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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046379
UUCD1 version UUC-HoS-00343
Ensembl Protein ID ENSP00000369415.2
UniProt Accession Q9BYV2; A5D8T7; Q53SY4; Q9BYV3; TRI54_HUMAN
Genbank Protein ID CAC32841.1; CAC32842.1; AAY24296.1; EAX00606.1; AAI41808.1
Protein Name Tripartite motif-containing protein 54; Muscle-specific RING finger protein; Muscle-specific RING finger protein 3; RING finger protein 30
Genbank Nucleotide ID AJ291714; AJ291714; AC013413; CH471053; BC141807
Gene Name TRIM54; MURF; MURF3; RNF30
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138100.13 ENST00000380075.6 ENSP00000369415.2
ENSG00000138100.13 ENST00000296098.4 ENSP00000296098.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbmiRTarBasemicroRNATRANSFAC
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17360532; 17786241
Classification
Family E-value Score Start End
E3 activity/RING/RING 8.10e-09 37.5 26 82
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...........pglknssskefrCPlCr 46
           C+iCle+f++++++lpC+H  +++C + +                ss ++frCP Cr
   Q: 26   CPICLEMFSKPVVILPCQHNLCRKCANDVfqasnplwqsrGSTTVSSGGRFRCPSCR 82
           *************************87777777888899977777899********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May bind and stabilize microtubules during myotubes formation.
 May bind and stabilize microtubules during myotubes formation.
Protein Sequence
(Fasta)
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP 60
LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHSKA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046379|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAGTAAAAT TAATCTGCTC TCTGGGGAGT AAGGGACAAA CAGTGCTACC CACAGAGTGA 60
ACAAGAGAGA GTCATTTGGG AAACAAAAGG AGAATTTTAC AGAGAGAGAG GGATAGCTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046379|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR017903--COS_domain
IPR033492--TRIM54
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51262--COS
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00336--BBOX
SM00184--RING
Gene Ontology

GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0030018--C:Z disc
GO:0004871--F:signal transducer activity
GO:0008270--F:zinc ion binding
GO:0007017--P:microtubule-based process
GO:0007275--P:multicellular organism development
GO:0055001--P:muscle cell development
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0007165--P:signal transduction
KEGG hsa:57159
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002282 Ailuropoda melanoleuca 97.83 6.00e-134 469.00
IUUC-Bta-013385 Bos taurus 97.30 6.00e-177 613.00
IUUC-Cja-019697 Callithrix jacchus 78.89 2.00e-138 485.00
IUUC-Cfa-020995 Canis familiaris 98.48 2.00e-169 588.00
IUUC-Cpo-021913 Cavia porcellus 96.67 0.00e+00 667.00
IUUC-Csa-023342 Chlorocebus sabaeus 98.33 0.00e+00 648.00
IUUC-Cin-025224 Ciona intestinalis 52.43 4.00e-94 338.00
IUUC-Csv-026374 Ciona savignyi 52.33 8.00e-82 296.00
IUUC-Dre-027562 Danio rerio 69.73 1.00e-144 506.00
IUUC-Dno-029582 Dasypus novemcinctus 98.18 4.00e-171 594.00
IUUC-Dor-031139 Dipodomys ordii 94.15 0.00e+00 639.00
IUUC-Ete-032346 Echinops telfairi 99.51 6.00e-109 387.00
IUUC-Eca-033645 Equus caballus 97.90 2.00e-178 618.00
IUUC-Eeu-035333 Erinaceus europaeus 69.12 2.00e-115 409.00
IUUC-Fca-035865 Felis catus 97.88 0.00e+00 629.00
IUUC-Fal-036978 Ficedula albicollis 81.46 3.00e-166 577.00
IUUC-Gga-040452 Gallus gallus 78.41 1.00e-162 566.00
IUUC-Ggo-044467 Gorilla gorilla 89.25 3.00e-176 610.00
IUUC-Itr-047912 Ictidomys tridecemlineatus 95.26 0.00e+00 631.00
IUUC-Lch-050029 Latimeria chalumnae 78.35 7.00e-153 533.00
IUUC-Loc-051801 Lepisosteus oculatus 80.97 7.00e-136 476.00
IUUC-Laf-054215 Loxodonta africana 96.39 0.00e+00 665.00
IUUC-Mcc-055027 Macaca mulatta 88.31 0.00e+00 631.00
IUUC-Meu-056412 Macropus eugenii 93.54 1.00e-165 575.00
IUUC-Mmr-060920 Microcebus murinus 96.94 0.00e+00 654.00
IUUC-Mdo-062832 Monodelphis domestica 96.66 8.00e-165 572.00
IUUC-Mmu-063707 Mus musculus 93.89 1.00e-176 612.00
IUUC-Mlu-067653 Myotis lucifugus 81.54 3.00e-138 484.00
IUUC-Nle-069020 Nomascus leucogenys 99.44 0.00e+00 659.00
IUUC-Opr-070577 Ochotona princeps 79.25 2.00e-143 501.00
IUUC-Ont-072491 Oreochromis niloticus 62.25 3.00e-120 424.00
IUUC-Oan-073101 Ornithorhynchus anatinus 95.45 3.00e-172 597.00
IUUC-Ocu-074454 Oryctolagus cuniculus 96.11 2.00e-179 621.00
IUUC-Oga-088361 Otolemur garnettii 99.40 1.00e-176 612.00
IUUC-Oar-089950 Ovis aries 81.38 6.00e-140 490.00
IUUC-Ptr-090785 Pan troglodytes 89.50 4.00e-177 613.00
IUUC-Pan-092344 Papio anubis 98.61 0.00e+00 651.00
IUUC-Pab-098322 Pongo abelii 96.09 0.00e+00 625.00
IUUC-Pca-100385 Procavia capensis 76.43 6.00e-121 426.00
IUUC-Rno-105134 Rattus norvegicus 95.28 0.00e+00 673.00
IUUC-Sha-106768 Sarcophilus harrisii 96.35 1.00e-177 615.00
IUUC-Tgu-117494 Taeniopygia guttata 80.12 2.00e-157 548.00
Created Date 25-Jun-2017

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