iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046837

UUCD1 version

UUC-HoS-00324

Ensembl Protein ID

ENSP00000351539.4

UniProt Accession

Q99592; A8K5U3; Q13397; Q5VU40; Q8N463; Q9UD99; ZBT18_HUMAN

Genbank Protein ID

AAA81368.1; CAA64468.1; CAA04718.1; CAA11262.1; BAF84097.1; CAH71954.2; AAH36677.2

Protein Name

Zinc finger and BTB domain-containing protein 18; 58 kDa repressor protein; Transcriptional repressor RP58; Translin-associated zinc finger protein 1; Zinc finger protein 238; Zinc finger protein C2H2-171

Genbank Nucleotide ID

U38896; X95072; AJ001388; AJ223321; AK291408; AL590483; BC036677

Gene Name

ZBTB18; RP58; TAZ1; ZNF238

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000179456.10	ENST00000358704.4	ENSP00000351539.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	JASPAR	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	21474562

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.60e-12	48.6	33	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklden 68
           +D+++ vg+ +f+ah++vLa++S +F+   + +l+++   + v+++ d v + +f  ll+F+Y gkl+ +
   Q: 33   CDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR---DIVHLNsDiVTAPAFALLLEFMYEGKLQFK 99
           8*************************98777777765...6*****99*******************865 PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.

Protein Sequence
(Fasta)

MCPKGYEDSM EFPDHSRHLL QCLSEQRHQG FLCDCTVLVG DAQFRAHRAV LASCSMYFHL 60
FYKDQLDKRD IVHLNSDIVT APAFALLLEF MYEGKLQFKD LPIEDVLAAA SYLHMYDIVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGGCGG AGGACGCGGC GGCGGCGGGG ACGCGGTGAC TTAGGGCCGC TCCGTGTGAG 60
TCCCGGCGCC GGCCCCTGGC CCCTGACCTG GCGCCCCCTC CGCGCCCCGG CACCCCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton
GO:0000228--C:nuclear chromosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007519--P:skeletal muscle tissue development
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:10472

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002255	Ailuropoda melanoleuca	92.98	0.00e+00	900.00
IUUC-Apl-004085	Anas platyrhynchos	97.51	0.00e+00	990.00
IUUC-Aca-005205	Anolis carolinensis	96.55	0.00e+00	989.00
IUUC-Ame-011717	Astyanax mexicanus	71.27	0.00e+00	711.00
IUUC-Bta-013254	Bos taurus	99.25	0.00e+00	1058.00
IUUC-Cja-019019	Callithrix jacchus	99.44	0.00e+00	1029.00
IUUC-Cfa-020089	Canis familiaris	94.98	0.00e+00	897.00
IUUC-Cpo-022313	Cavia porcellus	93.97	0.00e+00	977.00
IUUC-Csa-023163	Chlorocebus sabaeus	73.78	0.00e+00	643.00
IUUC-Dre-028629	Danio rerio	71.74	0.00e+00	690.00
IUUC-Dno-029978	Dasypus novemcinctus	93.98	0.00e+00	949.00
IUUC-Dor-031076	Dipodomys ordii	94.87	0.00e+00	931.00
IUUC-Eca-034186	Equus caballus	98.49	0.00e+00	1052.00
IUUC-Eeu-035053	Erinaceus europaeus	99.06	0.00e+00	1056.00
IUUC-Fca-036534	Felis catus	92.16	8.00e-115	406.00
IUUC-Fal-036841	Ficedula albicollis	96.80	0.00e+00	1006.00
IUUC-Gmo-039206	Gadus morhua	83.94	7.00e-97	348.00
IUUC-Gga-040558	Gallus gallus	97.36	0.00e+00	1006.00
IUUC-Gac-042192	Gasterosteus aculeatus	65.16	0.00e+00	637.00
IUUC-Ggo-045056	Gorilla gorilla	99.81	0.00e+00	1063.00
IUUC-Itr-048183	Ictidomys tridecemlineatus	99.62	0.00e+00	1036.00
IUUC-Lch-050214	Latimeria chalumnae	86.29	0.00e+00	852.00
IUUC-Loc-051869	Lepisosteus oculatus	74.64	0.00e+00	691.00
IUUC-Laf-053454	Loxodonta africana	98.67	0.00e+00	1042.00
IUUC-Mcc-055511	Macaca mulatta	99.55	0.00e+00	865.00
IUUC-Meu-056846	Macropus eugenii	97.18	0.00e+00	1035.00
IUUC-Mga-059766	Meleagris gallopavo	95.40	0.00e+00	954.00
IUUC-Mmr-061689	Microcebus murinus	98.68	0.00e+00	1045.00
IUUC-Mdo-062846	Monodelphis domestica	97.51	0.00e+00	1024.00
IUUC-Mmu-063612	Mus musculus	99.44	0.00e+00	1060.00
IUUC-Mpu-066244	Mustela putorius furo	80.41	0.00e+00	825.00
IUUC-Mlu-067913	Myotis lucifugus	96.74	0.00e+00	990.00
IUUC-Nle-068967	Nomascus leucogenys	99.25	0.00e+00	1052.00
IUUC-Ont-072037	Oreochromis niloticus	59.66	2.00e-174	605.00
IUUC-Oan-072812	Ornithorhynchus anatinus	87.60	2.00e-137	483.00
IUUC-Ocu-073991	Oryctolagus cuniculus	99.62	0.00e+00	1056.00
IUUC-Ola-086871	Oryzias latipes	65.60	0.00e+00	632.00
IUUC-Oga-089062	Otolemur garnettii	99.23	0.00e+00	1036.00
IUUC-Oar-089345	Ovis aries	92.17	0.00e+00	892.00
IUUC-Ptr-091144	Pan troglodytes	99.81	0.00e+00	1063.00
IUUC-Pan-091848	Papio anubis	99.81	0.00e+00	1063.00
IUUC-Psi-093729	Pelodiscus sinensis	55.27	1.00e-125	443.00
IUUC-Pfo-097013	Poecilia formosa	62.37	0.00e+00	631.00
IUUC-Pab-097678	Pongo abelii	99.43	0.00e+00	1053.00
IUUC-Pva-102751	Pteropus vampyrus	98.68	0.00e+00	1052.00
IUUC-Rno-105901	Rattus norvegicus	99.23	0.00e+00	1039.00
IUUC-Sha-106850	Sarcophilus harrisii	97.51	0.00e+00	1024.00
IUUC-Sar-112964	Sorex araneus	99.06	0.00e+00	1058.00
IUUC-Ssc-115395	Sus scrofa	98.47	0.00e+00	1032.00
IUUC-Tgu-117216	Taeniopygia guttata	96.93	0.00e+00	988.00
IUUC-Tru-117749	Takifugu rubripes	54.70	3.00e-127	449.00
IUUC-Tsy-118841	Tarsius syrichta	97.93	0.00e+00	1046.00
IUUC-Tni-120035	Tetraodon nigroviridis	66.25	0.00e+00	643.00
IUUC-Ttr-128943	Tursiops truncatus	98.38	0.00e+00	630.00
IUUC-Xtr-131820	Xenopus tropicalis	87.55	0.00e+00	893.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence