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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064395
Ensembl Protein ID ENSMUSP00000004959.2
UniProt Accession Q9CX99; Q0VBE3; Q3U545; GRAP_MOUSE
Genbank Protein ID BAB31222.1; BAE32235.1; CAI24871.1; AAI20675.1; AAI20677.1
Protein Name GRB2-related adapter protein
Genbank Nucleotide ID AK018457; AK153888; AL596209; BC120674; BC120676
Gene Name Grap
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000004837.2 ENSMUST00000004959.2 ENSMUSP00000004959.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 8.20e-30 103.7 4 54
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +ly+++a+++deL ++kGd+++++ + e d++W k+  el+g +G++P+n+++
   Q: 4    VALYSFQATESDELAFNKGDTLKIL-NMEDDQNWYKA--ELRGAEGFVPKNYIR 54
           58***********************.99*******99..9************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
 Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
Protein Sequence
(Fasta)
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK NYIRVKPHPW 60
YSGRISRQLA EETLMKRNHL GAFLIRESES SPGEFSVSVN YGDQVQHFKV LREASGKYFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064395|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAACAAAGG AAGTGGTCCT CTCCTGCAGG AAGCAGGAAG CTGTAGCTGC TGGGTCCTCG 60
GCTGAAGCCC AGGGACAGTG GGATGGAGTC CGTGGCCCTG TACAGCTTCC AGGCTACCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064395|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50001--SH2
PS50002--SH3
Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG mmu:71520
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001277 Ailuropoda melanoleuca 90.32 2.00e-116 411.00
IUUC-Apl-003499 Anas platyrhynchos 61.75 3.00e-72 264.00
IUUC-Aca-004922 Anolis carolinensis 65.90 1.00e-86 312.00
IUUC-Bta-012909 Bos taurus 89.86 2.00e-116 411.00
IUUC-Cja-018796 Callithrix jacchus 90.32 3.00e-117 413.00
IUUC-Cfa-021023 Canis familiaris 90.32 1.00e-117 415.00
IUUC-Cpo-021502 Cavia porcellus 92.17 1.00e-118 418.00
IUUC-Csa-024099 Chlorocebus sabaeus 91.24 2.00e-117 414.00
IUUC-Dno-029057 Dasypus novemcinctus 86.23 3.00e-83 300.00
IUUC-Eca-033722 Equus caballus 77.21 7.00e-98 349.00
IUUC-Eeu-035125 Erinaceus europaeus 77.78 6.00e-44 168.00
IUUC-Fca-036087 Felis catus 91.24 1.00e-117 415.00
IUUC-Fal-037633 Ficedula albicollis 76.28 2.00e-96 345.00
IUUC-Gga-041204 Gallus gallus 74.42 4.00e-95 340.00
IUUC-Ggo-044579 Gorilla gorilla 92.17 3.00e-119 420.00
IUUC-Hsa-045927 Homo sapiens 92.17 3.00e-119 420.00
IUUC-Laf-053794 Loxodonta africana 91.24 1.00e-119 422.00
IUUC-Mcc-055527 Macaca mulatta 91.71 3.00e-118 417.00
IUUC-Meu-056608 Macropus eugenii 79.58 2.00e-84 304.00
IUUC-Mmr-060743 Microcebus murinus 82.03 4.00e-103 366.00
IUUC-Mdo-063025 Monodelphis domestica 82.49 6.00e-109 386.00
IUUC-Mpu-066088 Mustela putorius furo 89.40 6.00e-115 406.00
IUUC-Mlu-067003 Myotis lucifugus 89.40 1.00e-115 408.00
IUUC-Opr-071051 Ochotona princeps 68.20 1.00e-78 285.00
IUUC-Ont-071576 Oreochromis niloticus 59.26 1.00e-75 275.00
IUUC-Oan-073107 Ornithorhynchus anatinus 65.07 4.00e-80 290.00
IUUC-Ocu-074963 Oryctolagus cuniculus 89.45 1.00e-104 372.00
IUUC-Ola-086725 Oryzias latipes 56.31 1.00e-70 259.00
IUUC-Oga-088158 Otolemur garnettii 89.86 3.00e-117 414.00
IUUC-Oar-090223 Ovis aries 87.10 4.00e-112 397.00
IUUC-Pan-092422 Papio anubis 92.17 6.00e-119 419.00
IUUC-Psi-093655 Pelodiscus sinensis 75.23 1.00e-97 348.00
IUUC-Pca-100573 Procavia capensis 88.40 4.00e-96 343.00
IUUC-Pva-102471 Pteropus vampyrus 89.01 5.00e-101 359.00
IUUC-Rno-105932 Rattus norvegicus 97.70 2.00e-126 444.00
IUUC-Sha-107209 Sarcophilus harrisii 81.11 3.00e-98 350.00
IUUC-Tni-120563 Tetraodon nigroviridis 55.56 3.00e-67 248.00
IUUC-Ttr-128195 Tursiops truncatus 90.78 1.00e-114 404.00
Created Date 25-Jun-2017

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