iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045238

Ensembl Protein ID

ENSGGOP00000002526.2

UniProt Accession

G3QJD4; G3QJD4_GORGO

Protein Name

Tyrosine-protein kinase

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000002562.2	ENSGGOT00000002579.2	ENSGGOP00000002526.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.70e-19	68.8	62	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++ye+++d++L ++kG++++++   eq+++W+k+++ ++g++G++P nFv+k++
   Q: 62   QDNLVIALHSYEPSHDGDLGFEKGEQLRIL---EQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
           6899**************************...**************************987 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTCAGGGT GGGACGTGGG CGCGGGGAGA CAGGTGGTGG CTACGACGGT GAAGGGAGCT 60
GAGACTGTCC AGGCAGCCAG GTTAGGCCAG GAGGACCATG TGAATGGAGC CAGAGGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	96.29	0.00e+00	1075.00
IUUC-Apl-004134	Anas platyrhynchos	75.37	0.00e+00	717.00
IUUC-Bta-013264	Bos taurus	90.91	0.00e+00	1012.00
IUUC-Cja-019574	Callithrix jacchus	87.88	0.00e+00	697.00
IUUC-Cfa-021161	Canis familiaris	95.18	0.00e+00	1039.00
IUUC-Cpo-022492	Cavia porcellus	90.54	0.00e+00	1003.00
IUUC-Csa-023270	Chlorocebus sabaeus	76.01	0.00e+00	806.00
IUUC-Dre-028005	Danio rerio	70.29	0.00e+00	702.00
IUUC-Dno-029365	Dasypus novemcinctus	89.24	0.00e+00	976.00
IUUC-Dor-030892	Dipodomys ordii	94.05	0.00e+00	973.00
IUUC-Eca-033325	Equus caballus	90.19	0.00e+00	989.00
IUUC-Eeu-035004	Erinaceus europaeus	93.45	0.00e+00	823.00
IUUC-Fca-035908	Felis catus	92.39	0.00e+00	1026.00
IUUC-Fal-036804	Ficedula albicollis	67.27	0.00e+00	718.00
IUUC-Gmo-038984	Gadus morhua	60.85	0.00e+00	681.00
IUUC-Gga-040997	Gallus gallus	78.11	0.00e+00	887.00
IUUC-Gac-041854	Gasterosteus aculeatus	65.37	0.00e+00	719.00
IUUC-Hsa-047039	Homo sapiens	94.43	0.00e+00	1049.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	92.76	0.00e+00	1029.00
IUUC-Lch-049568	Latimeria chalumnae	73.06	0.00e+00	832.00
IUUC-Loc-052222	Lepisosteus oculatus	63.67	0.00e+00	662.00
IUUC-Laf-054499	Loxodonta africana	93.32	0.00e+00	1014.00
IUUC-Mcc-054872	Macaca mulatta	74.54	0.00e+00	852.00
IUUC-Meu-056879	Macropus eugenii	88.13	0.00e+00	987.00
IUUC-Mga-059971	Meleagris gallopavo	77.55	0.00e+00	877.00
IUUC-Mmr-060740	Microcebus murinus	91.84	0.00e+00	1021.00
IUUC-Mdo-062192	Monodelphis domestica	87.76	0.00e+00	980.00
IUUC-Mmu-064241	Mus musculus	91.47	0.00e+00	1016.00
IUUC-Mpu-066595	Mustela putorius furo	91.84	0.00e+00	1017.00
IUUC-Mlu-067069	Myotis lucifugus	90.56	0.00e+00	1006.00
IUUC-Opr-070472	Ochotona princeps	94.99	0.00e+00	1064.00
IUUC-Ont-071711	Oreochromis niloticus	64.63	0.00e+00	688.00
IUUC-Ocu-074221	Oryctolagus cuniculus	91.48	0.00e+00	1014.00
IUUC-Ola-087000	Oryzias latipes	65.24	0.00e+00	715.00
IUUC-Oga-088225	Otolemur garnettii	91.47	0.00e+00	1016.00
IUUC-Oar-090244	Ovis aries	80.81	0.00e+00	950.00
IUUC-Ptr-090751	Pan troglodytes	91.84	0.00e+00	716.00
IUUC-Pan-091804	Papio anubis	93.51	0.00e+00	1035.00
IUUC-Psi-093252	Pelodiscus sinensis	70.96	0.00e+00	783.00
IUUC-Pfo-096542	Poecilia formosa	63.99	0.00e+00	717.00
IUUC-Pab-098168	Pongo abelii	93.04	0.00e+00	983.00
IUUC-Pca-100547	Procavia capensis	96.88	0.00e+00	649.00
IUUC-Rno-105542	Rattus norvegicus	91.28	0.00e+00	1016.00
IUUC-Sha-107524	Sarcophilus harrisii	86.83	0.00e+00	975.00
IUUC-Sar-113235	Sorex araneus	92.58	0.00e+00	898.00
IUUC-Ssc-115624	Sus scrofa	91.09	0.00e+00	1013.00
IUUC-Tru-118559	Takifugu rubripes	63.74	0.00e+00	711.00
IUUC-Ttr-129002	Tursiops truncatus	92.21	0.00e+00	1022.00
IUUC-Xtr-132224	Xenopus tropicalis	71.80	0.00e+00	819.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence