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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063326
UUCD1 version UUC-MuM-00444
Ensembl Protein ID ENSMUSP00000074594.4
UniProt Accession Q5NCC9; TRI58_MOUSE
Genbank Protein ID CAI24038.1
Protein Name E3 ubiquitin-protein ligase TRIM58; RING-type E3 ubiquitin transferase TRIM58; Tripartite motif-containing protein 58
Genbank Nucleotide ID AL645802
Gene Name Trim58; Gm16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000037124.6 ENSMUST00000075084.4 ENSMUSP00000074594.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 6.10e-06 27.8 15 59
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ +++ p++++CgH f++ C+  +  +++s+++   CP Cr
   Q: 15   CSVCLDFLQE-PISVDCGHSFCLRCISEFCEKSDSAQGVYACPQCR 59
           ********99.***************9999999************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
 E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
Protein Sequence
(Fasta)
MATAPGERLQ EEARCSVCLD FLQEPISVDC GHSFCLRCIS EFCEKSDSAQ GVYACPQCRG 60
PFRPASFRPN RQLASLVDSV RQLGLGTGHA GSRQCARHGE DLSHFCEEDQ TMLCWVCDTS 120
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Protein Fasta Sequence


>IUUC-Mmu-063326|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GCCATGGCCA CGGCACCCGG GGAGCGACTG CAGGAGGAGG CGCGGTGCTC CGTGTGCCTG 60
GACTTCCTGC AGGAGCCCAT CAGCGTGGAC TGCGGCCACA GTTTCTGTCT GCGGTGCATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063326|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005622--C:intracellular
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
KEGG mmu:216781
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001785 Ailuropoda melanoleuca 72.48 0.00e+00 649.00
IUUC-Aca-004891 Anolis carolinensis 44.17 5.00e-93 334.00
IUUC-Bta-012726 Bos taurus 81.14 0.00e+00 714.00
IUUC-Cja-018951 Callithrix jacchus 77.37 0.00e+00 671.00
IUUC-Cfa-021114 Canis familiaris 78.05 0.00e+00 718.00
IUUC-Cpo-021630 Cavia porcellus 64.52 1.00e-150 526.00
IUUC-Cho-024849 Choloepus hoffmanni 77.62 2.00e-106 378.00
IUUC-Dno-029530 Dasypus novemcinctus 79.11 0.00e+00 686.00
IUUC-Eeu-035044 Erinaceus europaeus 78.28 2.00e-104 372.00
IUUC-Fca-035988 Felis catus 79.57 0.00e+00 724.00
IUUC-Hsa-046978 Homo sapiens 79.17 0.00e+00 688.00
IUUC-Laf-054172 Loxodonta africana 80.58 0.00e+00 740.00
IUUC-Mdo-062418 Monodelphis domestica 62.28 6.00e-167 580.00
IUUC-Mpu-066338 Mustela putorius furo 76.09 0.00e+00 681.00
IUUC-Mlu-067864 Myotis lucifugus 71.10 9.00e-172 596.00
IUUC-Nle-069883 Nomascus leucogenys 79.79 0.00e+00 743.00
IUUC-Opr-070347 Ochotona princeps 68.94 2.00e-154 538.00
IUUC-Oan-073120 Ornithorhynchus anatinus 54.60 1.00e-118 419.00
IUUC-Ocu-074489 Oryctolagus cuniculus 71.82 6.00e-108 384.00
IUUC-Oga-087926 Otolemur garnettii 75.98 0.00e+00 721.00
IUUC-Oar-090340 Ovis aries 80.04 0.00e+00 717.00
IUUC-Ptr-091292 Pan troglodytes 77.53 0.00e+00 669.00
IUUC-Pan-092710 Papio anubis 80.00 0.00e+00 670.00
IUUC-Pab-098011 Pongo abelii 80.00 0.00e+00 698.00
IUUC-Pca-100277 Procavia capensis 77.22 1.00e-113 403.00
IUUC-Pva-103101 Pteropus vampyrus 77.85 0.00e+00 710.00
IUUC-Rno-105618 Rattus norvegicus 94.23 0.00e+00 872.00
IUUC-Sha-106630 Sarcophilus harrisii 60.56 5.00e-156 544.00
IUUC-Ssc-116382 Sus scrofa 78.74 0.00e+00 709.00
IUUC-Tsy-119220 Tarsius syrichta 70.48 2.00e-163 568.00
IUUC-Ttr-129036 Tursiops truncatus 79.00 0.00e+00 682.00
Created Date 25-Jun-2017

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