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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018682
UUCD1 version UUC-CaE-00148
Ensembl Protein ID F49B2.5
UniProt Accession O45539; SRC2_CAEEL
Genbank Protein ID CAB04427.2
Protein Name Tyrosine protein-kinase src-2; SRC oncogene related protein 2
Genbank Nucleotide ID BX284601
Gene Name src-2; kin-22; F49B2.5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00005078 F49B2.5 F49B2.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
iRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.40e-12 46.9 61 115
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            + +l++y+a +dd+L++kk d+++++  +++ ++W+ + ++++g+ G +P+n+v++
   Q: 61   NFVALFQYDARTDDDLSFKKDDILEIL--NDTQGDWWFARHKATGRTGYIPSNYVAR 115
           6789***********************..78889*********************87 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase which may play a role in larval and pharynx development. Unlike src-1, does not play a role in embryonic development.
 Non-receptor tyrosine-protein kinase which may play a role in larval and pharynx development. Unlike src-1, does not play a role in embryonic development.
Protein Sequence
(Fasta)
MGSCIGKEDP PPGATSPVHT SSTLGRESLP SHPRIPSIGP IAASSSGNTI DKNQNISQSA 60
NFVALFQYDA RTDDDLSFKK DDILEILNDT QGDWWFARHK ATGRTGYIPS NYVAREKSIE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018682|UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACCTCCCAA ATCAAAAAAC TGACGACACC AGGATCGTCC GTTCCTCCCC ATGGGATCCT 60
GTATTGGAAA AGAGGATCCA CCGCCTGGTG CAACGTCACC AGTCCACACG TCATCCACGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018682|UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0464--Manganese
KW-0479--Metal-binding
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0060465--P:pharynx development
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG cel:CELE_F49B2.5
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002009 Ailuropoda melanoleuca 57.68 4.00e-150 523.00
IUUC-Apl-004032 Anas platyrhynchos 58.17 8.00e-151 525.00
IUUC-Aca-005065 Anolis carolinensis 53.78 3.00e-151 527.00
IUUC-Ame-011533 Astyanax mexicanus 57.91 3.00e-149 520.00
IUUC-Bta-012645 Bos taurus 57.68 4.00e-150 523.00
IUUC-Bol-015857 Brassica oleracea 33.33 6.00e-21 94.40
IUUC-Cja-019885 Callithrix jacchus 54.68 6.00e-153 532.00
IUUC-Cfa-021163 Canis familiaris 57.68 4.00e-150 523.00
IUUC-Cpo-022315 Cavia porcellus 57.68 4.00e-150 523.00
IUUC-Cre-022669 Chlamydomonas reinhardtii 26.46 4.00e-17 81.30
IUUC-Csa-023721 Chlorocebus sabaeus 57.68 4.00e-150 523.00
IUUC-Cho-025014 Choloepus hoffmanni 57.68 4.00e-150 523.00
IUUC-Cin-025605 Ciona intestinalis 55.90 4.00e-153 533.00
IUUC-Csv-026029 Ciona savignyi 50.48 2.00e-131 461.00
IUUC-Dre-028274 Danio rerio 57.05 4.00e-153 533.00
IUUC-Dno-029689 Dasypus novemcinctus 53.20 2.00e-148 517.00
IUUC-Dor-030202 Dipodomys ordii 57.72 2.00e-147 514.00
IUUC-Dme-031976 Drosophila melanogaster 63.56 0.00e+00 635.00
IUUC-Ete-033170 Echinops telfairi 54.29 3.00e-139 487.00
IUUC-Eca-034157 Equus caballus 57.94 4.00e-149 520.00
IUUC-Eeu-035004 Erinaceus europaeus 44.88 9.00e-91 325.00
IUUC-Fca-035582 Felis catus 57.68 4.00e-150 523.00
IUUC-Fal-037461 Ficedula albicollis 55.24 3.00e-151 526.00
IUUC-Gmo-038992 Gadus morhua 54.83 1.00e-149 522.00
IUUC-Gga-041107 Gallus gallus 58.17 1.00e-150 525.00
IUUC-Gac-042461 Gasterosteus aculeatus 55.46 3.00e-149 520.00
IUUC-Ggo-044469 Gorilla gorilla 53.48 2.00e-150 524.00
IUUC-Hsa-045723 Homo sapiens 57.68 4.00e-150 523.00
IUUC-Itr-048519 Ictidomys tridecemlineatus 57.68 4.00e-150 523.00
IUUC-Lch-049825 Latimeria chalumnae 57.68 1.00e-149 521.00
IUUC-Lpe-051423 Leersia perrieri 28.98 3.00e-17 82.80
IUUC-Loc-052913 Lepisosteus oculatus 57.08 3.00e-154 537.00
IUUC-Laf-053659 Loxodonta africana 57.46 2.00e-149 521.00
IUUC-Mcc-055626 Macaca mulatta 57.72 1.00e-148 518.00
IUUC-Meu-056155 Macropus eugenii 54.14 7.00e-133 465.00
IUUC-Mga-059310 Meleagris gallopavo 58.17 1.00e-150 525.00
IUUC-Mmr-061652 Microcebus murinus 58.17 3.00e-150 523.00
IUUC-Mdo-062963 Monodelphis domestica 58.39 1.00e-151 528.00
IUUC-Mmu-063896 Mus musculus 57.68 4.00e-150 523.00
IUUC-Mpu-066333 Mustela putorius furo 57.68 3.00e-150 523.00
IUUC-Mlu-067315 Myotis lucifugus 57.68 4.00e-150 523.00
IUUC-Nle-069786 Nomascus leucogenys 54.68 5.00e-152 529.00
IUUC-Opr-070705 Ochotona princeps 48.16 3.00e-135 473.00
IUUC-Ont-072417 Oreochromis niloticus 57.52 6.00e-161 559.00
IUUC-Oan-073714 Ornithorhynchus anatinus 57.68 1.00e-149 521.00
IUUC-Ocu-074284 Oryctolagus cuniculus 57.68 4.00e-150 523.00
IUUC-Oba-075594 Oryza barthii 30.04 7.00e-18 84.70
IUUC-Ogu-078119 Oryza glumaepatula 32.56 2.00e-19 89.00
IUUC-Olo-080520 Oryza longistaminata 30.45 8.00e-19 87.80
IUUC-Ola-086419 Oryzias latipes 56.83 4.00e-156 543.00
IUUC-Oga-087957 Otolemur garnettii 58.17 4.00e-150 523.00
IUUC-Oar-089408 Ovis aries 57.68 4.00e-150 523.00
IUUC-Ptr-091068 Pan troglodytes 57.68 4.00e-150 523.00
IUUC-Pan-092732 Papio anubis 54.90 3.00e-151 527.00
IUUC-Psi-093310 Pelodiscus sinensis 55.65 1.00e-151 528.00
IUUC-Pma-094230 Petromyzon marinus 53.73 5.00e-148 516.00
IUUC-Pfo-096035 Poecilia formosa 53.73 4.00e-150 523.00
IUUC-Pab-097673 Pongo abelii 57.46 2.00e-149 520.00
IUUC-Pca-100245 Procavia capensis 57.68 4.00e-150 523.00
IUUC-Pva-102645 Pteropus vampyrus 57.68 4.00e-150 523.00
IUUC-Rno-105372 Rattus norvegicus 57.68 4.00e-150 523.00
IUUC-Sha-107637 Sarcophilus harrisii 57.68 5.00e-150 523.00
IUUC-Sly-111920 Solanum lycopersicum 25.88 6.00e-18 84.70
IUUC-Stu-112331 Solanum tuberosum 26.67 4.00e-18 85.50
IUUC-Sar-113364 Sorex araneus 54.59 8.00e-138 482.00
IUUC-Ssc-116389 Sus scrofa 57.68 4.00e-150 523.00
IUUC-Tgu-117380 Taeniopygia guttata 55.24 3.00e-151 526.00
IUUC-Tru-118241 Takifugu rubripes 55.32 2.00e-150 524.00
IUUC-Tsy-119440 Tarsius syrichta 50.22 2.00e-131 461.00
IUUC-Tni-120512 Tetraodon nigroviridis 57.96 2.00e-162 563.00
IUUC-Tbe-127707 Tupaia belangeri 57.24 3.00e-147 513.00
IUUC-Ttr-128817 Tursiops truncatus 54.29 8.00e-152 528.00
IUUC-Vpa-130060 Vicugna pacos 57.72 2.00e-148 518.00
IUUC-Xtr-132322 Xenopus tropicalis 57.72 1.00e-149 521.00
Created Date 25-Jun-2017

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