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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105246
UUCD1 version UUC-RaN-00602
Ensembl Protein ID ENSRNOP00000069447.1
UniProt Accession A0A0G2JVE0; A0A0G2JVE0_RAT
Genbank Protein ID ENSRNOP00000069447
Protein Name F-box and WD repeat domain-containing 11
Genbank Nucleotide ID AABR07029244
Gene Name Fbxw11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000004395.7 ENSRNOT00000064079.2 ENSRNOP00000059948.1
ENSRNOG00000004395.7 ENSRNOT00000079698.1 ENSRNOP00000069447.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.00e-57 188.9 430 464
UBD/Beta-Prp 1.80e-69 234.6 343 508
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 430  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 464
           8**********.44****************977665 PP
   

   UBD/Beta-Prp
   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 343  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 426
           4556679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 427  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 508
           ***************9..***********************************99.************..99**************7 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MCALSCLQSM PSVRCLQNTS VMEDQNEDES PKKSALWQIS NGTSSVIVSR KRPSEGNYQK 60
EKDLCIKYFD QWSESDQVEF VEHLISRMCH YQHGHINSYL KPMLQRDFIT ALPEQGLDHI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105246|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGCCCTGCC CTCCCCTAGG TGCTCTCTCC CGTGGCGGAA CCCTGGCAGA GTGGCCCGAC 60
GGCTTCTTGT TCCCATAAGG CTTAGCGATC CGCCGCGGTT GTTGGGAGTT GTAGTCTTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105246|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001397 Ailuropoda melanoleuca 95.67 0.00e+00 1041.00
IUUC-Apl-003449 Anas platyrhynchos 98.50 0.00e+00 1083.00
IUUC-Ani-009324 Aspergillus nidulans 29.87 5.00e-48 186.00
IUUC-Ang-009766 Aspergillus niger 31.65 2.00e-52 200.00
IUUC-Ame-011174 Astyanax mexicanus 87.27 0.00e+00 968.00
IUUC-Bta-012920 Bos taurus 98.46 0.00e+00 1061.00
IUUC-Cel-018392 Caenorhabditis elegans 63.36 0.00e+00 636.00
IUUC-Cja-018879 Callithrix jacchus 95.67 0.00e+00 1041.00
IUUC-Cfa-020021 Canis familiaris 95.67 0.00e+00 1041.00
IUUC-Cpo-022151 Cavia porcellus 98.83 0.00e+00 1049.00
IUUC-Csa-024095 Chlorocebus sabaeus 99.22 0.00e+00 1050.00
IUUC-Cho-024658 Choloepus hoffmanni 90.87 2.00e-132 466.00
IUUC-Cin-025188 Ciona intestinalis 80.63 0.00e+00 825.00
IUUC-Dre-028160 Danio rerio 89.62 0.00e+00 962.00
IUUC-Dno-029485 Dasypus novemcinctus 89.00 0.00e+00 928.00
IUUC-Dor-030498 Dipodomys ordii 95.29 0.00e+00 1034.00
IUUC-Eca-033804 Equus caballus 95.59 0.00e+00 1022.00
IUUC-Fca-035887 Felis catus 99.03 0.00e+00 1061.00
IUUC-Fal-036783 Ficedula albicollis 98.68 0.00e+00 1088.00
IUUC-Gmo-038590 Gadus morhua 87.01 0.00e+00 939.00
IUUC-Gga-040628 Gallus gallus 98.31 0.00e+00 1083.00
IUUC-Gac-041305 Gasterosteus aculeatus 86.82 0.00e+00 944.00
IUUC-Ggo-044604 Gorilla gorilla 95.67 0.00e+00 1041.00
IUUC-Hsa-046139 Homo sapiens 95.67 0.00e+00 1041.00
IUUC-Lch-050460 Latimeria chalumnae 97.08 0.00e+00 1036.00
IUUC-Laf-053968 Loxodonta africana 99.25 0.00e+00 1093.00
IUUC-Mcc-055822 Macaca mulatta 96.15 0.00e+00 1081.00
IUUC-Mga-059225 Meleagris gallopavo 98.25 0.00e+00 1042.00
IUUC-Mvi-060284 Microbotryum violaceum 44.95 1.00e-69 258.00
IUUC-Mmr-060746 Microcebus murinus 95.67 0.00e+00 1041.00
IUUC-Mdo-062005 Monodelphis domestica 98.63 0.00e+00 1046.00
IUUC-Mmu-063851 Mus musculus 100.00 0.00e+00 1098.00
IUUC-Mpu-065716 Mustela putorius furo 98.45 0.00e+00 1055.00
IUUC-Mlu-067001 Myotis lucifugus 99.22 0.00e+00 1050.00
IUUC-Nle-069788 Nomascus leucogenys 96.12 0.00e+00 1019.00
IUUC-Opr-071229 Ochotona princeps 95.48 0.00e+00 1039.00
IUUC-Ont-071792 Oreochromis niloticus 87.38 0.00e+00 951.00
IUUC-Oan-072782 Ornithorhynchus anatinus 98.68 0.00e+00 1088.00
IUUC-Ocu-074894 Oryctolagus cuniculus 99.25 0.00e+00 1093.00
IUUC-Ola-086985 Oryzias latipes 88.58 0.00e+00 974.00
IUUC-Oga-088604 Otolemur garnettii 92.75 0.00e+00 1041.00
IUUC-Oar-090412 Ovis aries 99.25 0.00e+00 1093.00
IUUC-Ptr-091039 Pan troglodytes 95.86 0.00e+00 1042.00
IUUC-Pan-092770 Papio anubis 99.21 0.00e+00 1045.00
IUUC-Psi-093887 Pelodiscus sinensis 97.93 0.00e+00 1078.00
IUUC-Pno-094808 Phaeosphaeria nodorum 29.50 2.00e-45 177.00
IUUC-Pfo-096783 Poecilia formosa 88.95 0.00e+00 977.00
IUUC-Pva-102547 Pteropus vampyrus 95.48 0.00e+00 1035.00
IUUC-Sha-107339 Sarcophilus harrisii 98.63 0.00e+00 1046.00
IUUC-Sja-107743 Schizosaccharomyces japonicus 35.32 4.00e-74 271.00
IUUC-Spo-108200 Schizosaccharomyces pombe 32.20 6.00e-66 244.00
IUUC-Tgu-116541 Taeniopygia guttata 98.49 0.00e+00 1083.00
IUUC-Tru-117671 Takifugu rubripes 88.39 0.00e+00 969.00
IUUC-Tni-120359 Tetraodon nigroviridis 89.58 0.00e+00 951.00
IUUC-Tbe-127418 Tupaia belangeri 89.45 0.00e+00 955.00
IUUC-Ttr-129131 Tursiops truncatus 95.67 0.00e+00 1040.00
IUUC-Vpa-130668 Vicugna pacos 95.67 0.00e+00 1040.00
IUUC-Xma-133187 Xiphophorus maculatus 95.36 5.00e-158 549.00
Created Date 25-Jun-2017

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