iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000000338.3	ENSMMUT00000000496.3	ENSMMUP00000000460.2
ENSMMUG00000000338.3	ENSMMUT00000000495.3	ENSMMUP00000000459.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.20e-09	38.2	15	60
E3 activity/RING/U-box	3.30e-07	31.4	9	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ C+  k++ +   s++e +CP+C+
   Q: 15   CPICLELLTE-PLSLDCGHSFCQACItAKIKESVTISRGESSCPVCQ 60
           ********99.***************7555888899**********7 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk......tcPvtrqplteedlvPnltlrrliq 66
           + +e  CpI lel ++P  l +G+++ +++I   ++++ +      +cPv+++++++ +l Pn  l ++++
   Q: 9    IEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVTisrgesSCPVCQSRFQPGKLRPNRHLANIVE 79
           567899***************************9966666666666******************9988776 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MDFSVKVDIE KEVTCPICLE LLTEPLSLDC GHSFCQACIT AKIKESVTIS RGESSCPVCQ 60
SRFQPGKLRP NRHLANIVER VKEVKMSPQE GQKRDICEHH GKKLQIFCKE DGKVICWVCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTATTATTC TCTGGAATCC ATCCTCATCT GGCCTGTCTG GATTAGGAGC AGGAAGTGAT 60
AATTAACTGA TGGACTTTTA AGATTTAATG ACATTTTGAG AACATTTTTT TCAATGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0016874--F:ligase activity
GO:0008270--F:zinc ion binding
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070206--P:protein trimerization
GO:0032880--P:regulation of protein localization

KEGG

mcc:713814

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002371	Ailuropoda melanoleuca	66.67	0.00e+00	692.00
IUUC-Acl-008013	Aspergillus clavatus	58.82	2.00e-06	48.10
IUUC-Ani-009293	Aspergillus nidulans	60.61	5.00e-06	47.00
IUUC-Cfa-021080	Canis familiaris	66.27	0.00e+00	682.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	33.75	2.00e-09	57.00
IUUC-Csa-023785	Chlorocebus sabaeus	94.58	0.00e+00	956.00
IUUC-Eeu-034968	Erinaceus europaeus	49.78	2.00e-116	412.00
IUUC-Ggo-044550	Gorilla gorilla	91.16	0.00e+00	887.00
IUUC-Hsa-046363	Homo sapiens	91.57	0.00e+00	926.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	53.86	2.00e-139	488.00
IUUC-Laf-053647	Loxodonta africana	64.86	0.00e+00	634.00
IUUC-Mpu-066674	Mustela putorius furo	65.46	0.00e+00	681.00
IUUC-Nle-068980	Nomascus leucogenys	92.37	0.00e+00	929.00
IUUC-Oga-088267	Otolemur garnettii	55.76	7.00e-147	513.00
IUUC-Ptr-091300	Pan troglodytes	90.96	0.00e+00	915.00
IUUC-Pan-092605	Papio anubis	88.96	0.00e+00	864.00
IUUC-Pab-098535	Pongo abelii	91.77	0.00e+00	925.00
IUUC-Rno-105401	Rattus norvegicus	55.22	7.00e-148	516.00
IUUC-Ssc-115715	Sus scrofa	55.31	4.00e-146	511.00
IUUC-Tsy-119330	Tarsius syrichta	75.70	0.00e+00	739.00
IUUC-Tur-126362	Triticum urartu	37.88	2.00e-07	50.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence