iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.70e-14	55.1	76	149

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    Dvilvv..........ggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv +v+          g ++++ah+ vLaa S vF a+f++++  +  + ++e+ dv+p +f all+FlY++++++
   Q: 76   DVRFVLgkgrgaaaagGPQRIPAHRFVLAAGSAVFDAMFNGGMATT--SAEIELPDVEPAAFLALLRFLYSDEVQI 149
           6666666666666654489*************************88..69**********************9986 PP

Organism

Mus musculus

Functional Description
(View)

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MASLGSAAAG EPATGAEAEP GPPAPPPPPP PPPAPSPSAL GPLLPLQREP LYNWQATKAS 60
LKERFAFLFN SELLSDVRFV LGKGRGAAAA GGPQRIPAHR FVLAAGSAVF DAMFNGGMAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGGTGCTC GCAGCTTGAG CGGAGCCGCG CAGCAGGAGG ATGGCCTCGC TCGGGTCAGC 60
CGCGGCCGGG GAGCCGGCGA CCGGAGCTGA GGCGGAGCCC GGCCCTCCGG CCCCGCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR012983--PHR
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF08005--PHR

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0005829--C:cytosol
GO:0000932--C:P-body
GO:0043234--C:protein complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0022008--P:neurogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

mmu:83962

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002337	Ailuropoda melanoleuca	97.97	0.00e+00	863.00
IUUC-Aca-004409	Anolis carolinensis	91.80	0.00e+00	834.00
IUUC-Bta-012943	Bos taurus	95.94	0.00e+00	856.00
IUUC-Cja-018932	Callithrix jacchus	98.41	0.00e+00	869.00
IUUC-Cpo-021442	Cavia porcellus	97.49	0.00e+00	856.00
IUUC-Csa-023065	Chlorocebus sabaeus	98.42	0.00e+00	875.00
IUUC-Cho-024988	Choloepus hoffmanni	97.42	4.00e-112	397.00
IUUC-Dno-029188	Dasypus novemcinctus	97.30	0.00e+00	858.00
IUUC-Gmo-039530	Gadus morhua	87.78	0.00e+00	764.00
IUUC-Gac-041292	Gasterosteus aculeatus	87.67	0.00e+00	788.00
IUUC-Ggo-044634	Gorilla gorilla	98.87	0.00e+00	871.00
IUUC-Hsa-046417	Homo sapiens	98.87	0.00e+00	871.00
IUUC-Itr-048421	Ictidomys tridecemlineatus	98.42	0.00e+00	873.00
IUUC-Loc-052236	Lepisosteus oculatus	89.44	0.00e+00	820.00
IUUC-Laf-054062	Loxodonta africana	97.97	0.00e+00	868.00
IUUC-Meu-056514	Macropus eugenii	76.91	0.00e+00	633.00
IUUC-Mmr-060924	Microcebus murinus	98.42	0.00e+00	867.00
IUUC-Mdo-062855	Monodelphis domestica	95.74	0.00e+00	858.00
IUUC-Ont-072535	Oreochromis niloticus	83.18	0.00e+00	721.00
IUUC-Ocu-074518	Oryctolagus cuniculus	98.12	0.00e+00	759.00
IUUC-Ola-087042	Oryzias latipes	86.13	0.00e+00	749.00
IUUC-Oga-088986	Otolemur garnettii	98.64	0.00e+00	872.00
IUUC-Ptr-091613	Pan troglodytes	98.87	0.00e+00	871.00
IUUC-Pan-092323	Papio anubis	98.65	0.00e+00	875.00
IUUC-Psi-094048	Pelodiscus sinensis	91.28	0.00e+00	828.00
IUUC-Pfo-097347	Poecilia formosa	87.19	0.00e+00	797.00
IUUC-Pab-098330	Pongo abelii	98.64	0.00e+00	870.00
IUUC-Pca-100420	Procavia capensis	98.38	3.00e-134	471.00
IUUC-Rno-105116	Rattus norvegicus	99.55	0.00e+00	890.00
IUUC-Ssc-115374	Sus scrofa	96.86	0.00e+00	861.00
IUUC-Tgu-117423	Taeniopygia guttata	91.29	0.00e+00	846.00
IUUC-Tru-118529	Takifugu rubripes	86.97	0.00e+00	803.00
IUUC-Tsy-118878	Tarsius syrichta	97.55	2.00e-129	455.00
IUUC-Tni-120187	Tetraodon nigroviridis	86.13	0.00e+00	781.00
IUUC-Vpa-130673	Vicugna pacos	96.26	0.00e+00	810.00
IUUC-Xtr-132188	Xenopus tropicalis	86.64	0.00e+00	807.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence