iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	DrugBank	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/PHD	PHD	12049732; 16472679

Classification

Family	E-value	Score	Start	End
E3 activity/RING/PHD	2.70e-16	61.2	440	494

Active Site

Position(s)	Description	Evidence
1369	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10027}

Domain Profile

E3 activity/RING/PHD

   S: 1    ekvClvCgeggedekslveCek.CrewfHpaClklsveeelpnsekwiCpkCrsk 54
           e++C++C  g+ de+sl++Ce+ Cr+++H++C+++++ee+++n+e++iCp Crsk
   Q: 440  EQMCPICLLGMLDEESLTVCEDgCRNKLHHHCMSIWAEECRRNREPLICPLCRSK 494
           69**************************************************985 PP

Organism

Homo sapiens

Functional Description
(View)

Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Protein Sequence
(Fasta)

MAAAAGNRAS SSGFPGARAT SPEAGGGGGA LKASSAPAAA AGLLREAGSG GRERADWRRR 60
QLRKVRSVEL DQLPEQPLFL AASPPASSTS PSPEPADAAG SGTGFQPVAV PPPHGAASRG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG CGGCGGGGAA TCGCGCCTCG TCGTCGGGAT TCCCGGGCGC CAGGGCTACG 60
AGCCCTGAGG CAGGCGGCGG CGGAGGAGCC CTCAAGGCGA GCAGCGCGCC CGCGGCTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016024--ARM-type_fold
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR007527--Znf_SWIM

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50089--ZF_RING_2
PS50966--ZF_SWIM

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0004702--F:signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0008270--F:zinc ion binding
GO:0030036--P:actin cytoskeleton organization
GO:0006915--P:apoptotic process
GO:0071260--P:cellular response to mechanical stimulus
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0006468--P:protein phosphorylation

KEGG

hsa:4214

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002233	Ailuropoda melanoleuca	93.93	0.00e+00	2281.00
IUUC-Apl-003550	Anas platyrhynchos	71.64	3.00e-61	228.00
IUUC-Aca-004258	Anolis carolinensis	83.06	0.00e+00	1968.00
IUUC-Ame-011412	Astyanax mexicanus	70.83	0.00e+00	1711.00
IUUC-Bta-013046	Bos taurus	93.08	0.00e+00	2303.00
IUUC-Cja-019060	Callithrix jacchus	97.78	0.00e+00	2315.00
IUUC-Cfa-020837	Canis familiaris	93.35	0.00e+00	2244.00
IUUC-Cpo-022141	Cavia porcellus	93.80	0.00e+00	2254.00
IUUC-Csa-023082	Chlorocebus sabaeus	97.63	0.00e+00	2353.00
IUUC-Cho-024597	Choloepus hoffmanni	86.74	1.00e-167	584.00
IUUC-Cin-025107	Ciona intestinalis	57.07	1.00e-59	222.00
IUUC-Csv-026034	Ciona savignyi	60.10	8.00e-129	455.00
IUUC-Dre-028821	Danio rerio	71.09	0.00e+00	1727.00
IUUC-Dno-029178	Dasypus novemcinctus	91.90	0.00e+00	2353.00
IUUC-Dor-030534	Dipodomys ordii	92.54	0.00e+00	2306.00
IUUC-Ete-032843	Echinops telfairi	91.09	0.00e+00	2078.00
IUUC-Eca-033650	Equus caballus	92.75	0.00e+00	2185.00
IUUC-Eeu-034569	Erinaceus europaeus	87.77	1.00e-95	345.00
IUUC-Fca-035802	Felis catus	93.56	0.00e+00	2347.00
IUUC-Fal-037259	Ficedula albicollis	83.73	0.00e+00	1990.00
IUUC-Gga-040810	Gallus gallus	84.78	0.00e+00	2041.00
IUUC-Ggo-045102	Gorilla gorilla	98.47	0.00e+00	2381.00
IUUC-Itr-048840	Ictidomys tridecemlineatus	95.64	0.00e+00	1827.00
IUUC-Lch-050377	Latimeria chalumnae	77.27	0.00e+00	1701.00
IUUC-Loc-052431	Lepisosteus oculatus	74.91	0.00e+00	1800.00
IUUC-Laf-053894	Loxodonta africana	91.06	0.00e+00	2261.00
IUUC-Mcc-055263	Macaca mulatta	98.15	0.00e+00	2362.00
IUUC-Meu-056425	Macropus eugenii	71.68	0.00e+00	674.00
IUUC-Mga-060098	Meleagris gallopavo	73.18	0.00e+00	1258.00
IUUC-Mmr-061686	Microcebus murinus	87.91	0.00e+00	2207.00
IUUC-Mdo-062008	Monodelphis domestica	83.73	0.00e+00	2056.00
IUUC-Mmu-063424	Mus musculus	88.84	0.00e+00	2269.00
IUUC-Mpu-066599	Mustela putorius furo	92.96	0.00e+00	2256.00
IUUC-Mlu-067383	Myotis lucifugus	83.11	0.00e+00	1935.00
IUUC-Nle-069023	Nomascus leucogenys	98.59	0.00e+00	2341.00
IUUC-Opr-070921	Ochotona princeps	84.26	0.00e+00	1595.00
IUUC-Oan-073487	Ornithorhynchus anatinus	84.16	0.00e+00	2067.00
IUUC-Ocu-074697	Oryctolagus cuniculus	94.08	0.00e+00	2276.00
IUUC-Oga-088673	Otolemur garnettii	93.95	0.00e+00	2259.00
IUUC-Oar-089502	Ovis aries	94.17	0.00e+00	2226.00
IUUC-Ptr-090480	Pan troglodytes	99.45	0.00e+00	2478.00
IUUC-Pan-092294	Papio anubis	97.81	0.00e+00	2428.00
IUUC-Psi-093454	Pelodiscus sinensis	98.79	3.00e-139	487.00
IUUC-Pma-094215	Petromyzon marinus	62.73	1.00e-162	566.00
IUUC-Pab-097948	Pongo abelii	98.23	0.00e+00	2463.00
IUUC-Pca-101118	Procavia capensis	88.35	0.00e+00	1937.00
IUUC-Pva-102761	Pteropus vampyrus	92.04	0.00e+00	2233.00
IUUC-Rno-105787	Rattus norvegicus	89.65	0.00e+00	2249.00
IUUC-Sha-106698	Sarcophilus harrisii	86.93	0.00e+00	2070.00
IUUC-Sar-113569	Sorex araneus	91.16	0.00e+00	1488.00
IUUC-Ssc-115862	Sus scrofa	94.38	0.00e+00	2371.00
IUUC-Tgu-117455	Taeniopygia guttata	84.11	0.00e+00	1999.00
IUUC-Tsy-119272	Tarsius syrichta	92.90	0.00e+00	2148.00
IUUC-Tbe-127403	Tupaia belangeri	87.05	0.00e+00	1332.00
IUUC-Ttr-128576	Tursiops truncatus	92.83	0.00e+00	2156.00
IUUC-Vpa-130139	Vicugna pacos	94.97	0.00e+00	2289.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence