor SL1/TIF-IB subunit D

Genbank Nucleotide ID

AK027016; CR457369; BC001972

Gene Name

TAF1D; JOSD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000166012.15	ENST00000323981.6	ENSP00000314971.2
ENSG00000166012.15	ENST00000393259.6	ENSP00000376944.2
ENSG00000166012.15	ENST00000527169.5	ENSP00000433119.1
ENSG00000166012.15	ENST00000533794.5	ENSP00000446311.1
ENSG00000166012.15	ENST00000534770.1	ENSP00000435304.1
ENSG00000166012.15	ENST00000532455.1	ENSP00000431570.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	TRANSFAC	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/Other	DUB/Other	19615732

Organism

Homo sapiens

Functional Description
(View)

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

Protein Sequence
(Fasta)

MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR KFVRTPESVH 60
ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ PTGRPRGRPE GRRNPIYSLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCGGGAAA CCGAACGCAA CGCTCAGACT GGAAACAAAG GAGCTGGCCC AGCAACTTTC 60
CCAGAACGCA CCGCAAGCTC CCTCCTCGGT AAGTCTTTCG GAGCAAAACT GGGCAGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR027976--TAF1D

Pfam

PF15333--TAF1D

Gene Ontology

GO:0005815--C:microtubule organizing center
GO:0005654--C:nucleoplasm
GO:0005668--C:RNA polymerase transcription factor SL1 complex
GO:0003677--F:DNA binding
GO:0045815--P:positive regulation of gene expression, epigenetic
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006363--P:termination of RNA polymerase I transcription
GO:0006362--P:transcription elongation from RNA polymerase I promoter
GO:0006361--P:transcription initiation from RNA polymerase I promoter

KEGG

hsa:79101

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001853	Ailuropoda melanoleuca	66.43	8.00e-52	197.00
IUUC-Apl-003575	Anas platyrhynchos	40.83	8.00e-21	94.00
IUUC-Aca-004568	Anolis carolinensis	45.24	5.00e-27	114.00
IUUC-Ani-009409	Aspergillus nidulans	20.83	4.60e-02	32.70
IUUC-Bta-013078	Bos taurus	62.36	1.00e-40	159.00
IUUC-Cja-019808	Callithrix jacchus	89.93	8.00e-103	366.00
IUUC-Cfa-020525	Canis familiaris	63.16	4.00e-52	198.00
IUUC-Cpo-021896	Cavia porcellus	57.65	3.00e-55	208.00
IUUC-Csa-024108	Chlorocebus sabaeus	94.24	5.00e-120	423.00
IUUC-Cho-024326	Choloepus hoffmanni	60.82	6.00e-63	233.00
IUUC-Dno-029104	Dasypus novemcinctus	65.98	1.00e-61	229.00
IUUC-Dor-030151	Dipodomys ordii	58.57	1.00e-47	182.00
IUUC-Ete-033189	Echinops telfairi	64.29	3.00e-52	198.00
IUUC-Eca-034238	Equus caballus	66.00	3.00e-76	278.00
IUUC-Fca-035711	Felis catus	65.99	9.00e-63	233.00
IUUC-Fal-037067	Ficedula albicollis	47.83	3.00e-21	94.70
IUUC-Gga-040782	Gallus gallus	39.84	5.00e-22	98.60
IUUC-Ggo-045155	Gorilla gorilla	98.56	7.00e-127	446.00
IUUC-Loc-052935	Lepisosteus oculatus	29.09	1.40e-02	35.40
IUUC-Laf-054040	Loxodonta africana	66.05	6.00e-61	227.00
IUUC-Mga-059429	Meleagris gallopavo	38.79	1.00e-21	97.10
IUUC-Mmr-061505	Microcebus murinus	68.00	3.00e-68	251.00
IUUC-Mdo-062193	Monodelphis domestica	40.27	4.00e-24	104.00
IUUC-Mmu-064127	Mus musculus	52.65	6.00e-50	191.00
IUUC-Mpu-065682	Mustela putorius furo	65.47	2.00e-48	185.00
IUUC-Mlu-067425	Myotis lucifugus	64.26	9.00e-69	253.00
IUUC-Nle-069897	Nomascus leucogenys	97.48	1.00e-125	442.00
IUUC-Opr-071021	Ochotona princeps	59.36	9.00e-52	196.00
IUUC-Oan-072853	Ornithorhynchus anatinus	46.09	8.00e-28	119.00
IUUC-Ocu-074088	Oryctolagus cuniculus	61.15	1.00e-55	209.00
IUUC-Oga-089058	Otolemur garnettii	63.90	4.00e-74	271.00
IUUC-Oar-089404	Ovis aries	64.13	9.00e-46	177.00
IUUC-Ptr-091491	Pan troglodytes	98.20	2.00e-128	451.00
IUUC-Pan-092706	Papio anubis	94.60	5.00e-121	426.00
IUUC-Psi-093986	Pelodiscus sinensis	38.46	4.00e-19	89.00
IUUC-Pab-097567	Pongo abelii	98.20	5.00e-127	446.00
IUUC-Pva-103062	Pteropus vampyrus	65.11	1.00e-63	236.00
IUUC-Rno-105375	Rattus norvegicus	58.37	4.00e-50	191.00
IUUC-Sha-106880	Sarcophilus harrisii	48.84	4.00e-35	141.00
IUUC-Ssc-115335	Sus scrofa	65.31	7.00e-22	95.50
IUUC-Tgu-117094	Taeniopygia guttata	48.91	2.00e-21	95.10
IUUC-Tsy-119189	Tarsius syrichta	65.46	9.00e-64	236.00
IUUC-Tbe-128047	Tupaia belangeri	58.48	3.00e-59	221.00
IUUC-Ttr-128715	Tursiops truncatus	69.26	5.00e-76	277.00
IUUC-Vpa-130195	Vicugna pacos	60.28	2.00e-72	265.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence