iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074686

Ensembl Protein ID

ENSOCUP00000010712.2

UniProt Accession

G1T3B6; G1T3B6_RABIT

Genbank Protein ID

ENSOCUP00000010712

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02015478

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000012449.3	ENSOCUT00000012445.3	ENSOCUP00000010712.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-12	47.0	436	486

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++lydy+++ +deL++   d+++ i  e  degW++g    +g+ GlfP+n+v+ 
   Q: 436  IALYDYQGEGSDELSFDPDDIITDI--EMVDEGWWRG--RCHGYFGLFPANYVKL 486
           79**********************9..9*********..8*************85 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGHAE HINIHQLRSK 60
VSEEHDVLKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAGATGGA ACTGACCAGC TATTTAGGTC ACAAGTGCTG TTCTCCAGCA TTGTCTGATG 60
GGTTTCTGAG TGAAGCTTTC TCTGACTGCT TGATAAAGTC TGAAAGTTGG AGCAACATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

KEGG

ocu:100340933

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	80.28	0.00e+00	664.00
IUUC-Apl-003745	Anas platyrhynchos	57.71	2.00e-85	309.00
IUUC-Aca-004438	Anolis carolinensis	64.84	2.00e-81	296.00
IUUC-Ame-011504	Astyanax mexicanus	44.21	9.00e-98	350.00
IUUC-Bta-012591	Bos taurus	89.97	1.00e-163	569.00
IUUC-Cja-019982	Callithrix jacchus	88.95	7.00e-162	563.00
IUUC-Cfa-020262	Canis familiaris	96.00	4.00e-27	115.00
IUUC-Cpo-021362	Cavia porcellus	78.23	0.00e+00	629.00
IUUC-Csa-023911	Chlorocebus sabaeus	91.12	1.00e-167	582.00
IUUC-Cin-025677	Ciona intestinalis	54.63	5.00e-65	241.00
IUUC-Csv-026140	Ciona savignyi	59.68	7.00e-64	238.00
IUUC-Dre-028127	Danio rerio	70.89	2.00e-93	336.00
IUUC-Dno-029332	Dasypus novemcinctus	64.32	7.00e-91	327.00
IUUC-Dor-030437	Dipodomys ordii	73.58	8.00e-170	589.00
IUUC-Dme-031931	Drosophila melanogaster	47.62	1.00e-71	264.00
IUUC-Ete-033160	Echinops telfairi	71.24	2.00e-138	485.00
IUUC-Eca-033269	Equus caballus	81.06	0.00e+00	678.00
IUUC-Eeu-035032	Erinaceus europaeus	69.13	2.00e-113	402.00
IUUC-Fca-035999	Felis catus	80.04	0.00e+00	699.00
IUUC-Fal-037107	Ficedula albicollis	50.74	4.00e-120	424.00
IUUC-Gmo-038507	Gadus morhua	64.71	4.00e-16	79.30
IUUC-Gga-040335	Gallus gallus	68.20	3.00e-107	382.00
IUUC-Gac-042253	Gasterosteus aculeatus	68.54	3.00e-87	315.00
IUUC-Ggo-044505	Gorilla gorilla	82.45	0.00e+00	665.00
IUUC-Hsa-046728	Homo sapiens	90.26	2.00e-165	575.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	65.36	2.00e-156	545.00
IUUC-Lch-050221	Latimeria chalumnae	78.70	7.00e-101	361.00
IUUC-Loc-052855	Lepisosteus oculatus	67.45	4.00e-87	315.00
IUUC-Laf-054202	Loxodonta africana	87.83	5.00e-150	523.00
IUUC-Mcc-055824	Macaca mulatta	91.12	5.00e-168	583.00
IUUC-Mga-059791	Meleagris gallopavo	56.92	1.00e-84	307.00
IUUC-Mmr-061281	Microcebus murinus	73.98	1.00e-155	542.00
IUUC-Mdo-062515	Monodelphis domestica	67.28	2.00e-140	492.00
IUUC-Mmu-064341	Mus musculus	83.50	0.00e+00	662.00
IUUC-Mpu-066565	Mustela putorius furo	89.33	5.00e-154	537.00
IUUC-Mlu-066942	Myotis lucifugus	78.88	5.00e-178	617.00
IUUC-Nle-069436	Nomascus leucogenys	91.12	9.00e-168	583.00
IUUC-Opr-070288	Ochotona princeps	79.55	3.00e-163	568.00
IUUC-Ont-071712	Oreochromis niloticus	74.18	7.00e-92	331.00
IUUC-Oan-073528	Ornithorhynchus anatinus	36.87	1.00e-65	243.00
IUUC-Ola-086894	Oryzias latipes	59.44	5.00e-94	338.00
IUUC-Oga-088585	Otolemur garnettii	73.55	3.00e-172	597.00
IUUC-Oar-089686	Ovis aries	80.49	0.00e+00	655.00
IUUC-Ptr-090461	Pan troglodytes	91.12	4.00e-167	580.00
IUUC-Pan-091887	Papio anubis	91.12	6.00e-168	583.00
IUUC-Psi-093785	Pelodiscus sinensis	61.54	6.00e-115	407.00
IUUC-Pma-094161	Petromyzon marinus	62.58	2.00e-55	210.00
IUUC-Pfo-097391	Poecilia formosa	68.08	3.00e-88	318.00
IUUC-Pab-098222	Pongo abelii	90.83	2.00e-166	578.00
IUUC-Pca-100668	Procavia capensis	86.38	6.00e-154	536.00
IUUC-Pva-102767	Pteropus vampyrus	68.38	9.00e-144	503.00
IUUC-Rno-106001	Rattus norvegicus	83.16	0.00e+00	664.00
IUUC-Sha-106912	Sarcophilus harrisii	93.90	7.00e-118	417.00
IUUC-Sar-113338	Sorex araneus	73.04	2.00e-155	541.00
IUUC-Ssc-116027	Sus scrofa	82.59	0.00e+00	683.00
IUUC-Tgu-117472	Taeniopygia guttata	58.32	7.00e-148	516.00
IUUC-Tru-118718	Takifugu rubripes	64.62	9.00e-85	307.00
IUUC-Tni-119931	Tetraodon nigroviridis	57.60	2.00e-93	336.00
IUUC-Xtr-131797	Xenopus tropicalis	68.54	4.00e-82	298.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence