iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18574499

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.30e-06	29.7	256	297

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e++   d +++l C+H+fh++C+  w        ++ +CP+C+
   Q: 256  CVICFERYkpNDIVRILTCKHFFHKNCIDPW------ILPHGTCPICK 297
           ********66444******************......999*******6 PP

Organism

Homo sapiens

Functional Description
(View)

Has E3 ubiquitin-protein ligase activity.

Protein Sequence
(Fasta)

MHLLKVGTWR NNTASSWLMK FSVLWLVSQN CCRASVVWMA YMNISFHVGN HVLSELGETG 60
VFGRSSTLKR VAGVIVPPEG KIQNACNPNT IFSRSKYSET WLALIERGGC TFTQKIKVAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCAGTATC TAGAGTTAAC AGTAGGGGAT TTATTTTTCA ATCTAAAGTT TTTCACCTCT 60
CTCTAGTAAG ACATCTGAAA CTCATAAGCC ATCTTTAAGA ATTTCTTACA AAAACATGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0051865--P:protein autoubiquitination

KEGG

hsa:168433

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001468	Ailuropoda melanoleuca	78.57	2.00e-172	598.00
IUUC-Cpo-021838	Cavia porcellus	66.76	8.00e-150	523.00
IUUC-Csa-024064	Chlorocebus sabaeus	94.95	0.00e+00	734.00
IUUC-Dno-029415	Dasypus novemcinctus	82.45	0.00e+00	627.00
IUUC-Dor-030278	Dipodomys ordii	74.54	2.00e-167	581.00
IUUC-Ete-033121	Echinops telfairi	73.53	9.00e-105	372.00
IUUC-Eca-033955	Equus caballus	78.78	5.00e-171	593.00
IUUC-Ggo-045319	Gorilla gorilla	98.67	0.00e+00	726.00
IUUC-Mmu-063716	Mus musculus	73.94	6.00e-170	590.00
IUUC-Mlu-068071	Myotis lucifugus	74.14	1.00e-162	565.00
IUUC-Opr-070767	Ochotona princeps	79.64	5.00e-159	553.00
IUUC-Ocu-074834	Oryctolagus cuniculus	80.80	0.00e+00	637.00
IUUC-Oga-088182	Otolemur garnettii	80.05	0.00e+00	629.00
IUUC-Oar-089395	Ovis aries	75.86	3.00e-175	607.00
IUUC-Pva-103079	Pteropus vampyrus	77.57	5.00e-176	610.00
IUUC-Sha-106598	Sarcophilus harrisii	75.00	1.00e-167	582.00
IUUC-Tbe-127498	Tupaia belangeri	79.73	3.00e-180	624.00
IUUC-Ttr-129094	Tursiops truncatus	77.66	3.00e-174	604.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence