iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028005

Ensembl Protein ID

ENSDARP00000130859.1

UniProt Accession

Q1RLY5; Q1RLY5_DANRE

Genbank Protein ID

AAI15231.1; AAI62357.1; AAI62378.1

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

CR392364; BC162357; BC162378

Gene Name

lck; zgc:136695

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000102525.1	ENSDART00000165282.1	ENSDARP00000130859.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.70e-16	58.4	56	113

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v ++y y+++++d+L ++kG++++++  ++ d +W ++++  +g+rG +P+nFv+kl+
   Q: 56   NLVVAIYKYDPAHSDDLGFEKGEKMKIL--DCDDPEWYMAESLFTGQRGYIPKNFVAKLN 113
           7899************************..***************************997 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MGNCGSFDPD DEFSYHPDEW CDQCNCPKPP VSQNFDPLIP YPSQYTPPPS SPLPENLVVA 60
IYKYDPAHSD DLGFEKGEKM KILDCDDPEW YMAESLFTGQ RGYIPKNFVA KLNSMETEPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCAAGTGC TTCTTTTAAG GTGGGAAGTA AAACTGTGAT GTGACGTACA CATTTTTACA 60
ATTTGGCAGC ACATGTCTTT GAAACACGCC GAAGAAGATC TCGATGGTTT GTCTGTAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0030217--P:T cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	65.56	0.00e+00	719.00
IUUC-Ame-010831	Astyanax mexicanus	84.28	0.00e+00	782.00
IUUC-Bta-013264	Bos taurus	69.20	0.00e+00	739.00
IUUC-Cfa-021161	Canis familiaris	65.38	0.00e+00	718.00
IUUC-Cpo-022492	Cavia porcellus	69.20	0.00e+00	737.00
IUUC-Dno-029365	Dasypus novemcinctus	66.28	0.00e+00	691.00
IUUC-Dor-030892	Dipodomys ordii	68.74	0.00e+00	714.00
IUUC-Eca-033325	Equus caballus	67.32	0.00e+00	705.00
IUUC-Eeu-035004	Erinaceus europaeus	60.45	7.00e-155	540.00
IUUC-Fca-035908	Felis catus	69.40	0.00e+00	736.00
IUUC-Gmo-038984	Gadus morhua	72.47	0.00e+00	775.00
IUUC-Gga-040997	Gallus gallus	69.73	0.00e+00	740.00
IUUC-Gac-041854	Gasterosteus aculeatus	76.80	0.00e+00	808.00
IUUC-Ggo-045238	Gorilla gorilla	65.56	0.00e+00	723.00
IUUC-Hsa-047039	Homo sapiens	69.40	0.00e+00	738.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	69.40	0.00e+00	738.00
IUUC-Lch-049568	Latimeria chalumnae	70.96	0.00e+00	759.00
IUUC-Loc-052222	Lepisosteus oculatus	73.08	0.00e+00	732.00
IUUC-Laf-054499	Loxodonta africana	65.38	0.00e+00	716.00
IUUC-Meu-056879	Macropus eugenii	67.31	0.00e+00	708.00
IUUC-Mga-059971	Meleagris gallopavo	71.14	0.00e+00	733.00
IUUC-Mmr-060740	Microcebus murinus	69.40	0.00e+00	738.00
IUUC-Mdo-062192	Monodelphis domestica	69.40	0.00e+00	733.00
IUUC-Mmu-064241	Mus musculus	68.81	0.00e+00	736.00
IUUC-Mpu-066595	Mustela putorius furo	70.79	0.00e+00	730.00
IUUC-Mlu-067069	Myotis lucifugus	69.26	0.00e+00	737.00
IUUC-Opr-070472	Ochotona princeps	65.99	0.00e+00	719.00
IUUC-Ont-071711	Oreochromis niloticus	77.80	0.00e+00	795.00
IUUC-Ocu-074221	Oryctolagus cuniculus	68.68	0.00e+00	726.00
IUUC-Ola-087000	Oryzias latipes	72.51	0.00e+00	767.00
IUUC-Oga-088225	Otolemur garnettii	68.81	0.00e+00	731.00
IUUC-Oar-090244	Ovis aries	61.10	0.00e+00	684.00
IUUC-Pan-091804	Papio anubis	69.76	0.00e+00	739.00
IUUC-Pfo-096542	Poecilia formosa	76.03	0.00e+00	812.00
IUUC-Pab-098168	Pongo abelii	73.67	0.00e+00	739.00
IUUC-Rno-105542	Rattus norvegicus	68.62	0.00e+00	735.00
IUUC-Sha-107524	Sarcophilus harrisii	71.20	0.00e+00	729.00
IUUC-Stu-112331	Solanum tuberosum	29.60	2.00e-22	101.00
IUUC-Sar-113235	Sorex araneus	64.21	2.00e-175	608.00
IUUC-Ssc-115624	Sus scrofa	68.81	0.00e+00	728.00
IUUC-Tru-118559	Takifugu rubripes	72.89	0.00e+00	777.00
IUUC-Tni-119928	Tetraodon nigroviridis	66.01	0.00e+00	669.00
IUUC-Tca-121341	Theobroma cacao	35.78	2.00e-21	98.20
IUUC-Ttr-129002	Tursiops truncatus	62.62	0.00e+00	676.00
IUUC-Xtr-132224	Xenopus tropicalis	68.18	0.00e+00	714.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence