iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037322

Ensembl Protein ID

ENSFALP00000011893.1

UniProt Accession

U3KA39; U3KA39_FICAL

Genbank Protein ID

ENSFALP00000011893

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01020814

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000011392.1	ENSFALT00000011942.1	ENSFALP00000011893.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-110	369.2	775	1105

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l+e++++  ++ ++n++n  ++kge+++++  ++++lw ++ k++sp++++ +++k++ +f g
   Q: 775  TGLRNLGNTCYMNSILQCLCNAPHLAEYFNRnLYQADINRSNFLGHKGEVAEEFGVIMKALWAGQYKYISPKDFKITIGKINDQFAG 861
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeed...kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++ +ee++d   +s++ ++a+ k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 862  YSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDhldDSSAAEIAWHKHKQLNESIIVALFQGQFKSTVQCLTCHKRSRTFEAFM 948
           *********************8855555555544440114445555***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ +++++   +lq+cL+ f+kee+l+++n++yc++ck +++++kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 949  YLSLPLASSSKC---TLQECLRLFSKEEKLTDNNRFYCSHCKTRRDSSKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1030
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    k+Y+L++v +H+G+l++GHY+ay+kn +++ W++fdD++V+e++ ++v++   s aY+lfY+
   Q: 1031 EtLDLSQYVIGPKTS---LKRYNLFSVSNHYGGLDGGHYTAYCKNASKQrWFKFDDHEVSEISASSVKS---SAAYILFYT 1105
           ***********9988...69*************************88778*******************...********8 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MPAVASVPKE LYLSTSLKDL NKKTEVKPEK TSTKSYVQSA LKIFKAAEES RLDGDEEKAY 60
ILYMKYVAVY NLIRKRPDFK QQQDYFHSIL GPTNLKKALD EAEILSDSLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAATATTG ATAGAGACTT ATAAGAAGCA GTAACATCCT AGTAGAGACA TAAGTAACAA 60
TATTAACATG CCTGCTGTGG CATCTGTACC TAAGGAGCTG TACCTCTCTA CTTCATTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

fab:101814480

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	81.21	0.00e+00	920.00
IUUC-Apl-003226	Anas platyrhynchos	83.58	0.00e+00	989.00
IUUC-Aca-004936	Anolis carolinensis	65.61	0.00e+00	1304.00
IUUC-Ago-007959	Ashbya gossypii	35.26	8.00e-55	208.00
IUUC-Acl-008102	Aspergillus clavatus	31.04	1.00e-52	201.00
IUUC-Afl-008604	Aspergillus flavus	30.71	1.00e-51	197.00
IUUC-Ani-009291	Aspergillus nidulans	30.77	3.00e-52	200.00
IUUC-Aor-010098	Aspergillus oryzae	30.71	3.00e-51	196.00
IUUC-Ate-010585	Aspergillus terreus	31.22	9.00e-52	198.00
IUUC-Ame-010960	Astyanax mexicanus	78.33	4.00e-87	313.00
IUUC-Bta-013008	Bos taurus	78.61	0.00e+00	875.00
IUUC-Bol-015281	Brassica oleracea	38.51	2.00e-49	189.00
IUUC-Bra-017228	Brassica rapa	39.40	3.00e-51	195.00
IUUC-Cel-018482	Caenorhabditis elegans	34.40	5.00e-54	206.00
IUUC-Cja-019173	Callithrix jacchus	80.52	0.00e+00	918.00
IUUC-Cfa-021243	Canis familiaris	80.86	0.00e+00	916.00
IUUC-Cpo-021522	Cavia porcellus	68.29	0.00e+00	1384.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.64	5.00e-83	300.00
IUUC-Csa-023616	Chlorocebus sabaeus	80.34	0.00e+00	912.00
IUUC-Cho-024381	Choloepus hoffmanni	68.22	0.00e+00	738.00
IUUC-Cin-025287	Ciona intestinalis	49.87	1.00e-97	350.00
IUUC-Csv-026253	Ciona savignyi	49.63	7.00e-89	322.00
IUUC-Cne-026821	Cryptococcus neoformans	41.27	3.00e-77	283.00
IUUC-Dre-028440	Danio rerio	70.43	0.00e+00	721.00
IUUC-Dno-029039	Dasypus novemcinctus	80.52	0.00e+00	928.00
IUUC-Dor-031043	Dipodomys ordii	89.22	2.00e-124	440.00
IUUC-Dme-032089	Drosophila melanogaster	46.83	2.00e-84	306.00
IUUC-Ete-033040	Echinops telfairi	63.43	0.00e+00	1229.00
IUUC-Eca-033449	Equus caballus	79.83	0.00e+00	919.00
IUUC-Eeu-034693	Erinaceus europaeus	87.93	9.00e-119	421.00
IUUC-Fca-035794	Felis catus	88.21	0.00e+00	835.00
IUUC-Gmo-038584	Gadus morhua	62.43	0.00e+00	670.00
IUUC-Gga-041188	Gallus gallus	91.17	0.00e+00	1029.00
IUUC-Gac-041850	Gasterosteus aculeatus	75.15	0.00e+00	742.00
IUUC-Ggo-045565	Gorilla gorilla	80.69	0.00e+00	920.00
IUUC-Hsa-046438	Homo sapiens	80.69	0.00e+00	920.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	68.83	0.00e+00	1397.00
IUUC-Kpa-049321	Komagataella pastoris	33.51	3.00e-49	189.00
IUUC-Lch-050485	Latimeria chalumnae	83.44	0.00e+00	835.00
IUUC-Loc-052769	Lepisosteus oculatus	74.13	0.00e+00	773.00
IUUC-Laf-053432	Loxodonta africana	74.34	0.00e+00	871.00
IUUC-Mcc-055823	Macaca mulatta	80.34	0.00e+00	917.00
IUUC-Meu-056099	Macropus eugenii	92.19	9.00e-156	544.00
IUUC-Mla-059089	Melampsora laricipopulina	40.80	6.00e-73	269.00
IUUC-Mga-059739	Meleagris gallopavo	90.46	0.00e+00	1018.00
IUUC-Mvi-060559	Microbotryum violaceum	41.59	7.00e-79	288.00
IUUC-Mmr-061158	Microcebus murinus	68.19	0.00e+00	1400.00
IUUC-Mdo-061801	Monodelphis domestica	83.70	0.00e+00	916.00
IUUC-Mmu-063665	Mus musculus	65.64	0.00e+00	1348.00
IUUC-Mpu-066738	Mustela putorius furo	81.03	0.00e+00	918.00
IUUC-Mlu-067307	Myotis lucifugus	68.55	0.00e+00	1428.00
IUUC-Nle-069314	Nomascus leucogenys	80.34	0.00e+00	916.00
IUUC-Opr-070378	Ochotona princeps	69.16	2.00e-130	459.00
IUUC-Ont-071545	Oreochromis niloticus	77.03	0.00e+00	765.00
IUUC-Oan-073537	Ornithorhynchus anatinus	80.52	0.00e+00	910.00
IUUC-Ocu-074193	Oryctolagus cuniculus	67.95	0.00e+00	1400.00
IUUC-Ola-086622	Oryzias latipes	76.37	0.00e+00	743.00
IUUC-Oga-088271	Otolemur garnettii	78.97	0.00e+00	903.00
IUUC-Oar-090431	Ovis aries	78.61	0.00e+00	880.00
IUUC-Ptr-091339	Pan troglodytes	69.55	0.00e+00	1470.00
IUUC-Pan-092266	Papio anubis	86.75	3.00e-168	583.00
IUUC-Psi-093187	Pelodiscus sinensis	68.21	2.00e-168	586.00
IUUC-Pma-094626	Petromyzon marinus	56.28	1.00e-141	496.00
IUUC-Pfo-096463	Poecilia formosa	75.61	0.00e+00	758.00
IUUC-Pab-097645	Pongo abelii	80.69	0.00e+00	919.00
IUUC-Pva-103222	Pteropus vampyrus	87.67	0.00e+00	694.00
IUUC-Pgr-103408	Puccinia graminis	36.31	6.00e-55	209.00
IUUC-Ptt-103699	Puccinia triticina	45.80	7.00e-68	252.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.01	1.00e-53	205.00
IUUC-Rno-105510	Rattus norvegicus	65.49	0.00e+00	1366.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.54	4.00e-52	199.00
IUUC-Sha-106879	Sarcophilus harrisii	82.49	0.00e+00	909.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.49	9.00e-52	197.00
IUUC-Sar-113019	Sorex araneus	66.55	0.00e+00	1340.00
IUUC-Sre-115031	Sporisorium reilianum	37.05	2.00e-70	260.00
IUUC-Ssc-116334	Sus scrofa	68.68	0.00e+00	1404.00
IUUC-Tgu-117062	Taeniopygia guttata	96.55	0.00e+00	1104.00
IUUC-Tru-117908	Takifugu rubripes	76.64	0.00e+00	751.00
IUUC-Tsy-118867	Tarsius syrichta	73.10	0.00e+00	806.00
IUUC-Tni-120206	Tetraodon nigroviridis	75.40	0.00e+00	734.00
IUUC-Tme-127144	Tuber melanosporum	40.28	3.00e-80	293.00
IUUC-Tbe-127877	Tupaia belangeri	89.54	7.00e-76	278.00
IUUC-Ttr-128580	Tursiops truncatus	79.14	0.00e+00	890.00
IUUC-Uma-129340	Ustilago maydis	37.85	4.00e-73	270.00
IUUC-Vpa-130541	Vicugna pacos	68.48	0.00e+00	1397.00
IUUC-Xtr-132161	Xenopus tropicalis	77.15	0.00e+00	802.00
IUUC-Xma-134271	Xiphophorus maculatus	74.80	0.00e+00	751.00
IUUC-Yli-134561	Yarrowia lipolytica	36.17	9.00e-62	231.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence