iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132161

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-specific peptidase 8

Genbank Nucleotide ID

AAMC01095050

Gene Name

usp8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000016117.3	ENSXETT00000035150.3	ENSXETP00000035150.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-109	365.5	757	1088

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n+p l e++++  ++ ++n++n  ++kge+++++  ++++lw+++ k++sp++++ +++k++e+f g
   Q: 757  TGLRNLGNTCYMNSILQCLCNTPHLIEYFNNnFYQAHINRSNLLGHKGEVAEEFGCIMRALWTGQYKYISPKDFKITIGKINEQFAG 843
           7******************************6678899************************************************* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedk...selsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y +qD+qE+l fl+d+l+e+l+k +n ++++ee++d+   s++ d+a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 844  YTHQDSQELLLFLMDGLHEDLNKADNRKRQKEENNDHlsdSQAADSAWYKHKQLNESIIVALFQGQFKSTVQCLTCQKKSRTFEAFM 930
           *********************9977766666666654111455556***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+p+ +++   slqdc+++f+kee+l+++n++ c++ck ++ a+kk++++klP++L +hLkR sfs e+  r+k++++v+fpl
   Q: 931  YLSLPLPSTSKC---SLQDCIKAFAKEEKLTDSNRFDCSNCKTQRVATKKIEIWKLPPILLVHLKRKSFSFEGRWRQKLQSYVDFPL 1014
           ***********9...************************************************************************ PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p++     k+Y+L++v +H+G+l++GHY+ay+kn  ++ W++fdD+ V+e++ ++v++   s aY+lfY+
   Q: 1015 EsLDLSQYVIGPKN----VKTYNLFGVSNHYGGLDGGHYTAYCKNALKQrWFKFDDHDVSEISVSSVKT---SAAYMLFYT 1088
           ***********885....68*************************66656*******************...********8 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MPTVSALPKE LYLSSSLSDL KKKAEVKPDK TSTKSYVSSA CKIFQKAEEC RLEGDEEKAY 60
VFYMKYLFVF ELLKKRSDFK QNQDYYKSLL GPSTILKSVE EAEKLSESLK NRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCTGGT GAACTCAGCA GTGATGTACA TTGCTCCTTC ACTTTCAAAC ATGCTGAGTT 60
AAGAGGAGAA CTTCTGCTGT ACAGTGAGTA ACTCCCCCCT CAGTCTTCTC AAGCATACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007330--MIT
IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0031313--C:extrinsic component of endosome membrane
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	68.82	0.00e+00	781.00
IUUC-Apl-003226	Anas platyrhynchos	59.41	0.00e+00	1166.00
IUUC-Aca-004936	Anolis carolinensis	55.73	0.00e+00	1041.00
IUUC-Ago-007959	Ashbya gossypii	36.51	2.00e-58	221.00
IUUC-Acl-008102	Aspergillus clavatus	31.54	1.00e-53	204.00
IUUC-Afl-008604	Aspergillus flavus	30.73	4.00e-54	206.00
IUUC-Afu-009001	Aspergillus fumigatus	32.15	7.00e-55	209.00
IUUC-Ani-009291	Aspergillus nidulans	31.00	2.00e-53	204.00
IUUC-Ang-009844	Aspergillus niger	31.88	9.00e-54	205.00
IUUC-Aor-010098	Aspergillus oryzae	30.73	2.00e-53	204.00
IUUC-Ate-010585	Aspergillus terreus	31.44	3.00e-53	203.00
IUUC-Ame-010960	Astyanax mexicanus	73.89	2.00e-79	288.00
IUUC-Bta-013008	Bos taurus	76.05	0.00e+00	772.00
IUUC-Bol-015281	Brassica oleracea	38.39	8.00e-49	187.00
IUUC-Bra-017228	Brassica rapa	38.33	2.00e-50	192.00
IUUC-Cel-018482	Caenorhabditis elegans	33.24	2.00e-55	210.00
IUUC-Cja-019173	Callithrix jacchus	68.82	0.00e+00	782.00
IUUC-Cfa-021243	Canis familiaris	68.29	0.00e+00	786.00
IUUC-Cpo-021522	Cavia porcellus	57.65	0.00e+00	1142.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	43.23	7.00e-83	300.00
IUUC-Csa-023616	Chlorocebus sabaeus	68.65	0.00e+00	776.00
IUUC-Cho-024381	Choloepus hoffmanni	70.18	0.00e+00	655.00
IUUC-Cin-025287	Ciona intestinalis	50.00	7.00e-98	352.00
IUUC-Csv-026253	Ciona savignyi	48.03	2.00e-87	317.00
IUUC-Cne-026821	Cryptococcus neoformans	38.67	2.00e-73	271.00
IUUC-Dre-028440	Danio rerio	68.34	0.00e+00	711.00
IUUC-Dno-029039	Dasypus novemcinctus	70.83	0.00e+00	792.00
IUUC-Dor-031043	Dipodomys ordii	77.25	2.00e-110	394.00
IUUC-Dse-031463	Dothistroma septosporum	28.18	1.00e-44	174.00
IUUC-Dme-032089	Drosophila melanogaster	43.90	4.00e-86	312.00
IUUC-Ete-033040	Echinops telfairi	54.09	0.00e+00	972.00
IUUC-Eca-033449	Equus caballus	68.82	0.00e+00	803.00
IUUC-Eeu-034693	Erinaceus europaeus	77.68	3.00e-104	373.00
IUUC-Fca-035794	Felis catus	77.73	0.00e+00	742.00
IUUC-Fal-037322	Ficedula albicollis	76.55	0.00e+00	773.00
IUUC-Gmo-038584	Gadus morhua	63.25	0.00e+00	637.00
IUUC-Gga-041188	Gallus gallus	76.55	0.00e+00	768.00
IUUC-Gac-041850	Gasterosteus aculeatus	69.03	0.00e+00	702.00
IUUC-Ggo-045565	Gorilla gorilla	68.82	0.00e+00	783.00
IUUC-Hsa-046438	Homo sapiens	68.82	0.00e+00	783.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	57.70	0.00e+00	1141.00
IUUC-Kpa-049321	Komagataella pastoris	33.97	5.00e-53	202.00
IUUC-Lch-050485	Latimeria chalumnae	76.33	0.00e+00	778.00
IUUC-Loc-052769	Lepisosteus oculatus	74.53	0.00e+00	739.00
IUUC-Lma-053021	Leptosphaeria maculans	31.37	8.00e-53	202.00
IUUC-Laf-053432	Loxodonta africana	57.63	0.00e+00	1128.00
IUUC-Mcc-055823	Macaca mulatta	68.65	0.00e+00	781.00
IUUC-Meu-056099	Macropus eugenii	83.76	7.00e-140	491.00
IUUC-Mla-059089	Melampsora laricipopulina	41.46	7.00e-74	272.00
IUUC-Mga-059739	Meleagris gallopavo	76.75	0.00e+00	767.00
IUUC-Mvi-060559	Microbotryum violaceum	40.56	8.00e-78	285.00
IUUC-Mmr-061158	Microcebus murinus	68.77	0.00e+00	778.00
IUUC-Mdo-061801	Monodelphis domestica	73.91	0.00e+00	778.00
IUUC-Mmu-063665	Mus musculus	75.30	0.00e+00	768.00
IUUC-Mpu-066738	Mustela putorius furo	69.17	0.00e+00	783.00
IUUC-Mlu-067307	Myotis lucifugus	69.44	0.00e+00	802.00
IUUC-Nfi-068410	Neosartorya fischeri	31.88	8.00e-55	209.00
IUUC-Nle-069314	Nomascus leucogenys	68.82	0.00e+00	784.00
IUUC-Opr-070378	Ochotona princeps	76.95	8.00e-113	401.00
IUUC-Ont-071545	Oreochromis niloticus	70.30	0.00e+00	706.00
IUUC-Oan-073537	Ornithorhynchus anatinus	76.65	0.00e+00	774.00
IUUC-Ocu-074193	Oryctolagus cuniculus	58.76	0.00e+00	1160.00
IUUC-Ola-086622	Oryzias latipes	69.05	0.00e+00	688.00
IUUC-Oga-088271	Otolemur garnettii	68.92	0.00e+00	775.00
IUUC-Oar-090431	Ovis aries	68.99	0.00e+00	775.00
IUUC-Ptr-091339	Pan troglodytes	59.67	0.00e+00	1208.00
IUUC-Pan-092266	Papio anubis	78.14	1.00e-150	525.00
IUUC-Psi-093187	Pelodiscus sinensis	75.77	5.00e-116	411.00
IUUC-Pma-094626	Petromyzon marinus	54.99	3.00e-139	488.00
IUUC-Pfo-096463	Poecilia formosa	69.90	0.00e+00	702.00
IUUC-Pab-097645	Pongo abelii	68.82	0.00e+00	783.00
IUUC-Pva-103222	Pteropus vampyrus	77.81	9.00e-179	620.00
IUUC-Pgr-103408	Puccinia graminis	36.66	2.00e-58	221.00
IUUC-Ptt-103699	Puccinia triticina	46.88	1.00e-69	258.00
IUUC-Pte-104348	Pyrenophora teres	28.14	2.00e-39	157.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.10	5.00e-51	196.00
IUUC-Rno-105510	Rattus norvegicus	76.33	0.00e+00	775.00
IUUC-Sce-106166	Saccharomyces cerevisiae	34.79	7.00e-53	202.00
IUUC-Sha-106879	Sarcophilus harrisii	73.68	0.00e+00	776.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	34.44	1.00e-49	190.00
IUUC-Sar-113019	Sorex araneus	55.71	0.00e+00	1080.00
IUUC-Sre-115031	Sporisorium reilianum	37.95	1.00e-71	265.00
IUUC-Ssc-116334	Sus scrofa	58.40	0.00e+00	1151.00
IUUC-Tgu-117062	Taeniopygia guttata	76.35	0.00e+00	771.00
IUUC-Tru-117908	Takifugu rubripes	70.47	0.00e+00	699.00
IUUC-Tsy-118867	Tarsius syrichta	61.50	0.00e+00	673.00
IUUC-Tni-120206	Tetraodon nigroviridis	53.21	0.00e+00	1016.00
IUUC-Tme-127144	Tuber melanosporum	40.37	7.00e-82	298.00
IUUC-Tbe-127877	Tupaia belangeri	74.68	2.00e-63	237.00
IUUC-Ttr-128580	Tursiops truncatus	67.97	0.00e+00	771.00
IUUC-Uma-129340	Ustilago maydis	35.02	1.00e-72	268.00
IUUC-Vpa-130541	Vicugna pacos	67.97	0.00e+00	763.00
IUUC-Xma-134271	Xiphophorus maculatus	69.70	0.00e+00	699.00
IUUC-Yli-134561	Yarrowia lipolytica	35.56	9.00e-59	221.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence