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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045810
Ensembl Protein ID ENSP00000347852.5
UniProt Accession O94875; A6NEK9; B3KPQ7; B7Z1G5; B7Z3X6; C9JKV9; D3DP62; D3DP63; E9PAS5; E9PAW4; G3XAI0; H7BXR4; J3KNZ5; O60592; O60593; Q96EX0; SRBS2_HUMAN
Genbank Protein ID AAC05508.1; AAC05509.1; BAA34497.2; BAG51769.1; BAH11501.1; BAH12362.1; EAX04630.1; EAX04631.1; EAX04632.1; EAX04635.1; EAX04636.1; AAH11883.1
Protein Name Sorbin and SH3 domain-containing protein 2; Arg-binding protein 2; Arg/Abl-interacting protein 2; Sorbin
Genbank Nucleotide ID AF049884; AF049885; AB018320; AK056628; AK293400; AK296461; AK225327; CH471056; CH471056; CH471056; CH471056; BC011883
Gene Name SORBS2; ARGBP2; KIAA0777
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000154556.17 ENST00000437304.6 ENSP00000396008.2
ENSG00000154556.17 ENST00000319471.13 ENSP00000322182.9
ENSG00000154556.17 ENST00000449407.6 ENSP00000397262.2
ENSG00000154556.17 ENST00000355634.9 ENSP00000347852.5
ENSG00000154556.17 ENST00000393528.7 ENSP00000377162.3
ENSG00000154556.17 ENST00000319454.10 ENSP00000321983.6
ENSG00000154556.17 ENST00000438278.5 ENSP00000389995.1
ENSG00000154556.17 ENST00000445625.1 ENSP00000391940.1
ENSG00000154556.17 ENST00000444781.5 ENSP00000396183.1
ENSG00000154556.17 ENST00000421639.5 ENSP00000405646.1
ENSG00000154556.17 ENST00000451701.5 ENSP00000404430.1
ENSG00000154556.17 ENST00000428330.5 ENSP00000402328.1
ENSG00000154556.17 ENST00000421420.5 ENSP00000393258.1
ENSG00000154556.17 ENST00000418609.5 ENSP00000397482.1
ENSG00000154556.17 ENST00000448662.6 ENSP00000409158.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProtPHOSIDA
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 8.00e-38 129.9 1146 1200
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +q+ly+y++ n+deL+l++ dv++v+  e+ d gW +g++  ++  G fP n+v++l
   Q: 1146 FQALYNYTPRNEDELELRESDVIDVM--EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1200
           79***********************9..999***********************996 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
 Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
Protein Sequence
(Fasta)
MNTDSGGCAR KRAAMSVTLT SVKRVQSSPN LLAAGRDSQS PDSAWRSYND GNQETLNGDA 60
TYSSLAAKGF RSVRPNLQDK RSPTQSQITV NGNSGGAVSP MSYYQRPFSP SAYSLPASLN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045810|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
TTTTATTACG TCTCTCCTTG TGGATTACGT AGAACTTTGG AAAATTAAAC ATTAGACATC 60
TTCATAGAAA ATCATGTCAC TGATTTTTAA AGCCAGCTCA ATTTAACCTG CCACTGATTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045810|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0027--Amidation
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0832--Ubl conjugation
Interpro

IPR028516--ArgBP2
IPR001452--SH3_domain
IPR003127--SoHo_dom
IPR013087--Znf_C2H2_type
PROSITE

PS50002--SH3
PS50831--SOHO
Pfam

PF00018--SH3_1
PF14604--SH3_9
PF02208--Sorb
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
SM00459--Sorb
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016324--C:apical plasma membrane
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0008093--F:cytoskeletal adaptor activity
GO:0046872--F:metal ion binding
GO:0003723--F:RNA binding
GO:0005200--F:structural constituent of cytoskeleton
GO:0008307--F:structural constituent of muscle
GO:0007015--P:actin filament organization
GO:0007155--P:cell adhesion
GO:0061049--P:cell growth involved in cardiac muscle cell development
GO:0016477--P:cell migration
KEGG hsa:8470
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001503 Ailuropoda melanoleuca 89.70 0.00e+00 2041.00
IUUC-Apl-003194 Anas platyrhynchos 77.00 0.00e+00 1526.00
IUUC-Aca-004601 Anolis carolinensis 74.36 0.00e+00 1659.00
IUUC-Ame-011835 Astyanax mexicanus 55.81 3.00e-167 583.00
IUUC-Cja-019127 Callithrix jacchus 94.26 0.00e+00 2081.00
IUUC-Cfa-020779 Canis familiaris 91.06 0.00e+00 2025.00
IUUC-Cpo-021509 Cavia porcellus 87.20 0.00e+00 1947.00
IUUC-Csa-023258 Chlorocebus sabaeus 93.74 0.00e+00 1560.00
IUUC-Cho-024653 Choloepus hoffmanni 86.84 0.00e+00 1168.00
IUUC-Dre-027543 Danio rerio 52.29 0.00e+00 914.00
IUUC-Dno-029585 Dasypus novemcinctus 80.22 0.00e+00 1717.00
IUUC-Dor-031047 Dipodomys ordii 86.76 0.00e+00 1780.00
IUUC-Dme-032104 Drosophila melanogaster 45.39 8.00e-59 224.00
IUUC-Ete-033186 Echinops telfairi 82.84 0.00e+00 1331.00
IUUC-Eca-033574 Equus caballus 96.64 3.00e-146 512.00
IUUC-Eeu-034786 Erinaceus europaeus 93.61 3.00e-130 459.00
IUUC-Fca-036437 Felis catus 90.13 0.00e+00 1817.00
IUUC-Fal-036738 Ficedula albicollis 77.45 0.00e+00 1504.00
IUUC-Gmo-039436 Gadus morhua 61.74 2.00e-83 304.00
IUUC-Gga-040705 Gallus gallus 88.81 2.00e-133 469.00
IUUC-Gac-041942 Gasterosteus aculeatus 47.23 2.00e-168 586.00
IUUC-Ggo-044915 Gorilla gorilla 97.33 0.00e+00 2202.00
IUUC-Itr-048982 Ictidomys tridecemlineatus 90.55 0.00e+00 2068.00
IUUC-Lch-050409 Latimeria chalumnae 66.25 0.00e+00 1224.00
IUUC-Loc-051858 Lepisosteus oculatus 61.65 0.00e+00 1124.00
IUUC-Laf-053914 Loxodonta africana 89.42 0.00e+00 2011.00
IUUC-Mcc-055831 Macaca mulatta 94.96 0.00e+00 1773.00
IUUC-Meu-056682 Macropus eugenii 83.71 0.00e+00 930.00
IUUC-Mga-059448 Meleagris gallopavo 73.91 0.00e+00 1277.00
IUUC-Mmr-061058 Microcebus murinus 87.36 0.00e+00 1597.00
IUUC-Mdo-062277 Monodelphis domestica 77.62 2.00e-136 480.00
IUUC-Mmu-063626 Mus musculus 86.98 0.00e+00 2022.00
IUUC-Mpu-066464 Mustela putorius furo 87.97 0.00e+00 1424.00
IUUC-Mlu-067667 Myotis lucifugus 84.04 0.00e+00 1925.00
IUUC-Nle-069677 Nomascus leucogenys 96.04 0.00e+00 2156.00
IUUC-Opr-070844 Ochotona princeps 86.78 0.00e+00 1779.00
IUUC-Ont-071980 Oreochromis niloticus 50.58 0.00e+00 930.00
IUUC-Oan-073581 Ornithorhynchus anatinus 54.69 1.00e-167 583.00
IUUC-Ocu-074553 Oryctolagus cuniculus 88.98 0.00e+00 2012.00
IUUC-Ola-087178 Oryzias latipes 47.27 0.00e+00 774.00
IUUC-Oga-088984 Otolemur garnettii 90.67 0.00e+00 2007.00
IUUC-Oar-090142 Ovis aries 96.27 1.00e-144 506.00
IUUC-Ptr-090880 Pan troglodytes 97.28 0.00e+00 1975.00
IUUC-Pan-091761 Papio anubis 94.27 0.00e+00 1912.00
IUUC-Psi-093241 Pelodiscus sinensis 77.06 0.00e+00 1722.00
IUUC-Pfo-096481 Poecilia formosa 48.47 0.00e+00 748.00
IUUC-Pab-098118 Pongo abelii 91.18 0.00e+00 1503.00
IUUC-Pca-100371 Procavia capensis 72.86 0.00e+00 634.00
IUUC-Pva-102275 Pteropus vampyrus 91.12 0.00e+00 1898.00
IUUC-Rno-105832 Rattus norvegicus 87.45 0.00e+00 1987.00
IUUC-Sha-107564 Sarcophilus harrisii 83.98 0.00e+00 1882.00
IUUC-Sar-113106 Sorex araneus 88.03 0.00e+00 1800.00
IUUC-Tgu-116594 Taeniopygia guttata 75.60 0.00e+00 1573.00
IUUC-Tru-117686 Takifugu rubripes 47.88 0.00e+00 849.00
IUUC-Tsy-119376 Tarsius syrichta 85.47 0.00e+00 707.00
IUUC-Tni-119800 Tetraodon nigroviridis 62.64 5.00e-92 332.00
IUUC-Tbe-127334 Tupaia belangeri 86.06 0.00e+00 1541.00
IUUC-Ttr-128705 Tursiops truncatus 90.12 0.00e+00 1810.00
IUUC-Vpa-130293 Vicugna pacos 89.76 0.00e+00 1855.00
IUUC-Xtr-131872 Xenopus tropicalis 66.18 0.00e+00 1303.00
Created Date 25-Jun-2017

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