iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000072244.11	ENSMUST00000098180.9	ENSMUSP00000095782.3
ENSMUSG00000072244.11	ENSMUST00000214578.1	ENSMUSP00000149805.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.10e-08	34.0	15	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle + + pl+ +CgH f++ C+  + +++   + ++ +CP+Cr
   Q: 15   CPICLELLTE-PLSIDCGHSFCQVCIiGNSNNSVFGQGGRSSCPVCR 60
           ********99.**************973335677999*********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218).

Protein Sequence
(Fasta)

MTSTVLVDIR DEVTCPICLE LLTEPLSIDC GHSFCQVCII GNSNNSVFGQ GGRSSCPVCR 60
TSYQPGNLRP NRHLAAIVKR LREVALCPGK QLEVIFCALH GEKLQLFCKE DGKLICWLCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTTTTCCT GGAGTCCGGC TTTAGTACTG GAAGGAGCCG TCTCCTTGGC TGCAAGTCCT 60
CGGCACTGAT CCAGGCACGG ATTCCAGATT GGTGAGCAAA CCCATTTTCT GACCAGTCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR010908--Longin_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0030674--F:protein binding, bridging
GO:0019901--F:protein kinase binding
GO:1990782--F:protein tyrosine kinase binding
GO:0008134--F:transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035458--P:cellular response to interferon-beta
GO:0098586--P:cellular response to virus
GO:0010994--P:free ubiquitin chain polymerization
GO:0010629--P:negative regulation of gene expression
GO:2000737--P:negative regulation of stem cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045071--P:negative regulation of viral genome replication
GO:0002741--P:positive regulation of cytokine secretion involved in immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010628--P:positive regulation of gene expression
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0032496--P:response to lipopolysaccharide

KEGG

mmu:94088

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001965	Ailuropoda melanoleuca	77.66	0.00e+00	753.00
IUUC-Bta-013110	Bos taurus	52.61	3.00e-146	511.00
IUUC-Cel-018621	Caenorhabditis elegans	28.18	7.00e-10	58.50
IUUC-Cja-019944	Callithrix jacchus	51.72	2.00e-131	462.00
IUUC-Csa-023785	Chlorocebus sabaeus	56.02	1.00e-150	526.00
IUUC-Cho-024416	Choloepus hoffmanni	58.37	2.00e-86	312.00
IUUC-Dno-029492	Dasypus novemcinctus	53.75	3.00e-147	516.00
IUUC-Dor-030480	Dipodomys ordii	77.00	6.00e-129	454.00
IUUC-Ete-033021	Echinops telfairi	47.07	5.00e-106	377.00
IUUC-Eca-034235	Equus caballus	54.91	1.00e-146	513.00
IUUC-Eeu-034968	Erinaceus europaeus	48.05	5.00e-104	371.00
IUUC-Fca-035533	Felis catus	78.07	0.00e+00	759.00
IUUC-Hsa-046006	Homo sapiens	80.12	0.00e+00	810.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	80.38	0.00e+00	768.00
IUUC-Laf-053805	Loxodonta africana	76.64	0.00e+00	701.00
IUUC-Mmr-061023	Microcebus murinus	78.35	0.00e+00	735.00
IUUC-Mpu-065842	Mustela putorius furo	78.03	0.00e+00	756.00
IUUC-Mlu-067695	Myotis lucifugus	53.74	3.00e-135	474.00
IUUC-Opr-071057	Ochotona princeps	50.31	1.00e-118	419.00
IUUC-Oru-085144	Oryza rufipogon	44.44	6.00e-08	52.00
IUUC-Oga-088267	Otolemur garnettii	78.81	0.00e+00	767.00
IUUC-Ptr-090573	Pan troglodytes	80.33	0.00e+00	812.00
IUUC-Pan-092745	Papio anubis	80.33	0.00e+00	797.00
IUUC-Rno-105401	Rattus norvegicus	93.65	0.00e+00	914.00
IUUC-Sar-113094	Sorex araneus	47.66	3.00e-105	375.00
IUUC-Ssc-115715	Sus scrofa	53.44	2.00e-136	479.00
IUUC-Tur-126362	Triticum urartu	45.28	8.00e-08	51.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence