iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042181

UUCD1 version

UUC-GaA-00779

Ensembl Protein ID

ENSGACP00000020039.1

UniProt Accession

G3PR04; G3PR04_GASAC

Protein Name

Uncharacterized protein

Gene Name

HECW2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000015192.1	ENSGACT00000020078.1	ENSGACP00000020039.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-120	402.2	1200	1532

Active Site

Position(s)	Description	Evidence
1500	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1200 DLQRSKLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1285
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   die++ ldltf+v+ee++g+++e+eLk gG+nipV ++Nk+eY+++
   Q: 1286 AFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDN---DIEDM-LDLTFTVNEEVFGQITERELKAGGANIPVSEKNKKEYIER 1368
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q++++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1369 MVKWRIERGVVQQTDSLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1455
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ek+l+A+eet+ F+l+
   Q: 1456 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKVSALPRAHTCFNRLDLPPYPSFSMLYEKMLTAVEETSTFGLE 1532
           **************************************************************************985 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

TNGSAREHLL AVRRRTPHTR PYTIGPDNLR TLSGSQQETA GVGLQRANSD TDLVTSDSRS 60
SLAASSYQLT LGHSHLVISW DIKEEVDATD WIGLYHIDET SVANVWDSKN RGVNGTQRGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAACGGCA GCGCCCGGGA GCACCTGCTG GCGGTGCGTC GGCGCACCCC CCACACCCGG 60
CCGTACACGA TTGGCCCGGA TAACCTCCGC ACCCTGTCTG ATCAGGGCCC GGTCCAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003935	Anas platyrhynchos	84.53	0.00e+00	1412.00
IUUC-Ame-010893	Astyanax mexicanus	91.14	0.00e+00	1330.00
IUUC-Bta-013093	Bos taurus	88.32	0.00e+00	1397.00
IUUC-Cel-018137	Caenorhabditis elegans	29.82	1.00e-102	367.00
IUUC-Cfa-021232	Canis familiaris	88.58	0.00e+00	1396.00
IUUC-Cpo-021770	Cavia porcellus	88.32	0.00e+00	1423.00
IUUC-Cho-024512	Choloepus hoffmanni	78.74	0.00e+00	1196.00
IUUC-Csv-026127	Ciona savignyi	66.42	2.00e-154	538.00
IUUC-Dre-028275	Danio rerio	88.07	0.00e+00	1437.00
IUUC-Dme-032217	Drosophila melanogaster	70.88	0.00e+00	650.00
IUUC-Eca-033978	Equus caballus	88.32	0.00e+00	1394.00
IUUC-Fal-037110	Ficedula albicollis	84.91	0.00e+00	1406.00
IUUC-Lch-050526	Latimeria chalumnae	87.39	0.00e+00	1396.00
IUUC-Loc-052648	Lepisosteus oculatus	81.84	0.00e+00	1430.00
IUUC-Meu-056356	Macropus eugenii	76.02	0.00e+00	751.00
IUUC-Mmr-061526	Microcebus murinus	88.58	0.00e+00	1404.00
IUUC-Mpu-065835	Mustela putorius furo	87.87	0.00e+00	1384.00
IUUC-Ont-071345	Oreochromis niloticus	79.14	0.00e+00	1502.00
IUUC-Oga-088177	Otolemur garnettii	88.47	0.00e+00	1402.00
IUUC-Pfo-096520	Poecilia formosa	73.21	0.00e+00	2161.00
IUUC-Pva-102324	Pteropus vampyrus	87.96	0.00e+00	1388.00
IUUC-Sha-106985	Sarcophilus harrisii	86.09	0.00e+00	1333.00
IUUC-Sar-113505	Sorex araneus	85.30	0.00e+00	1317.00
IUUC-Ssc-115534	Sus scrofa	96.41	0.00e+00	738.00
IUUC-Tgu-117078	Taeniopygia guttata	84.60	0.00e+00	1404.00
IUUC-Tru-118671	Takifugu rubripes	76.05	0.00e+00	2226.00
IUUC-Tni-120619	Tetraodon nigroviridis	93.56	0.00e+00	1468.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence