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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063840
UUCD1 version UUC-MuM-00686
Ensembl Protein ID ENSMUSP00000071896.4
UniProt Accession Q8BZT2; B2RQJ2; Q80VJ1; Q8C122; Q8C1E3; SH3R2_MOUSE
Genbank Protein ID BAC25780.1; BAC26334.1; BAC28382.1; AAH48400.1; AAI37956.1; AAI45061.1
Protein Name Putative E3 ubiquitin-protein ligase SH3RF2; Protein phosphatase 1 regulatory subunit 39; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2
Genbank Nucleotide ID AK028153; AK029168; AK033601; BC048400; BC137955; BC145060
Gene Name Sh3rf2; Ppp1r39; Rnf158
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000057719.10 ENSMUST00000072008.10 ENSMUSP00000071896.4
ENSMUSG00000057719.10 ENSMUST00000074679.3 ENSMUSP00000074247.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.60e-07 32.8 12 53
UBD/SH3 7.10e-29 100.7 384 440
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+e ++   +vlpC+H+f++ Clq++     ++ ke rCP Cr
   Q: 12   CPVCFEKLDVTAKVLPCQHTFCKPCLQRI----FKAHKELRCPECR 53
           ********88899****************....99**********8 PP
   

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ + +l+ y+a   +eL l+kG+ ++v+   +   gWlkg + l+g+ G+fP+++v  
   Q: 384  NNMFVALHTYSAHRPEELDLQKGEGIRVL--GKYQDGWLKGLSLLTGRTGIFPSDYVIP 440
           67899************************..555679*******************965 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function (By similarity).
 Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function (By similarity).
Protein Sequence
(Fasta)
MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRI FKAHKELRCP ECRTLVFCSI 60
EALPANLLLV RLLDGVRSGQ SSWKGGSFRR PRILTLQDNR KAKSSPRSLQ ASPFRLVPSV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063840|E3,RING;UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACACCTCTCA GGGCAGTCAC ATTTTTTTTT CCTCCTTTCA AACAGGCAGG GAGTTCTGAT 60
GCTCCCAAAA GACCAGCTCT ACCCCCTCGG CTCGCTGCCC CTACAATGTG GATCCTGCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063840|E3,RING;UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0650--Protein phosphatase inhibitor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011511--SH3_2
IPR001452--SH3_domain
IPR028511--SH3RF2
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00018--SH3_1
PF07653--SH3_2
PF00097--zf-C3HC4
PRINTS

PR00452--SH3DOMAIN
SMART

SM00184--RING
SM00326--SH3
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0019902--F:phosphatase binding
GO:0008157--F:protein phosphatase 1 binding
GO:0004864--F:protein phosphatase inhibitor activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0010923--P:negative regulation of phosphatase activity
GO:0016567--P:protein ubiquitination
KEGG mmu:269016
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001594 Ailuropoda melanoleuca 79.01 0.00e+00 1036.00
IUUC-Apl-003443 Anas platyrhynchos 56.73 6.00e-172 597.00
IUUC-Aca-004632 Anolis carolinensis 51.71 6.00e-171 594.00
IUUC-Bta-013400 Bos taurus 79.75 0.00e+00 980.00
IUUC-Cja-019686 Callithrix jacchus 70.29 0.00e+00 878.00
IUUC-Cfa-020893 Canis familiaris 80.06 0.00e+00 1041.00
IUUC-Cpo-021638 Cavia porcellus 75.62 0.00e+00 971.00
IUUC-Csa-023846 Chlorocebus sabaeus 81.27 0.00e+00 1069.00
IUUC-Cho-024609 Choloepus hoffmanni 80.26 3.00e-160 558.00
IUUC-Dno-028940 Dasypus novemcinctus 77.95 0.00e+00 1016.00
IUUC-Dor-030491 Dipodomys ordii 71.06 6.00e-123 434.00
IUUC-Ete-032513 Echinops telfairi 76.45 0.00e+00 997.00
IUUC-Eca-034241 Equus caballus 81.54 0.00e+00 1096.00
IUUC-Eeu-034636 Erinaceus europaeus 73.00 0.00e+00 851.00
IUUC-Fca-035862 Felis catus 77.34 0.00e+00 1025.00
IUUC-Gga-040748 Gallus gallus 52.29 9.00e-146 510.00
IUUC-Ggo-045267 Gorilla gorilla 80.85 0.00e+00 1065.00
IUUC-Hsa-045761 Homo sapiens 80.58 0.00e+00 1058.00
IUUC-Itr-048226 Ictidomys tridecemlineatus 78.24 0.00e+00 999.00
IUUC-Lch-050498 Latimeria chalumnae 44.93 5.00e-121 428.00
IUUC-Laf-054061 Loxodonta africana 71.57 0.00e+00 752.00
IUUC-Mcc-054746 Macaca mulatta 80.33 0.00e+00 1026.00
IUUC-Meu-056390 Macropus eugenii 55.38 2.00e-81 296.00
IUUC-Mga-059398 Meleagris gallopavo 63.84 8.00e-93 333.00
IUUC-Mmr-061390 Microcebus murinus 76.23 0.00e+00 837.00
IUUC-Mdo-062951 Monodelphis domestica 69.27 0.00e+00 936.00
IUUC-Mpu-065840 Mustela putorius furo 79.09 0.00e+00 1063.00
IUUC-Mlu-067378 Myotis lucifugus 78.85 0.00e+00 995.00
IUUC-Nle-069535 Nomascus leucogenys 78.10 0.00e+00 993.00
IUUC-Opr-070739 Ochotona princeps 76.58 0.00e+00 973.00
IUUC-Oan-073468 Ornithorhynchus anatinus 62.60 0.00e+00 770.00
IUUC-Ocu-074343 Oryctolagus cuniculus 77.46 0.00e+00 951.00
IUUC-Oga-088276 Otolemur garnettii 73.00 0.00e+00 941.00
IUUC-Oar-090315 Ovis aries 78.95 0.00e+00 979.00
IUUC-Ptr-091119 Pan troglodytes 80.44 0.00e+00 1060.00
IUUC-Pan-092158 Papio anubis 81.77 0.00e+00 769.00
IUUC-Psi-092959 Pelodiscus sinensis 58.42 0.00e+00 729.00
IUUC-Pab-097675 Pongo abelii 80.72 0.00e+00 1055.00
IUUC-Pca-101021 Procavia capensis 70.88 0.00e+00 897.00
IUUC-Pva-102619 Pteropus vampyrus 79.86 0.00e+00 999.00
IUUC-Rno-105918 Rattus norvegicus 92.29 0.00e+00 1248.00
IUUC-Sha-107391 Sarcophilus harrisii 65.78 0.00e+00 853.00
IUUC-Sar-113148 Sorex araneus 75.17 1.00e-175 609.00
IUUC-Ssc-116219 Sus scrofa 71.79 4.00e-118 417.00
IUUC-Tgu-116584 Taeniopygia guttata 51.56 2.00e-105 376.00
IUUC-Tsy-118968 Tarsius syrichta 78.46 2.00e-159 555.00
IUUC-Tbe-128007 Tupaia belangeri 82.91 0.00e+00 766.00
IUUC-Ttr-128499 Tursiops truncatus 77.96 0.00e+00 1034.00
IUUC-Vpa-130075 Vicugna pacos 73.11 2.00e-73 270.00
Created Date 25-Jun-2017

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