iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098709

Ensembl Protein ID

ENSPPYP00000009686.2

UniProt Accession

Q5R4J7; GRB2_PONAB

Genbank Protein ID

CAH92874.1; CAH93319.1

Protein Name

Growth factor receptor-bound protein 2; Adapter protein GRB2; SH2/SH3 adapter GRB2

Genbank Nucleotide ID

CR860761; CR861250

Gene Name

GRB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000008626.2	ENSPPYT00000010071.2	ENSPPYP00000009686.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.80e-37	125.1	157	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  +vq+l+d+++q+d+eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 157  QPTYVQALFDFDPQEDGELGFRRGDFIHVM--DNSDPNWWKG--ACHGQTGMFPRNYVTPVN 214
           5689*************************9..9*********..8**************997 PP

Organism

Pongo abelii

Functional Description
(View)

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

Protein Sequence
(Fasta)

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGTTCCCTA CCTGCAGGGG CCCGGCTGAG GAGGAGCGCT TGCGCTCTGG GCCTTTTCCG 60
CCGAGGGAAG TCTCGCGGGG GCGGGGCGGG GCGGGGCGGG GCCTCGTGGA GAAGTTCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0070436--C:Grb2-EGFR complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0012506--C:vesicle membrane
GO:0003723--F:RNA binding
GO:0017124--F:SH3 domain binding
GO:0048646--P:anatomical structure formation involved in morphogenesis
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0030154--P:cell differentiation
GO:0071479--P:cellular response to ionizing radiation
GO:0008286--P:insulin receptor signaling pathway
GO:0030838--P:positive regulation of actin filament polymerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0009967--P:positive regulation of signal transduction
GO:0031623--P:receptor internalization
GO:0043408--P:regulation of MAPK cascade
GO:0042770--P:signal transduction in response to DNA damage

KEGG

pon:100173972

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	99.48	2.00e-114	404.00
IUUC-Apl-003322	Anas platyrhynchos	97.38	6.00e-112	395.00
IUUC-Aca-005193	Anolis carolinensis	97.24	3.00e-127	446.00
IUUC-Ago-007965	Ashbya gossypii	48.15	1.00e-12	66.60
IUUC-Ame-010929	Astyanax mexicanus	91.24	1.00e-120	424.00
IUUC-Bta-012932	Bos taurus	100.00	9.00e-130	455.00
IUUC-Cel-018665	Caenorhabditis elegans	58.06	1.00e-71	262.00
IUUC-Cja-019225	Callithrix jacchus	100.00	9.00e-130	455.00
IUUC-Cfa-020887	Canis familiaris	100.00	9.00e-130	455.00
IUUC-Cpo-022488	Cavia porcellus	100.00	9.00e-130	455.00
IUUC-Csa-023326	Chlorocebus sabaeus	100.00	9.00e-130	455.00
IUUC-Cho-024953	Choloepus hoffmanni	82.03	5.00e-98	349.00
IUUC-Cin-025144	Ciona intestinalis	63.21	8.00e-74	269.00
IUUC-Csv-026210	Ciona savignyi	60.66	2.00e-71	261.00
IUUC-Dre-028403	Danio rerio	94.93	1.00e-124	437.00
IUUC-Dno-029187	Dasypus novemcinctus	98.62	2.00e-128	451.00
IUUC-Dor-030763	Dipodomys ordii	100.00	9.00e-130	455.00
IUUC-Dme-031741	Drosophila melanogaster	65.57	2.00e-78	285.00
IUUC-Ete-032354	Echinops telfairi	69.91	2.00e-82	298.00
IUUC-Eca-033222	Equus caballus	100.00	9.00e-130	455.00
IUUC-Eeu-034513	Erinaceus europaeus	73.73	3.00e-88	317.00
IUUC-Fca-036294	Felis catus	100.00	9.00e-130	455.00
IUUC-Fal-037130	Ficedula albicollis	96.77	1.00e-125	441.00
IUUC-Gmo-039546	Gadus morhua	93.55	6.00e-123	432.00
IUUC-Gga-041139	Gallus gallus	97.70	3.00e-127	447.00
IUUC-Gac-041968	Gasterosteus aculeatus	94.47	7.00e-124	435.00
IUUC-Ggo-044562	Gorilla gorilla	100.00	9.00e-130	455.00
IUUC-Hsa-046730	Homo sapiens	100.00	9.00e-130	455.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	100.00	9.00e-130	455.00
IUUC-Lch-050230	Latimeria chalumnae	95.52	2.00e-73	269.00
IUUC-Loc-052723	Lepisosteus oculatus	95.85	2.00e-125	441.00
IUUC-Laf-053774	Loxodonta africana	98.62	2.00e-128	451.00
IUUC-Mcc-054603	Macaca mulatta	100.00	9.00e-130	455.00
IUUC-Meu-056173	Macropus eugenii	80.65	4.00e-100	356.00
IUUC-Mga-059950	Meleagris gallopavo	97.70	3.00e-127	447.00
IUUC-Mmr-060878	Microcebus murinus	100.00	9.00e-130	455.00
IUUC-Mdo-062454	Monodelphis domestica	97.70	3.00e-127	447.00
IUUC-Mmu-063913	Mus musculus	99.54	3.00e-129	453.00
IUUC-Mpu-066125	Mustela putorius furo	100.00	9.00e-130	455.00
IUUC-Mlu-068007	Myotis lucifugus	100.00	9.00e-130	455.00
IUUC-Nle-069101	Nomascus leucogenys	100.00	9.00e-130	455.00
IUUC-Opr-071075	Ochotona princeps	100.00	9.00e-130	455.00
IUUC-Ont-072253	Oreochromis niloticus	91.24	3.00e-120	423.00
IUUC-Oan-073107	Ornithorhynchus anatinus	50.00	5.00e-57	213.00
IUUC-Ocu-074583	Oryctolagus cuniculus	100.00	9.00e-130	455.00
IUUC-Ola-086586	Oryzias latipes	95.51	4.00e-86	311.00
IUUC-Oga-089047	Otolemur garnettii	100.00	9.00e-130	455.00
IUUC-Oar-089904	Ovis aries	92.66	2.00e-118	417.00
IUUC-Ptr-090678	Pan troglodytes	100.00	9.00e-130	455.00
IUUC-Pan-092090	Papio anubis	100.00	9.00e-130	455.00
IUUC-Psi-093765	Pelodiscus sinensis	97.24	1.00e-126	445.00
IUUC-Pma-094650	Petromyzon marinus	85.25	1.00e-111	395.00
IUUC-Pfo-096131	Poecilia formosa	94.01	1.00e-123	435.00
IUUC-Pca-100581	Procavia capensis	98.95	2.00e-113	400.00
IUUC-Pva-103066	Pteropus vampyrus	100.00	9.00e-130	455.00
IUUC-Rno-105224	Rattus norvegicus	100.00	9.00e-130	455.00
IUUC-Sce-106302	Saccharomyces cerevisiae	51.85	1.00e-15	76.30
IUUC-Sha-107247	Sarcophilus harrisii	97.91	2.00e-112	397.00
IUUC-Sar-113277	Sorex araneus	84.33	8.00e-104	369.00
IUUC-Ssc-115478	Sus scrofa	100.00	9.00e-130	455.00
IUUC-Tgu-117479	Taeniopygia guttata	96.31	2.00e-125	441.00
IUUC-Tru-118451	Takifugu rubripes	84.72	4.00e-107	380.00
IUUC-Tsy-119029	Tarsius syrichta	93.75	1.00e-83	301.00
IUUC-Tni-120563	Tetraodon nigroviridis	50.70	1.00e-62	232.00
IUUC-Tbe-128097	Tupaia belangeri	99.54	1.00e-128	451.00
IUUC-Ttr-128871	Tursiops truncatus	100.00	4.00e-90	323.00
IUUC-Vpa-130754	Vicugna pacos	100.00	9.00e-130	455.00
IUUC-Xtr-132275	Xenopus tropicalis	91.70	4.00e-123	433.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence