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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063479
Ensembl Protein ID ENSMUSP00000033468.4
UniProt Accession F6WMJ3; F6WMJ3_MOUSE
Genbank Protein ID ENSMUSP00000033468
Protein Name Rho guanine nucleotide exchange factor 6
Genbank Nucleotide ID AL672106
Gene Name Arhgef6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031133.12 ENSMUST00000033468.10 ENSMUSP00000033468.4
ENSMUSG00000031133.12 ENSMUST00000114735.8 ENSMUSP00000110383.2
ENSMUSG00000031133.12 ENSMUST00000175900.1 ENSMUSP00000135475.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 6.80e-14 52.7 187 241
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++ ++++ +n+deL+  kGd+++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 187  IVKARFNFKQTNEDELSVCKGDIIYVT--RVEEGGWWEG--TLNGRTGWFPSNYVREIK 241
           68999*********************7..999*******..8**************996 PP
   
Organism Mus musculus
Protein Sequence
(Fasta)
MQSRMWLSLH SCPESCSERP RASVMNPEER LVTWLISLGV LESPKKTVCD PEEFLKSSLK 60
NGVVLCKLIN RLLPGSVEKY CLEPQTEADC IDNINDFLKG CATLQVEVFE PDDLYSGANF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063479|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGTTTGTC CATTCCTTAT CATTCCTTTC CATATCTTTA GGTATGATCT CTGTGGTTTA 60
GAAATCCCAC GTTCCTCTGT TGTCAGAGAA AAGTTGCCTT AAACCTTTGC CCCGCAAGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063479|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain
IPR003096--SM22_calponin
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
PR00888--SM22CALPONIN
SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3
Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction
KEGG mmu:73341
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001631 Ailuropoda melanoleuca 83.57 0.00e+00 1112.00
IUUC-Apl-003960 Anas platyrhynchos 73.71 0.00e+00 1097.00
IUUC-Aca-004988 Anolis carolinensis 68.89 0.00e+00 1019.00
IUUC-Aly-005591 Arabidopsis lyrata 38.71 8.00e-09 54.70
IUUC-Ame-011546 Astyanax mexicanus 63.21 0.00e+00 935.00
IUUC-Bta-013527 Bos taurus 90.84 0.00e+00 1343.00
IUUC-Cja-018935 Callithrix jacchus 90.97 0.00e+00 1327.00
IUUC-Cfa-021269 Canis familiaris 90.06 0.00e+00 1318.00
IUUC-Cpo-021620 Cavia porcellus 86.54 0.00e+00 1264.00
IUUC-Csa-023415 Chlorocebus sabaeus 91.10 0.00e+00 1330.00
IUUC-Dre-028580 Danio rerio 62.91 0.00e+00 956.00
IUUC-Dno-029201 Dasypus novemcinctus 84.45 0.00e+00 1307.00
IUUC-Dor-030868 Dipodomys ordii 73.81 0.00e+00 999.00
IUUC-Eca-033500 Equus caballus 91.61 0.00e+00 1327.00
IUUC-Eeu-035269 Erinaceus europaeus 80.17 2.00e-158 552.00
IUUC-Fca-035683 Felis catus 89.55 0.00e+00 1296.00
IUUC-Fal-037611 Ficedula albicollis 73.84 0.00e+00 1098.00
IUUC-Gmo-038980 Gadus morhua 60.44 0.00e+00 903.00
IUUC-Gga-040940 Gallus gallus 72.98 0.00e+00 1102.00
IUUC-Gac-042203 Gasterosteus aculeatus 60.98 0.00e+00 933.00
IUUC-Ggo-044755 Gorilla gorilla 91.48 0.00e+00 1336.00
IUUC-Hsa-046210 Homo sapiens 91.23 0.00e+00 1334.00
IUUC-Lch-049517 Latimeria chalumnae 68.72 0.00e+00 1017.00
IUUC-Loc-052393 Lepisosteus oculatus 63.81 0.00e+00 1020.00
IUUC-Laf-054196 Loxodonta africana 88.92 0.00e+00 1323.00
IUUC-Mcc-055716 Macaca mulatta 91.10 0.00e+00 1330.00
IUUC-Meu-056285 Macropus eugenii 72.08 0.00e+00 664.00
IUUC-Mtr-058576 Medicago truncatula 44.44 6.00e-11 61.60
IUUC-Mga-060029 Meleagris gallopavo 73.71 0.00e+00 1102.00
IUUC-Mmr-060803 Microcebus murinus 91.23 0.00e+00 1334.00
IUUC-Mdo-062654 Monodelphis domestica 78.69 0.00e+00 1185.00
IUUC-Mpu-066065 Mustela putorius furo 89.81 0.00e+00 1298.00
IUUC-Mlu-068222 Myotis lucifugus 89.43 0.00e+00 1286.00
IUUC-Nle-069379 Nomascus leucogenys 91.61 0.00e+00 1338.00
IUUC-Opr-070687 Ochotona princeps 71.82 0.00e+00 806.00
IUUC-Ont-072240 Oreochromis niloticus 57.89 0.00e+00 897.00
IUUC-Oan-073067 Ornithorhynchus anatinus 78.58 0.00e+00 1191.00
IUUC-Ocu-074852 Oryctolagus cuniculus 90.32 0.00e+00 1312.00
IUUC-Oga-089048 Otolemur garnettii 83.88 0.00e+00 1139.00
IUUC-Oar-089339 Ovis aries 89.61 0.00e+00 1359.00
IUUC-Pan-092666 Papio anubis 88.67 0.00e+00 1279.00
IUUC-Psi-093116 Pelodiscus sinensis 73.84 0.00e+00 1123.00
IUUC-Pfo-097394 Poecilia formosa 60.78 0.00e+00 926.00
IUUC-Pab-098567 Pongo abelii 91.35 0.00e+00 1336.00
IUUC-Pca-100997 Procavia capensis 77.04 0.00e+00 1060.00
IUUC-Pva-102500 Pteropus vampyrus 88.90 0.00e+00 1270.00
IUUC-Rno-104974 Rattus norvegicus 97.24 0.00e+00 1429.00
IUUC-Sar-113420 Sorex araneus 85.81 0.00e+00 1223.00
IUUC-Ssc-115679 Sus scrofa 90.74 0.00e+00 1165.00
IUUC-Tgu-117069 Taeniopygia guttata 72.91 0.00e+00 1085.00
IUUC-Tru-118488 Takifugu rubripes 56.21 0.00e+00 826.00
IUUC-Tsy-119243 Tarsius syrichta 83.15 0.00e+00 909.00
IUUC-Tni-120584 Tetraodon nigroviridis 59.85 0.00e+00 905.00
IUUC-Tbe-127994 Tupaia belangeri 75.61 0.00e+00 1078.00
IUUC-Ttr-128839 Tursiops truncatus 89.68 0.00e+00 1283.00
IUUC-Vpa-130144 Vicugna pacos 82.46 0.00e+00 1136.00
IUUC-Xtr-132624 Xenopus tropicalis 68.96 0.00e+00 1042.00
Created Date 25-Jun-2017

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