iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069222

Ensembl Protein ID

ENSNLEP00000011876.2

UniProt Accession

G1RF76; G1RF76_NOMLE

Genbank Protein ID

ENSNLEP00000011876

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADFV01077120

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000009721.2	ENSNLET00000012458.2	ENSNLEP00000011876.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.60e-16	58.9	60	115

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +lydyea + ++L+++kGd++ v+   e++++W+k+ + ++ k+G +P+n+v++++
   Q: 60   IVVALYDYEAIHHEDLSFQKGDQMVVL---EESGEWWKARSLATRKEGYIPSNYVARVD 115
           689************************...99*************************97 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MGCMKSKFLQ VRGNTFSKTE TSANPHCPVY VPDPTSTIKP GPNSNNSNTP GIREGSEDII 60
VVALYDYEAI HHEDLSFQKG DQMVVLEESG EWWKARSLAT RKEGYIPSNY VARVDSLETE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGGCTAAG GCGCCCAGAT GGCCTGCGGG CGCCACCACG TCCCTGGTCC CAGCTCCGGA 60
GCACATCAGA GGCTTAGAGG CGAGTGGGAA GGGACTCAGT GCAGGGCGAG AAACGCCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

KEGG

nle:100587780

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	91.11	0.00e+00	953.00
IUUC-Apl-003285	Anas platyrhynchos	78.59	0.00e+00	815.00
IUUC-Aca-004724	Anolis carolinensis	78.35	0.00e+00	792.00
IUUC-Aly-005712	Arabidopsis lyrata	31.09	1.00e-19	92.00
IUUC-Ame-011954	Astyanax mexicanus	76.09	0.00e+00	772.00
IUUC-Bta-013060	Bos taurus	91.27	0.00e+00	962.00
IUUC-Cja-019817	Callithrix jacchus	95.45	0.00e+00	978.00
IUUC-Cfa-020511	Canis familiaris	91.67	0.00e+00	966.00
IUUC-Cpo-022538	Cavia porcellus	90.50	0.00e+00	956.00
IUUC-Csa-024143	Chlorocebus sabaeus	98.02	0.00e+00	1032.00
IUUC-Dre-028157	Danio rerio	77.08	0.00e+00	800.00
IUUC-Dno-029761	Dasypus novemcinctus	88.91	0.00e+00	933.00
IUUC-Dor-030892	Dipodomys ordii	67.86	0.00e+00	687.00
IUUC-Eca-034090	Equus caballus	88.10	0.00e+00	922.00
IUUC-Eeu-035004	Erinaceus europaeus	58.56	2.00e-145	508.00
IUUC-Fca-035937	Felis catus	88.89	0.00e+00	904.00
IUUC-Fal-036624	Ficedula albicollis	78.00	0.00e+00	808.00
IUUC-Gmo-039009	Gadus morhua	73.41	0.00e+00	764.00
IUUC-Gga-040296	Gallus gallus	75.10	0.00e+00	785.00
IUUC-Gac-042362	Gasterosteus aculeatus	74.95	0.00e+00	784.00
IUUC-Ggo-044570	Gorilla gorilla	98.02	0.00e+00	1022.00
IUUC-Hsa-046378	Homo sapiens	98.02	0.00e+00	1036.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	90.10	0.00e+00	944.00
IUUC-Loc-052904	Lepisosteus oculatus	79.13	0.00e+00	828.00
IUUC-Laf-053654	Loxodonta africana	89.48	0.00e+00	936.00
IUUC-Mcc-055317	Macaca mulatta	98.41	0.00e+00	1040.00
IUUC-Meu-056879	Macropus eugenii	70.80	0.00e+00	680.00
IUUC-Mga-060194	Meleagris gallopavo	80.85	0.00e+00	768.00
IUUC-Mmr-061510	Microcebus murinus	89.90	0.00e+00	944.00
IUUC-Mdo-062035	Monodelphis domestica	83.56	0.00e+00	878.00
IUUC-Mmu-064037	Mus musculus	90.08	0.00e+00	951.00
IUUC-Mpu-066874	Mustela putorius furo	91.09	0.00e+00	958.00
IUUC-Mlu-068202	Myotis lucifugus	88.49	0.00e+00	909.00
IUUC-Opr-070705	Ochotona princeps	87.33	0.00e+00	927.00
IUUC-Ont-072347	Oreochromis niloticus	83.18	0.00e+00	772.00
IUUC-Ocu-074490	Oryctolagus cuniculus	89.68	0.00e+00	935.00
IUUC-Oni-082350	Oryza nivara	29.47	4.00e-22	100.00
IUUC-Opu-083900	Oryza punctata	29.68	2.00e-22	101.00
IUUC-Ola-086521	Oryzias latipes	82.06	0.00e+00	782.00
IUUC-Oga-088153	Otolemur garnettii	91.49	0.00e+00	957.00
IUUC-Oar-090184	Ovis aries	90.93	0.00e+00	959.00
IUUC-Ptr-090505	Pan troglodytes	94.26	0.00e+00	970.00
IUUC-Pan-092260	Papio anubis	98.21	0.00e+00	1040.00
IUUC-Pma-094311	Petromyzon marinus	72.98	0.00e+00	738.00
IUUC-Pfo-096566	Poecilia formosa	76.33	0.00e+00	800.00
IUUC-Pab-097908	Pongo abelii	77.82	0.00e+00	768.00
IUUC-Pva-103021	Pteropus vampyrus	91.29	0.00e+00	956.00
IUUC-Rno-105309	Rattus norvegicus	90.08	0.00e+00	950.00
IUUC-Sha-107099	Sarcophilus harrisii	82.97	0.00e+00	877.00
IUUC-Ssc-115624	Sus scrofa	65.62	0.00e+00	695.00
IUUC-Tgu-116912	Taeniopygia guttata	78.15	0.00e+00	801.00
IUUC-Tru-118449	Takifugu rubripes	82.02	0.00e+00	766.00
IUUC-Tae-123837	Triticum aestivum	28.16	1.00e-22	101.00
IUUC-Tbe-128144	Tupaia belangeri	86.67	0.00e+00	804.00
IUUC-Vvi-131372	Vitis vinifera	29.12	3.00e-21	97.10
IUUC-Xtr-132224	Xenopus tropicalis	71.14	0.00e+00	694.00
IUUC-Xma-133902	Xiphophorus maculatus	76.04	0.00e+00	795.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence