iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-14	54.3	48	103

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvkelegkrGlfPenFvek 61
            +l+dye++ +deL l+kGd v+v+      + degW+ g  +  g+ G+fP+n+v +
   Q: 48   TALFDYEPNGQDELALRKGDRVEVLsrdAAISGDEGWWAG--QVGGQVGIFPSNYVSR 103
           69***********************66555689*******..7************975 PP

Organism

Rattus norvegicus

Functional Description
(View)

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity).

Protein Sequence
(Fasta)

MEPLKNLFLK SPLGSWNGSG SGGGGGSGGV RPEGSPKATA AYANPVWTAL FDYEPNGQDE 60
LALRKGDRVE VLSRDAAISG DEGWWAGQVG GQVGIFPSNY VSRGGGPPPC EVASFQELRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGAGAAGA GGTAGCTTCG GCTCTATTGG AGACTTTCTC TTACCTCTTG TATCTCAAGA 60
CAACAACCAG AGTCCAGGCG CCGACCCTGG CAGGCCCCAC CTTACAGTAG GCGGGCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00326--SH3

Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0004709--F:MAP kinase kinase kinase activity
GO:0031434--F:mitogen-activated protein kinase kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0048365--F:Rac GTPase binding
GO:0007256--P:activation of JNKK activity
GO:0007257--P:activation of JUN kinase activity
GO:0008219--P:cell death
GO:0008283--P:cell proliferation
GO:0007254--P:JNK cascade
GO:0007017--P:microtubule-based process
GO:0043065--P:positive regulation of apoptotic process
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation

KEGG

rno:309168

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002080	Ailuropoda melanoleuca	93.46	0.00e+00	1016.00
IUUC-Ame-011785	Astyanax mexicanus	69.82	0.00e+00	707.00
IUUC-Bta-012372	Bos taurus	90.29	0.00e+00	1110.00
IUUC-Bol-015857	Brassica oleracea	33.50	6.00e-27	115.00
IUUC-Cja-019543	Callithrix jacchus	89.65	0.00e+00	1121.00
IUUC-Cfa-020080	Canis familiaris	97.72	0.00e+00	1005.00
IUUC-Cpo-022478	Cavia porcellus	92.71	0.00e+00	1175.00
IUUC-Csa-023280	Chlorocebus sabaeus	98.31	0.00e+00	995.00
IUUC-Dno-030074	Dasypus novemcinctus	89.02	0.00e+00	1245.00
IUUC-Dor-030866	Dipodomys ordii	93.88	0.00e+00	1191.00
IUUC-Eca-033782	Equus caballus	97.27	1.00e-171	596.00
IUUC-Fca-035440	Felis catus	96.08	0.00e+00	1047.00
IUUC-Gac-042299	Gasterosteus aculeatus	67.30	0.00e+00	703.00
IUUC-Ggo-044795	Gorilla gorilla	92.95	0.00e+00	1162.00
IUUC-Hsa-046270	Homo sapiens	92.60	0.00e+00	1188.00
IUUC-Itr-048561	Ictidomys tridecemlineatus	94.35	0.00e+00	1172.00
IUUC-Lch-049724	Latimeria chalumnae	55.21	0.00e+00	716.00
IUUC-Meu-056762	Macropus eugenii	90.60	0.00e+00	754.00
IUUC-Mdo-062929	Monodelphis domestica	82.30	0.00e+00	1150.00
IUUC-Mmu-063196	Mus musculus	98.12	0.00e+00	1238.00
IUUC-Mpu-066569	Mustela putorius furo	90.92	0.00e+00	1205.00
IUUC-Mlu-067815	Myotis lucifugus	91.84	0.00e+00	1134.00
IUUC-Ont-071274	Oreochromis niloticus	68.57	0.00e+00	716.00
IUUC-Ocu-074842	Oryctolagus cuniculus	91.40	0.00e+00	1182.00
IUUC-Ome-081788	Oryza meridionalis	30.15	6.00e-31	129.00
IUUC-Ola-086581	Oryzias latipes	62.65	0.00e+00	721.00
IUUC-Oga-088038	Otolemur garnettii	92.60	0.00e+00	1181.00
IUUC-Oar-089467	Ovis aries	89.43	0.00e+00	1108.00
IUUC-Ptr-090955	Pan troglodytes	92.71	0.00e+00	1191.00
IUUC-Pan-091695	Papio anubis	93.54	0.00e+00	1179.00
IUUC-Psi-093760	Pelodiscus sinensis	75.00	0.00e+00	889.00
IUUC-Pfo-096248	Poecilia formosa	59.08	0.00e+00	703.00
IUUC-Pab-097966	Pongo abelii	92.95	0.00e+00	1193.00
IUUC-Pca-100802	Procavia capensis	98.90	4.00e-101	362.00
IUUC-Pva-102546	Pteropus vampyrus	90.87	0.00e+00	1137.00
IUUC-Sha-107470	Sarcophilus harrisii	76.62	0.00e+00	1071.00
IUUC-Tni-120577	Tetraodon nigroviridis	62.62	0.00e+00	703.00
IUUC-Ttr-129146	Tursiops truncatus	94.87	0.00e+00	1057.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence