iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053788

UUCD1 version

UUC-LoA-01073

Ensembl Protein ID

ENSLAFP00000010757.4

UniProt Accession

G3TA90; G3TA90_LOXAF

Protein Name

Uncharacterized protein

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000012851.4	ENSLAFT00000026844.1	ENSLAFP00000023539.1
ENSLAFG00000012851.4	ENSLAFT00000012862.4	ENSLAFP00000010757.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.80e-115	384.4	539	1257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 539  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 625
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c +vs +++p
   Q: 626  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCTKVSITFDP 710
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 711  FLYLPVPLPQKQKVLPIfyfarephskpikflvsvskenssasevldslsqsvhvkpenlrlaeviknrfhrmflpshsldtvspsd 797
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 798  mllcfellspelakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 884
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 885  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrtalesqgpgctsllstssleagdserdpiqppelqlvtsvaegdtgvprv 971
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 972  wsapdrgpmpstsgvssemlatgpveigslptgervsrpeaaipgyqhpseamsahtpqffiykidasnreqrledkgrcgllelgd 1058
           *************************************************************************************** PP
   S: 186  ...........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPev 229
                                                      +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+v
   Q: 1059 dcslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNV 1145
           *************************************************************************************** PP
   S: 230  LilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wl 307
           Li++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W 
   Q: 1146 LIVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWR 1229
           *************8886.**********9**********99888..9**************************544445566777** PP
   S: 308  lfdDskVtevkeeevleetgstaYvlfYkrr 338
           lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1230 LFDDSTVTTVDESQVVT---RYAYVLFYRRR 1257
           *****************...********996 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSGGASAMGP RRGPPGLEEA TSKKKQKDRA NQESKDGDPR RESVSSPREE QTKEELLLDW 60
KQNADEVIVK LRVGAGALRL EEVDAAFTDT DCVVRLPDGR QWGGVFYAEI ESSCTKVQAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAATTTGGC CACAAAGAGT TGCCAAGATA GCTGGGCCAG GAAGGAAGCG CCGCAGCCCT 60
GACCCAGACG CCGTTGCCGA CCCTGGGGCA CTCTGGCTGT CAACCAAGCG GCTCAAGATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	90.85	0.00e+00	2282.00
IUUC-Apl-003368	Anas platyrhynchos	66.21	0.00e+00	1711.00
IUUC-Aca-004267	Anolis carolinensis	67.95	0.00e+00	1681.00
IUUC-Ame-010970	Astyanax mexicanus	68.73	0.00e+00	1342.00
IUUC-Bta-012905	Bos taurus	90.18	0.00e+00	2266.00
IUUC-Cel-018257	Caenorhabditis elegans	43.48	2.00e-91	330.00
IUUC-Cja-018789	Callithrix jacchus	87.90	0.00e+00	2346.00
IUUC-Cfa-021004	Canis familiaris	90.19	0.00e+00	2275.00
IUUC-Cpo-021529	Cavia porcellus	90.21	0.00e+00	2339.00
IUUC-Csa-024035	Chlorocebus sabaeus	91.15	0.00e+00	2316.00
IUUC-Cho-025036	Choloepus hoffmanni	86.89	0.00e+00	1259.00
IUUC-Cin-025451	Ciona intestinalis	43.15	9.00e-86	311.00
IUUC-Csv-025931	Ciona savignyi	35.37	8.00e-107	380.00
IUUC-Dre-028556	Danio rerio	68.95	0.00e+00	1326.00
IUUC-Dno-029240	Dasypus novemcinctus	90.41	0.00e+00	2184.00
IUUC-Dor-030495	Dipodomys ordii	94.40	0.00e+00	1245.00
IUUC-Ete-032741	Echinops telfairi	93.40	0.00e+00	1885.00
IUUC-Eca-033661	Equus caballus	93.98	0.00e+00	2395.00
IUUC-Eeu-034648	Erinaceus europaeus	90.43	0.00e+00	809.00
IUUC-Fca-035646	Felis catus	90.51	0.00e+00	2254.00
IUUC-Fal-037094	Ficedula albicollis	68.63	0.00e+00	1811.00
IUUC-Gmo-038869	Gadus morhua	71.45	0.00e+00	847.00
IUUC-Gga-041170	Gallus gallus	65.84	0.00e+00	1752.00
IUUC-Gac-041901	Gasterosteus aculeatus	64.81	0.00e+00	1337.00
IUUC-Ggo-044708	Gorilla gorilla	88.54	0.00e+00	2375.00
IUUC-Hsa-046791	Homo sapiens	93.53	0.00e+00	2034.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	88.70	0.00e+00	2301.00
IUUC-Lch-050456	Latimeria chalumnae	52.50	0.00e+00	1200.00
IUUC-Loc-052861	Lepisosteus oculatus	58.36	0.00e+00	1127.00
IUUC-Mcc-055693	Macaca mulatta	86.94	0.00e+00	2291.00
IUUC-Meu-055921	Macropus eugenii	79.03	0.00e+00	1539.00
IUUC-Mga-059879	Meleagris gallopavo	69.17	0.00e+00	1731.00
IUUC-Mmr-060802	Microcebus murinus	90.63	0.00e+00	2412.00
IUUC-Mdo-061856	Monodelphis domestica	79.05	0.00e+00	1623.00
IUUC-Mmu-063874	Mus musculus	90.76	0.00e+00	2338.00
IUUC-Mpu-066166	Mustela putorius furo	90.12	0.00e+00	2256.00
IUUC-Nle-070161	Nomascus leucogenys	88.33	0.00e+00	2404.00
IUUC-Opr-071015	Ochotona princeps	91.89	0.00e+00	1910.00
IUUC-Ont-072308	Oreochromis niloticus	69.64	0.00e+00	1379.00
IUUC-Oan-072723	Ornithorhynchus anatinus	66.12	0.00e+00	1660.00
IUUC-Ocu-073938	Oryctolagus cuniculus	88.58	0.00e+00	2239.00
IUUC-Ola-086375	Oryzias latipes	70.28	0.00e+00	1343.00
IUUC-Oga-088297	Otolemur garnettii	89.15	0.00e+00	2325.00
IUUC-Oar-089675	Ovis aries	83.37	0.00e+00	2019.00
IUUC-Ptr-091621	Pan troglodytes	93.35	0.00e+00	2032.00
IUUC-Pan-092118	Papio anubis	88.00	0.00e+00	2316.00
IUUC-Pma-094154	Petromyzon marinus	51.78	6.00e-115	407.00
IUUC-Pfo-097246	Poecilia formosa	60.42	0.00e+00	1419.00
IUUC-Pab-098551	Pongo abelii	92.64	0.00e+00	2011.00
IUUC-Pca-100158	Procavia capensis	91.63	0.00e+00	2359.00
IUUC-Pva-103160	Pteropus vampyrus	93.84	0.00e+00	2347.00
IUUC-Rno-105355	Rattus norvegicus	90.31	0.00e+00	2333.00
IUUC-Sha-107057	Sarcophilus harrisii	76.98	0.00e+00	1803.00
IUUC-Sar-113011	Sorex araneus	88.82	0.00e+00	1484.00
IUUC-Ssc-115761	Sus scrofa	89.48	0.00e+00	2288.00
IUUC-Tgu-116956	Taeniopygia guttata	60.72	0.00e+00	836.00
IUUC-Tru-118739	Takifugu rubripes	69.58	0.00e+00	1357.00
IUUC-Tsy-118827	Tarsius syrichta	87.35	0.00e+00	1253.00
IUUC-Tni-119921	Tetraodon nigroviridis	60.98	0.00e+00	1422.00
IUUC-Tbe-128017	Tupaia belangeri	91.67	0.00e+00	1971.00
IUUC-Ttr-128869	Tursiops truncatus	93.32	0.00e+00	2349.00
IUUC-Vpa-130427	Vicugna pacos	94.46	0.00e+00	915.00
IUUC-Xtr-132734	Xenopus tropicalis	61.02	0.00e+00	1545.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence