iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073054

UUCD1 version

UUC-OrA-00862

Ensembl Protein ID

ENSOANP00000003838.1

UniProt Accession

F7AIJ4; F7AIJ4_ORNAN

Protein Name

Uncharacterized protein

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000002421.2	ENSOANT00000003839.2	ENSOANP00000003838.1
ENSOANG00000002421.2	ENSOANT00000003840.2	ENSOANP00000003839.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-58	198.8	170	647

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+   +  ++l+++++++++ +++++l+ lf+ l+ sk+k+v+p++ +++lk++ ++ + 
   Q: 170  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNynlSSAQDLPRNQKEHRNLPFMRELRYLFALLVGSKRKYVDPSRAVDILKDAFKS-ND 257
           6******************************99999999999999999*********************************99997.9* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           ++qqD++Ef++ lld le++++                   + +ee++ +k k+++++lF g++    + +    ++s+  +  +l+l+
   Q: 258  SQQQDVSEFTHRLLDWLEDAFQ------------------IKAEEERDGEKPKNPMVELFYGRFLAVGVLEGQSYNNSKIGS--SLELK 326
           *********************2..................22345678999**************99999887777777765..77778 PP
   S: 176  vpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           + +k+++     ++cL   + +  l++++k      ++ +++  ++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l+++
   Q: 327  IWNKKKS-----RECLTISSLTPDLREKEK-----ARA-SRSWSEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRY 404
           8888855.....99**98888888886443.....333.3356789******************************************* PP
   S: 265  cts...................................................................................pee 270
           +++                                                                                   +  
   Q: 405  MHKnreitrikreeikrlkeyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvedidaaapssgsqtspsstteQ-- 491
           ***888888888888888888888888888888888888888888888888888777777777777777777776666666555550.. PP
   S: 271  kqke..................................................................................... 274
              +                                                                                     
   Q: 492  ---Qgapsseipstsptprsvihkpftqsrippdlpmhpaprhiteeelavlegclhrwrtevendtrdlqesiarihrtielmysdks 577
           ...05555556666666666666666666666666666666666666777777777777777777777788888888888888888888 PP
   S: 275  ..kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
             +  Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D +Vt++++ee ++++      ++aY+l+Y 
   Q: 578  miQFPYRLHAVLVHEGQANAGHYWAYIFDHHHErWMKYNDISVTKSTWEELERDSFggyrnASAYCLMYI 647
           88***************************87778*******************8779************6 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

LGVEQMTQKW MRSRNQHQQT FLNQLREITG INDIQILQQA LKDSKGNLEL AVAFLTAKNA 60
KAPQQEETTY YQTALPNNDR YISVGSQADT NVIDLTGDDK DDLQRAIALS LEESNRAFRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGGGGTCG AACAGATGAC CCAGAAGTGG ATGAGGAGCA GGAATCAGGT TTATAATTCC 60
CAAACAAAGC CTCCATTGCA GCTGGGAGGG AATCTTACCC CCGGCCTCCG CCCTCCCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	83.43	0.00e+00	1778.00
IUUC-Apl-004030	Anas platyrhynchos	84.06	0.00e+00	1842.00
IUUC-Aca-004753	Anolis carolinensis	64.47	0.00e+00	1014.00
IUUC-Ago-007865	Ashbya gossypii	38.96	5.00e-08	53.50
IUUC-Acl-008164	Aspergillus clavatus	34.95	1.00e-09	58.90
IUUC-Afu-008871	Aspergillus fumigatus	23.50	6.00e-10	59.70
IUUC-Ani-009503	Aspergillus nidulans	33.64	2.00e-10	61.20
IUUC-Ang-009577	Aspergillus niger	44.12	4.00e-10	60.10
IUUC-Ate-010275	Aspergillus terreus	28.80	1.00e-10	62.00
IUUC-Ame-010624	Astyanax mexicanus	70.83	0.00e+00	1095.00
IUUC-Bgr-011993	Blumeria graminis	35.14	7.00e-11	62.80
IUUC-Bta-013166	Bos taurus	81.19	0.00e+00	1692.00
IUUC-Cel-018346	Caenorhabditis elegans	29.08	6.00e-26	112.00
IUUC-Cja-019150	Callithrix jacchus	80.16	0.00e+00	1742.00
IUUC-Cfa-020649	Canis familiaris	80.40	0.00e+00	1756.00
IUUC-Cpo-021807	Cavia porcellus	82.98	0.00e+00	1840.00
IUUC-Csa-023388	Chlorocebus sabaeus	80.23	0.00e+00	1768.00
IUUC-Cho-024343	Choloepus hoffmanni	68.81	0.00e+00	894.00
IUUC-Cin-025302	Ciona intestinalis	36.47	5.00e-89	321.00
IUUC-Csv-025911	Ciona savignyi	34.65	1.00e-130	459.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	53.33	1.00e-09	58.50
IUUC-Cme-027167	Cyanidioschyzon merolae	31.50	1.00e-13	71.60
IUUC-Dre-028016	Danio rerio	68.84	0.00e+00	1509.00
IUUC-Dno-029495	Dasypus novemcinctus	77.63	0.00e+00	1737.00
IUUC-Dor-030948	Dipodomys ordii	71.46	0.00e+00	1272.00
IUUC-Ete-032828	Echinops telfairi	42.99	1.00e-168	587.00
IUUC-Eca-034300	Equus caballus	49.07	0.00e+00	954.00
IUUC-Eeu-034458	Erinaceus europaeus	48.43	0.00e+00	858.00
IUUC-Fca-035876	Felis catus	81.17	0.00e+00	1712.00
IUUC-Fal-036762	Ficedula albicollis	80.37	0.00e+00	1031.00
IUUC-Fox-037752	Fusarium oxysporum	23.70	1.00e-15	78.60
IUUC-Fso-038114	Fusarium solani	34.26	3.00e-11	64.30
IUUC-Gmo-039490	Gadus morhua	70.56	0.00e+00	1509.00
IUUC-Gga-040817	Gallus gallus	81.48	0.00e+00	1822.00
IUUC-Gac-042473	Gasterosteus aculeatus	71.39	0.00e+00	1540.00
IUUC-Ggo-044939	Gorilla gorilla	81.60	0.00e+00	1721.00
IUUC-Hsa-046204	Homo sapiens	80.58	0.00e+00	1684.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	44.31	4.00e-162	563.00
IUUC-Kpa-049349	Komagataella pastoris	29.32	2.00e-09	57.80
IUUC-Lch-049572	Latimeria chalumnae	74.84	0.00e+00	1638.00
IUUC-Loc-052070	Lepisosteus oculatus	73.28	0.00e+00	1595.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	2.00e-11	64.70
IUUC-Laf-054426	Loxodonta africana	79.52	0.00e+00	1577.00
IUUC-Mcc-055858	Macaca mulatta	80.25	0.00e+00	1771.00
IUUC-Meu-056416	Macropus eugenii	47.17	5.00e-171	594.00
IUUC-Mga-059808	Meleagris gallopavo	81.72	0.00e+00	1756.00
IUUC-Mmr-060987	Microcebus murinus	81.03	0.00e+00	1761.00
IUUC-Mdo-061955	Monodelphis domestica	51.39	0.00e+00	664.00
IUUC-Mmu-064245	Mus musculus	78.72	0.00e+00	1696.00
IUUC-Mpu-066304	Mustela putorius furo	80.00	0.00e+00	1748.00
IUUC-Mlu-067139	Myotis lucifugus	80.26	0.00e+00	1734.00
IUUC-Nfi-068458	Neosartorya fischeri	24.17	2.00e-14	74.70
IUUC-Nle-069075	Nomascus leucogenys	80.30	0.00e+00	1674.00
IUUC-Opr-070888	Ochotona princeps	54.31	2.00e-83	303.00
IUUC-Ont-072150	Oreochromis niloticus	68.16	0.00e+00	1534.00
IUUC-Ocu-074102	Oryctolagus cuniculus	78.35	0.00e+00	1744.00
IUUC-Ola-086529	Oryzias latipes	68.19	0.00e+00	1470.00
IUUC-Oga-088939	Otolemur garnettii	80.09	0.00e+00	1702.00
IUUC-Oar-090266	Ovis aries	80.95	0.00e+00	1760.00
IUUC-Ptr-090546	Pan troglodytes	80.39	0.00e+00	1681.00
IUUC-Pan-092311	Papio anubis	80.16	0.00e+00	1770.00
IUUC-Psi-093459	Pelodiscus sinensis	86.41	0.00e+00	1094.00
IUUC-Pma-094250	Petromyzon marinus	44.15	5.00e-62	230.00
IUUC-Pno-095093	Phaeosphaeria nodorum	39.51	2.00e-11	64.30
IUUC-Pfo-096726	Poecilia formosa	65.11	0.00e+00	1456.00
IUUC-Pab-097608	Pongo abelii	83.26	0.00e+00	1764.00
IUUC-Pca-100718	Procavia capensis	72.37	0.00e+00	1214.00
IUUC-Pva-103150	Pteropus vampyrus	79.73	0.00e+00	1318.00
IUUC-Rno-105727	Rattus norvegicus	79.09	0.00e+00	1674.00
IUUC-Sha-107051	Sarcophilus harrisii	83.15	0.00e+00	1762.00
IUUC-Sja-107936	Schizosaccharomyces japonicus	41.67	2.00e-10	61.20
IUUC-Spo-108381	Schizosaccharomyces pombe	46.43	4.00e-11	63.50
IUUC-Ssl-108532	Sclerotinia sclerotiorum	29.10	6.00e-11	63.20
IUUC-Sar-113097	Sorex araneus	76.82	0.00e+00	1635.00
IUUC-Ssc-115877	Sus scrofa	78.06	0.00e+00	1682.00
IUUC-Tgu-117473	Taeniopygia guttata	77.30	0.00e+00	1642.00
IUUC-Tru-118135	Takifugu rubripes	64.41	0.00e+00	1325.00
IUUC-Tsy-119471	Tarsius syrichta	78.74	0.00e+00	1593.00
IUUC-Tni-120139	Tetraodon nigroviridis	70.73	0.00e+00	910.00
IUUC-Tme-126928	Tuber melanosporum	35.00	5.00e-10	60.10
IUUC-Tbe-127549	Tupaia belangeri	77.09	0.00e+00	1619.00
IUUC-Ttr-128896	Tursiops truncatus	79.44	0.00e+00	1694.00
IUUC-Vda-129742	Verticillium dahliae	23.94	8.00e-11	62.80
IUUC-Vpa-130500	Vicugna pacos	77.37	0.00e+00	1657.00
IUUC-Xtr-132896	Xenopus tropicalis	76.33	0.00e+00	1647.00
IUUC-Xma-133349	Xiphophorus maculatus	69.42	0.00e+00	1500.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence