iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062547

UUCD1 version

UUC-MoD-00719

Ensembl Protein ID

ENSMODP00000002994.2

UniProt Accession

F7DDS2; F7DDS2_MONDO

Protein Name

Uncharacterized protein

Gene Name

HECTD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000025335.1	ENSMODT00000003056.2	ENSMODP00000002994.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.90e-76	255.9	90	415

Active Site

Position(s)	Description	Evidence
385	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 9    levefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrlld 89
           +e++f  E+ +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  +++  +e++G+l+g al+ +++l 
   Q: 90   WECKFIAESIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTANQGNGTGEARDMYVPNPscREFAKYEWIGQLMGAALRGKEFLV 178
           45*****************************9999*99**********************9999999********************** PP
   S: 90   lplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeYv 174
           l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++ +     ++++++++f    + +++l++++ +eL+pgG+ + V +e++ +++
   Q: 179  LALPGFVWKQLSGEEVSWsKDFSAVDSVLVKLLEVMEVM-----DKETFEFKFGqelTYTTVLSDQRMVELVPGGAATAVCYEDRGRFI 262
           *************************************77.....455566666633445566999************************ PP
   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +lv ++rl+e  keqv+a+++G+ +v+p+ +l+l+t++ele  +cG++e++v++l+k t++++ +++++  +q+Fwe+l++f++e+r++
   Q: 263  RLVQQARLEE-SKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDTRVQYFWEALNNFTNEDRSR 349
           *********9.9*************************************************76.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           fL+FvTg+srlP+        r++++++   ++++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 350  FLRFVTGRSRLPA--------RIYIYPDklgSETTDALPESSTCSSTLFLPHYVSAKVCEEKLRYAAYNCVAID 415
           ************5........66777777989999*********************************998776 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

LQQVKQFLLL SRRRPALVSQ CLRDSETGKP SIMPRLYINR RLAMEHRDCP ARDTSCKNAV 60
FTQVYEGLKP SDKYEKPLDY RWPLRYDQWW ECKFIAESII DQGGGFRDSL ADMSEELCPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCAGCAAG TCAAGCAGTT CCTGCTGCTG TCTCGCCGGC GCCCGGCCCT CGTGTCCCAG 60
TGTCTGCGCG ACTCCGAGAC CGGCAAGCCC AGCATCATGC CCCGTCTGTA CATCAACCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	92.20	0.00e+00	813.00
IUUC-Apl-003715	Anas platyrhynchos	90.07	0.00e+00	779.00
IUUC-Aca-004377	Anolis carolinensis	88.42	0.00e+00	767.00
IUUC-Ame-011918	Astyanax mexicanus	77.07	0.00e+00	677.00
IUUC-Bta-012736	Bos taurus	92.43	0.00e+00	816.00
IUUC-Cja-019926	Callithrix jacchus	92.43	0.00e+00	818.00
IUUC-Cfa-020753	Canis familiaris	92.20	0.00e+00	818.00
IUUC-Cpo-021415	Cavia porcellus	92.20	0.00e+00	816.00
IUUC-Csa-023096	Chlorocebus sabaeus	92.20	0.00e+00	815.00
IUUC-Dre-028746	Danio rerio	80.61	0.00e+00	684.00
IUUC-Dno-029293	Dasypus novemcinctus	92.20	0.00e+00	818.00
IUUC-Dor-031113	Dipodomys ordii	92.43	0.00e+00	821.00
IUUC-Ete-032601	Echinops telfairi	89.60	0.00e+00	791.00
IUUC-Eca-034198	Equus caballus	91.73	0.00e+00	811.00
IUUC-Eeu-034708	Erinaceus europaeus	91.49	0.00e+00	807.00
IUUC-Fca-035478	Felis catus	92.43	0.00e+00	816.00
IUUC-Fal-037366	Ficedula albicollis	89.60	0.00e+00	775.00
IUUC-Gmo-039020	Gadus morhua	77.36	0.00e+00	689.00
IUUC-Gga-040332	Gallus gallus	89.60	0.00e+00	773.00
IUUC-Gac-042336	Gasterosteus aculeatus	80.24	0.00e+00	714.00
IUUC-Ggo-045382	Gorilla gorilla	92.20	0.00e+00	815.00
IUUC-Hsa-046562	Homo sapiens	92.20	0.00e+00	815.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	92.67	0.00e+00	817.00
IUUC-Lch-049606	Latimeria chalumnae	75.85	6.00e-146	511.00
IUUC-Loc-052448	Lepisosteus oculatus	64.55	4.00e-151	528.00
IUUC-Laf-054507	Loxodonta africana	90.80	0.00e+00	802.00
IUUC-Mcc-055690	Macaca mulatta	92.20	0.00e+00	815.00
IUUC-Meu-055970	Macropus eugenii	96.22	0.00e+00	816.00
IUUC-Mga-059654	Meleagris gallopavo	90.07	0.00e+00	777.00
IUUC-Mmr-061069	Microcebus murinus	92.67	0.00e+00	818.00
IUUC-Mmu-063096	Mus musculus	91.96	0.00e+00	813.00
IUUC-Mpu-065846	Mustela putorius furo	92.43	0.00e+00	816.00
IUUC-Mlu-067992	Myotis lucifugus	91.73	0.00e+00	810.00
IUUC-Nle-069565	Nomascus leucogenys	91.67	0.00e+00	714.00
IUUC-Opr-070853	Ochotona princeps	75.48	0.00e+00	634.00
IUUC-Ont-071628	Oreochromis niloticus	79.67	0.00e+00	682.00
IUUC-Ocu-074094	Oryctolagus cuniculus	93.14	0.00e+00	820.00
IUUC-Ola-087384	Oryzias latipes	79.48	0.00e+00	716.00
IUUC-Oga-088224	Otolemur garnettii	92.20	0.00e+00	817.00
IUUC-Oar-090043	Ovis aries	91.25	0.00e+00	801.00
IUUC-Ptr-090852	Pan troglodytes	91.96	0.00e+00	813.00
IUUC-Pan-092787	Papio anubis	92.20	0.00e+00	816.00
IUUC-Psi-092986	Pelodiscus sinensis	79.58	0.00e+00	663.00
IUUC-Pma-094416	Petromyzon marinus	47.86	2.00e-107	383.00
IUUC-Pfo-096720	Poecilia formosa	80.38	0.00e+00	716.00
IUUC-Pab-098325	Pongo abelii	83.33	2.00e-130	459.00
IUUC-Pca-100885	Procavia capensis	78.81	0.00e+00	664.00
IUUC-Pva-102829	Pteropus vampyrus	98.64	3.00e-82	299.00
IUUC-Rno-104882	Rattus norvegicus	92.20	0.00e+00	815.00
IUUC-Sha-106811	Sarcophilus harrisii	91.30	6.00e-58	218.00
IUUC-Sar-113020	Sorex araneus	78.62	0.00e+00	674.00
IUUC-Tgu-117042	Taeniopygia guttata	90.07	0.00e+00	777.00
IUUC-Tru-118419	Takifugu rubripes	79.67	0.00e+00	719.00
IUUC-Tsy-118829	Tarsius syrichta	89.78	1.00e-73	271.00
IUUC-Tni-120410	Tetraodon nigroviridis	58.63	1.00e-137	483.00
IUUC-Tbe-128113	Tupaia belangeri	92.43	0.00e+00	736.00
IUUC-Ttr-128167	Tursiops truncatus	83.92	0.00e+00	717.00
IUUC-Xtr-132910	Xenopus tropicalis	80.61	0.00e+00	660.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence