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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046237
UUCD1 version UUC-HoS-00319
Ensembl Protein ID ENSP00000248139.3
UniProt Accession Q96S21; A2IDE2; D3DU54; O60795; Q4TT41; Q5PXE8; Q6PIU5; RB40C_HUMAN
Genbank Protein ID AAV83924.1; AAK61236.1; CAB06484.2; CAB06484.2; CAM26443.1; CAM26443.1; EAW85791.1; EAW85792.1; EAW85793.1; EAW85794.1; AAH28696.1
Protein Name Ras-related protein Rab-40C; Rar-like protein; Ras-like protein family member 8C; SOCS box-containing protein RAR3
Genbank Nucleotide ID AY823398; AE006464; Z84479; Z98883; Z98883; Z84479; CH471112; CH471112; CH471112; CH471112; BC028696
Gene Name RAB40C; RARL; RASL8C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000197562.9 ENST00000248139.7 ENSP00000248139.3
ENSG00000197562.9 ENST00000565511.5 ENSP00000457845.1
ENSG00000197562.9 ENST00000509637.6 ENSP00000455232.1
ENSG00000197562.9 ENST00000563109.1 ENSP00000455225.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 15601820
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 5.40e-16 59.9 180 227
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           ++k+w ++++++SLq+LC++aI++c++ + +   dkLPLP  +k++L+++++
   Q: 180  MEKIW-RPNRVFSLQDLCCRAIVSCTPVHLI---DKLPLPVTIKSHLKSFSM 227
           67899.**********************888...***************976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MGSQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG 60
RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046237|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCCGGGGC CACCCCGCCG CTCCCTCCGA GGGTTCTGCG GAAGCAGGCG GCACAGCCTG 60
CGAGGGGCTT TCGTTTCCCG GACTCAGCCG CATCGCCTCG GCTCGGGCGC GCCTGCATCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046237|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR001496--SOCS_box
PROSITE

PS51419--RAB
PS50225--SOCS
Pfam

PF00071--Ras
PF07525--SOCS_box
SMART

SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005768--C:endosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0008021--C:synaptic vesicle
GO:0019003--F:GDP binding
GO:0005525--F:GTP binding
GO:0072659--P:protein localization to plasma membrane
GO:0009306--P:protein secretion
GO:0016567--P:protein ubiquitination
GO:0007264--P:small GTPase mediated signal transduction
GO:0006904--P:vesicle docking involved in exocytosis
KEGG hsa:57799
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001616 Ailuropoda melanoleuca 98.14 2.00e-142 498.00
IUUC-Apl-003799 Anas platyrhynchos 90.20 1.00e-129 455.00
IUUC-Ame-011203 Astyanax mexicanus 93.95 2.00e-152 531.00
IUUC-Bta-013490 Bos taurus 99.64 3.00e-151 527.00
IUUC-Cja-019990 Callithrix jacchus 99.29 4.00e-150 523.00
IUUC-Cpo-022437 Cavia porcellus 98.53 7.00e-143 499.00
IUUC-Csa-024147 Chlorocebus sabaeus 100.00 1.00e-151 528.00
IUUC-Dre-027427 Danio rerio 93.59 3.00e-152 530.00
IUUC-Dno-029998 Dasypus novemcinctus 92.80 4.00e-116 413.00
IUUC-Dor-030584 Dipodomys ordii 89.70 1.00e-108 385.00
IUUC-Dme-031810 Drosophila melanogaster 69.20 3.00e-94 337.00
IUUC-Ete-033080 Echinops telfairi 96.80 9.00e-143 499.00
IUUC-Eca-033423 Equus caballus 99.15 5.00e-126 443.00
IUUC-Eeu-034590 Erinaceus europaeus 89.27 1.00e-111 395.00
IUUC-Fca-035697 Felis catus 99.15 1.00e-121 428.00
IUUC-Fal-037070 Ficedula albicollis 97.51 2.00e-150 525.00
IUUC-Gmo-039605 Gadus morhua 92.53 1.00e-150 525.00
IUUC-Gga-040343 Gallus gallus 97.51 2.00e-150 525.00
IUUC-Gac-041833 Gasterosteus aculeatus 88.81 1.00e-143 501.00
IUUC-Ggo-045131 Gorilla gorilla 92.53 4.00e-134 470.00
IUUC-Itr-048902 Ictidomys tridecemlineatus 98.93 3.00e-151 527.00
IUUC-Lch-050193 Latimeria chalumnae 95.02 3.00e-153 534.00
IUUC-Loc-052243 Lepisosteus oculatus 93.59 2.00e-152 531.00
IUUC-Laf-054435 Loxodonta africana 97.15 5.00e-150 523.00
IUUC-Mcc-055337 Macaca mulatta 99.64 2.00e-150 525.00
IUUC-Meu-056731 Macropus eugenii 97.60 1.00e-80 292.00
IUUC-Mmr-061380 Microcebus murinus 99.28 4.00e-150 523.00
IUUC-Mdo-062438 Monodelphis domestica 97.51 2.00e-150 524.00
IUUC-Mmu-064046 Mus musculus 99.29 3.00e-151 527.00
IUUC-Mpu-066029 Mustela putorius furo 94.44 6.00e-123 432.00
IUUC-Mlu-067741 Myotis lucifugus 99.29 9.00e-151 525.00
IUUC-Nle-069240 Nomascus leucogenys 93.95 1.00e-138 485.00
IUUC-Ont-071248 Oreochromis niloticus 94.31 2.00e-152 531.00
IUUC-Oan-073432 Ornithorhynchus anatinus 97.45 5.00e-122 430.00
IUUC-Olo-080270 Oryza longistaminata 34.41 6.00e-12 65.50
IUUC-Ola-086486 Oryzias latipes 86.36 8.00e-139 486.00
IUUC-Oga-088293 Otolemur garnettii 99.29 3.00e-151 527.00
IUUC-Ptr-090720 Pan troglodytes 100.00 1.00e-151 528.00
IUUC-Pan-091732 Papio anubis 100.00 1.00e-151 528.00
IUUC-Psi-093627 Pelodiscus sinensis 96.09 1.00e-142 498.00
IUUC-Pfo-097105 Poecilia formosa 93.24 6.00e-152 529.00
IUUC-Pab-098054 Pongo abelii 100.00 1.00e-151 528.00
IUUC-Pca-100775 Procavia capensis 97.93 1.00e-89 322.00
IUUC-Pva-102658 Pteropus vampyrus 98.93 4.00e-150 523.00
IUUC-Rno-105303 Rattus norvegicus 99.29 3.00e-151 527.00
IUUC-Sha-106536 Sarcophilus harrisii 97.51 2.00e-150 524.00
IUUC-Tgu-116858 Taeniopygia guttata 98.96 5.00e-114 402.00
IUUC-Tru-118264 Takifugu rubripes 77.08 4.00e-139 487.00
IUUC-Tni-120350 Tetraodon nigroviridis 93.24 4.00e-151 526.00
IUUC-Ttr-129236 Tursiops truncatus 99.29 9.00e-153 532.00
Created Date 25-Jun-2017

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