iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023805

Ensembl Protein ID

ENSCSAP00000009205.1

UniProt Accession

A0A0D9RKR6; A0A0D9RKR6_CHLSB

Genbank Protein ID

ENSCSAP00000009205

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01087657

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000013079.1	ENSCSAT00000011123.1	ENSCSAP00000009205.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.10e-135	450.4	349	683

Active Site

Position(s)	Description	Evidence
652	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 349  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 436
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 437  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 522
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 523  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 610
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk......prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+      p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 611  TGTCRLPLGGFAELMgvgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 683
           ***********************************************************************96 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

SVNGESSSFA PTDNASVTGT PVVSEENALS PNCTSTTVED PPVQEILTSS ENNECIPSTS 60
AELGSEARSI LEPDTSNSRS SSAFEAAKSR QPDGCVDPVR QQSGNANAET LPSGWEQRKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGTTAATG GAGAATCATC CTCATTTGCA CCAACTGATA ATGCTTCTGT CACGGGTACT 60
CCAGTAGTGT CTGAAGAAAA TGCCTTGTCT CCAAATTGCA CTAGTACTAC TGTTGAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	95.47	0.00e+00	1335.00
IUUC-Apl-003310	Anas platyrhynchos	85.67	0.00e+00	1179.00
IUUC-Aca-005388	Anolis carolinensis	84.77	0.00e+00	1171.00
IUUC-Bta-012857	Bos taurus	95.47	0.00e+00	1315.00
IUUC-Cel-018299	Caenorhabditis elegans	67.13	0.00e+00	830.00
IUUC-Cja-019448	Callithrix jacchus	98.10	0.00e+00	1382.00
IUUC-Cfa-020728	Canis familiaris	96.20	0.00e+00	1357.00
IUUC-Cpo-021635	Cavia porcellus	90.38	0.00e+00	1284.00
IUUC-Cho-024943	Choloepus hoffmanni	83.77	0.00e+00	1120.00
IUUC-Cin-025212	Ciona intestinalis	73.62	0.00e+00	897.00
IUUC-Csv-026256	Ciona savignyi	72.59	0.00e+00	891.00
IUUC-Dre-028245	Danio rerio	91.10	0.00e+00	1137.00
IUUC-Dno-029618	Dasypus novemcinctus	96.35	0.00e+00	1337.00
IUUC-Dme-032041	Drosophila melanogaster	71.12	0.00e+00	889.00
IUUC-Ete-032779	Echinops telfairi	94.91	0.00e+00	1107.00
IUUC-Eca-033313	Equus caballus	94.79	0.00e+00	1265.00
IUUC-Eeu-035259	Erinaceus europaeus	84.94	0.00e+00	1165.00
IUUC-Fca-035420	Felis catus	96.78	0.00e+00	1360.00
IUUC-Fal-037335	Ficedula albicollis	85.53	0.00e+00	1185.00
IUUC-Gmo-039172	Gadus morhua	86.49	0.00e+00	1040.00
IUUC-Gga-040246	Gallus gallus	86.48	0.00e+00	1190.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.31	0.00e+00	1150.00
IUUC-Ggo-045001	Gorilla gorilla	98.68	0.00e+00	1387.00
IUUC-Hsa-046544	Homo sapiens	98.83	0.00e+00	1395.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	93.89	0.00e+00	1324.00
IUUC-Lch-050398	Latimeria chalumnae	92.86	0.00e+00	1153.00
IUUC-Loc-052116	Lepisosteus oculatus	93.37	0.00e+00	1166.00
IUUC-Laf-053551	Loxodonta africana	94.01	0.00e+00	1280.00
IUUC-Meu-056455	Macropus eugenii	67.40	0.00e+00	815.00
IUUC-Mla-058996	Melampsora laricipopulina	44.86	5.00e-148	518.00
IUUC-Mga-059986	Meleagris gallopavo	85.32	0.00e+00	1193.00
IUUC-Mmr-060945	Microcebus murinus	92.70	0.00e+00	1288.00
IUUC-Mdo-063024	Monodelphis domestica	84.80	0.00e+00	1122.00
IUUC-Mmu-063202	Mus musculus	92.69	0.00e+00	1268.00
IUUC-Mpu-065773	Mustela putorius furo	96.05	0.00e+00	1358.00
IUUC-Nle-069188	Nomascus leucogenys	99.27	0.00e+00	1399.00
IUUC-Opr-070965	Ochotona princeps	93.26	0.00e+00	1248.00
IUUC-Ont-072226	Oreochromis niloticus	92.32	0.00e+00	1155.00
IUUC-Oan-073497	Ornithorhynchus anatinus	88.03	0.00e+00	1186.00
IUUC-Ocu-073891	Oryctolagus cuniculus	89.64	0.00e+00	1222.00
IUUC-Ola-087438	Oryzias latipes	89.14	0.00e+00	1153.00
IUUC-Oga-087922	Otolemur garnettii	96.35	0.00e+00	1367.00
IUUC-Oar-089429	Ovis aries	95.03	0.00e+00	1298.00
IUUC-Ptr-090484	Pan troglodytes	98.83	0.00e+00	1395.00
IUUC-Pan-092117	Papio anubis	99.56	0.00e+00	1403.00
IUUC-Psi-093338	Pelodiscus sinensis	85.99	0.00e+00	1189.00
IUUC-Pma-094279	Petromyzon marinus	74.83	0.00e+00	837.00
IUUC-Pfo-096171	Poecilia formosa	92.66	0.00e+00	1158.00
IUUC-Pab-098654	Pongo abelii	96.48	0.00e+00	1337.00
IUUC-Pva-102811	Pteropus vampyrus	92.17	0.00e+00	1203.00
IUUC-Rno-106125	Rattus norvegicus	92.69	0.00e+00	1277.00
IUUC-Sha-107243	Sarcophilus harrisii	86.94	0.00e+00	1186.00
IUUC-Ssc-115368	Sus scrofa	94.89	0.00e+00	1312.00
IUUC-Tgu-117079	Taeniopygia guttata	85.51	0.00e+00	1174.00
IUUC-Tru-118062	Takifugu rubripes	90.20	0.00e+00	1159.00
IUUC-Tsy-119507	Tarsius syrichta	90.20	0.00e+00	1244.00
IUUC-Tni-120151	Tetraodon nigroviridis	91.67	0.00e+00	1147.00
IUUC-Ttr-129260	Tursiops truncatus	82.02	0.00e+00	1087.00
IUUC-Uma-129332	Ustilago maydis	46.04	3.00e-143	502.00
IUUC-Xtr-132877	Xenopus tropicalis	80.77	0.00e+00	959.00
IUUC-Xma-133778	Xiphophorus maculatus	92.66	0.00e+00	1158.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence