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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105788
UUCD1 version UUC-RaN-00823
Ensembl Protein ID ENSRNOP00000008873.4
UniProt Accession Q56AP7; A1L110; Q499S7; CRBN_RAT
Genbank Protein ID AAX73356.1; AAH99779.1; AAI27456.1
Protein Name Protein cereblon
Genbank Nucleotide ID AY973953; BC099779; BC127455
Gene Name Crbn
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000006534.5 ENSRNOT00000008873.4 ENSRNOP00000008873.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 93.48 0.00e+00 854.00 IUUC-Hsa-046888
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
 Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
Protein Sequence
(Fasta)
MAGEGDHQDA AHNMGNHLPL LPADSEDEDD EIEMEVEDQD SKEARKPNII NFDTSLPTSH 60
TYLGADMEEF HGRTLHDDDS CQVIPVLPEV MMILIPGQTL PLQLSHPQEV SMVRNLIQKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105788|E3,E3 activity/Other|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGGTAAACA GACATGGCCG GCGAGGGAGA TCACCAGGAC GCTGCGCACA ACATGGGAAA 60
CCACCTGCCG CTTCTGCCTG GTAACCTCGG GGACGGGCGC CTAGTCATGG GTGGAGACCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105788|E3,E3 activity/Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR034750--CULT
IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR004910--Yippee/Mis18/Cereblon
PROSITE

PS51788--CULT
PS51787--LON_N
Pfam

PF02190--LON_substr_bdg
PF03226--Yippee-Mis18
SMART

SM00464--LON
Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0034766--P:negative regulation of ion transmembrane transport
GO:0032463--P:negative regulation of protein homooligomerization
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG rno:297498
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000549 Aegilops tauschii 30.46 9.00e-24 104.00
IUUC-Aml-002159 Ailuropoda melanoleuca 93.50 0.00e+00 858.00
IUUC-Atr-002820 Amborella trichopoda 38.80 1.00e-37 150.00
IUUC-Apl-003508 Anas platyrhynchos 81.66 0.00e+00 741.00
IUUC-Aca-004675 Anolis carolinensis 82.37 0.00e+00 726.00
IUUC-Aly-005404 Arabidopsis lyrata 36.84 7.00e-38 151.00
IUUC-Ath-006819 Arabidopsis thaliana 36.32 2.00e-37 150.00
IUUC-Ani-009423 Aspergillus nidulans 36.84 1.20e-01 31.60
IUUC-Ame-010773 Astyanax mexicanus 67.33 2.00e-173 601.00
IUUC-Bta-012711 Bos taurus 92.13 0.00e+00 845.00
IUUC-Bdi-014416 Brachypodium distachyon 35.53 1.00e-37 150.00
IUUC-Bol-015668 Brassica oleracea 37.24 3.00e-39 156.00
IUUC-Bra-016836 Brassica rapa 37.24 3.00e-39 156.00
IUUC-Cja-019624 Callithrix jacchus 93.48 0.00e+00 858.00
IUUC-Cpo-022319 Cavia porcellus 91.24 0.00e+00 842.00
IUUC-Csa-023791 Chlorocebus sabaeus 93.26 0.00e+00 853.00
IUUC-Cho-024850 Choloepus hoffmanni 95.95 0.00e+00 699.00
IUUC-Csv-025832 Ciona savignyi 43.81 1.00e-88 320.00
IUUC-Cgl-026484 Colletotrichum gloeosporioides 31.82 5.20e-01 29.30
IUUC-Dre-028071 Danio rerio 68.74 3.00e-177 614.00
IUUC-Dno-029431 Dasypus novemcinctus 93.26 0.00e+00 859.00
IUUC-Dor-030571 Dipodomys ordii 78.65 0.00e+00 681.00
IUUC-Dme-031920 Drosophila melanogaster 28.50 7.00e-37 148.00
IUUC-Eca-033462 Equus caballus 93.26 0.00e+00 855.00
IUUC-Fca-036279 Felis catus 92.50 0.00e+00 837.00
IUUC-Fal-037498 Ficedula albicollis 76.39 0.00e+00 709.00
IUUC-Fox-037856 Fusarium oxysporum 42.86 2.40e-01 30.40
IUUC-Gmo-038734 Gadus morhua 69.98 5.00e-179 620.00
IUUC-Gga-040615 Gallus gallus 82.33 0.00e+00 746.00
IUUC-Gac-041426 Gasterosteus aculeatus 70.81 0.00e+00 633.00
IUUC-Gma-043891 Glycine max 40.45 5.00e-39 155.00
IUUC-Ggo-045108 Gorilla gorilla 93.03 0.00e+00 850.00
IUUC-Hsa-046888 Homo sapiens 93.48 0.00e+00 853.00
IUUC-Itr-047937 Ictidomys tridecemlineatus 96.05 0.00e+00 823.00
IUUC-Lch-050189 Latimeria chalumnae 75.37 4.00e-176 610.00
IUUC-Lpe-050808 Leersia perrieri 39.90 2.00e-43 170.00
IUUC-Loc-051762 Lepisosteus oculatus 74.43 0.00e+00 654.00
IUUC-Laf-053882 Loxodonta africana 92.81 0.00e+00 845.00
IUUC-Mcc-054883 Macaca mulatta 93.26 0.00e+00 853.00
IUUC-Mtr-058216 Medicago truncatula 40.45 1.00e-39 157.00
IUUC-Mdo-062260 Monodelphis domestica 82.77 0.00e+00 758.00
IUUC-Mmu-063438 Mus musculus 98.88 0.00e+00 882.00
IUUC-Mac-064610 Musa acuminata 45.41 4.00e-46 179.00
IUUC-Mpu-066362 Mustela putorius furo 92.81 0.00e+00 855.00
IUUC-Nle-069908 Nomascus leucogenys 93.26 0.00e+00 852.00
IUUC-Ont-072223 Oreochromis niloticus 71.89 0.00e+00 641.00
IUUC-Ocu-074151 Oryctolagus cuniculus 94.53 0.00e+00 801.00
IUUC-Oba-075882 Oryza barthii 42.02 5.00e-43 169.00
IUUC-Obr-076670 Oryza brachyantha 38.38 1.00e-41 164.00
IUUC-Ogl-077753 Oryza glaberrima 42.02 5.00e-43 169.00
IUUC-Ogu-078786 Oryza glumaepatula 42.02 5.00e-43 169.00
IUUC-Oin-079191 Oryza indica 42.02 5.00e-43 169.00
IUUC-Olo-080357 Oryza longistaminata 42.02 5.00e-43 169.00
IUUC-Ome-081227 Oryza meridionalis 29.76 4.00e-19 89.40
IUUC-Oni-082557 Oryza nivara 42.02 4.00e-43 169.00
IUUC-Opu-083920 Oryza punctata 40.70 2.00e-42 167.00
IUUC-Oru-085227 Oryza rufipogon 42.02 5.00e-43 169.00
IUUC-Ola-087321 Oryzias latipes 71.14 3.00e-173 601.00
IUUC-Oga-088413 Otolemur garnettii 93.48 0.00e+00 865.00
IUUC-Oar-089512 Ovis aries 91.11 0.00e+00 837.00
IUUC-Ptr-090764 Pan troglodytes 93.48 0.00e+00 853.00
IUUC-Pan-091942 Papio anubis 93.26 0.00e+00 853.00
IUUC-Psi-092985 Pelodiscus sinensis 85.09 0.00e+00 729.00
IUUC-Ppa-095670 Physcomitrella patens 35.90 3.00e-45 176.00
IUUC-Pfo-097251 Poecilia formosa 76.14 0.00e+00 638.00
IUUC-Pab-097842 Pongo abelii 93.03 0.00e+00 852.00
IUUC-Pop-099118 Populus trichocarpa 37.67 2.00e-42 166.00
IUUC-Pca-101077 Procavia capensis 81.35 0.00e+00 731.00
IUUC-Ppe-101706 Prunus persica 37.67 3.00e-41 162.00
IUUC-Pva-102245 Pteropus vampyrus 79.11 7.00e-146 509.00
IUUC-Smo-109165 Selaginella moellendorffii 42.58 2.00e-47 183.00
IUUC-Sit-109818 Setaria italica 41.50 1.00e-43 171.00
IUUC-Sly-111062 Solanum lycopersicum 38.58 1.00e-43 170.00
IUUC-Sbi-114298 Sorghum bicolor 39.34 3.00e-44 172.00
IUUC-Ssc-115779 Sus scrofa 92.23 0.00e+00 730.00
IUUC-Tgu-117378 Taeniopygia guttata 79.19 0.00e+00 728.00
IUUC-Tru-118515 Takifugu rubripes 71.62 7.00e-173 600.00
IUUC-Tsy-119555 Tarsius syrichta 84.72 0.00e+00 759.00
IUUC-Tni-119679 Tetraodon nigroviridis 70.60 1.00e-169 589.00
IUUC-Tca-121374 Theobroma cacao 37.64 3.00e-32 133.00
IUUC-Tae-123098 Triticum aestivum 32.60 1.00e-51 197.00
IUUC-Tur-126689 Triticum urartu 30.99 6.00e-17 82.00
IUUC-Vpa-130719 Vicugna pacos 83.15 0.00e+00 729.00
IUUC-Vvi-131014 Vitis vinifera 40.33 4.00e-40 159.00
IUUC-Xtr-131811 Xenopus tropicalis 72.20 0.00e+00 650.00
IUUC-Xma-133238 Xiphophorus maculatus 76.14 0.00e+00 640.00
Created Date 25-Jun-2017

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