iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.30e-07	31.6	39	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  ++  CgH+f+  Cl++w        +++ CP+C+
   Q: 39   CNICLDTAKD-AVISLCGHLFCWPCLHQW---LETRPNRQVCPVCK 80
           99********.77788*************...666999999****7 PP

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.

Protein Sequence
(Fasta)

MASKGPSASA STENSSAGGP SGSSNGTGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW 60
PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR 120

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Nucleotide Sequence
(Fasta)

TTCGGAGGTT CAATCTTCCT GACTGACGCG TCTCTAAGAC TGGCTTGTCC ACTGTGGGAC 60
AGGGGAACGG ACTGGTGGCG TCGCTGGCGC TCGCTCTACG GGGACAGGTA CGTGACGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

rno:360967

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001042	Aegilops tauschii	51.61	2.00e-24	105.00
IUUC-Aml-001875	Ailuropoda melanoleuca	100.00	2.00e-62	231.00
IUUC-Atr-002721	Amborella trichopoda	54.35	2.00e-25	108.00
IUUC-Apl-003744	Anas platyrhynchos	100.00	4.00e-40	155.00
IUUC-Aly-006065	Arabidopsis lyrata	56.98	7.00e-26	110.00
IUUC-Ath-007401	Arabidopsis thaliana	54.55	1.00e-24	106.00
IUUC-Ame-011667	Astyanax mexicanus	96.79	7.00e-53	199.00
IUUC-Bgr-012018	Blumeria graminis	40.98	2.00e-09	56.60
IUUC-Bta-012734	Bos taurus	100.00	3.00e-62	230.00
IUUC-Bci-013671	Botrytis cinerea	48.98	1.00e-09	57.40
IUUC-Bol-016132	Brassica oleracea	56.18	2.00e-26	112.00
IUUC-Bra-017631	Brassica rapa	33.49	2.00e-26	112.00
IUUC-Cel-018228	Caenorhabditis elegans	70.59	2.00e-34	139.00
IUUC-Cja-019136	Callithrix jacchus	99.38	5.00e-62	229.00
IUUC-Cfa-020308	Canis familiaris	100.00	2.00e-62	231.00
IUUC-Cpo-021347	Cavia porcellus	98.75	1.00e-61	228.00
IUUC-Cre-022829	Chlamydomonas reinhardtii	56.32	2.00e-26	109.00
IUUC-Csa-023755	Chlorocebus sabaeus	98.44	2.00e-66	244.00
IUUC-Cgl-026743	Colletotrichum gloeosporioides	38.78	5.00e-08	52.40
IUUC-Dre-028094	Danio rerio	96.86	2.00e-59	221.00
IUUC-Dno-029402	Dasypus novemcinctus	100.00	2.00e-62	231.00
IUUC-Dor-030373	Dipodomys ordii	100.00	2.00e-62	231.00
IUUC-Dme-031966	Drosophila melanogaster	60.98	4.00e-56	211.00
IUUC-Ete-032786	Echinops telfairi	97.40	9.00e-65	239.00
IUUC-Eca-034261	Equus caballus	100.00	2.00e-62	231.00
IUUC-Eeu-034614	Erinaceus europaeus	90.00	1.00e-49	188.00
IUUC-Fca-036049	Felis catus	100.00	2.00e-62	231.00
IUUC-Fal-037085	Ficedula albicollis	98.76	6.00e-62	229.00
IUUC-Gmo-039369	Gadus morhua	94.51	1.00e-55	208.00
IUUC-Gga-040514	Gallus gallus	99.38	8.00e-62	229.00
IUUC-Gac-041719	Gasterosteus aculeatus	95.73	9.00e-57	212.00
IUUC-Gma-043248	Glycine max	59.30	5.00e-27	114.00
IUUC-Ggo-044504	Gorilla gorilla	100.00	2.00e-62	231.00
IUUC-Hsa-045707	Homo sapiens	100.00	2.00e-62	231.00
IUUC-Hvu-047487	Hordeum vulgare	52.75	5.00e-24	104.00
IUUC-Itr-048343	Ictidomys tridecemlineatus	97.40	8.00e-64	236.00
IUUC-Lch-050658	Latimeria chalumnae	93.12	2.00e-59	221.00
IUUC-Loc-052118	Lepisosteus oculatus	96.95	2.00e-57	214.00
IUUC-Laf-054438	Loxodonta africana	98.44	6.00e-65	239.00
IUUC-Mcc-054641	Macaca mulatta	95.31	3.00e-59	220.00
IUUC-Meu-056828	Macropus eugenii	80.58	3.00e-34	135.00
IUUC-Mor-057077	Magnaporthe oryzae	37.29	2.00e-08	53.90
IUUC-Mpo-057431	Magnaporthe poae	35.29	6.00e-09	55.80
IUUC-Mtr-058107	Medicago truncatula	59.30	2.00e-26	112.00
IUUC-Mga-059554	Meleagris gallopavo	99.38	8.00e-62	229.00
IUUC-Mvi-060316	Microbotryum violaceum	50.88	6.00e-12	64.30
IUUC-Mmr-061662	Microcebus murinus	93.87	1.00e-53	202.00
IUUC-Mdo-062774	Monodelphis domestica	100.00	2.00e-62	231.00
IUUC-Mmu-063372	Mus musculus	99.48	7.00e-67	246.00
IUUC-Mpu-066033	Mustela putorius furo	100.00	7.00e-63	236.00
IUUC-Mlu-067254	Myotis lucifugus	100.00	2.00e-62	231.00
IUUC-Ncr-068628	Neurospora crassa	43.14	5.00e-10	58.90
IUUC-Nle-069850	Nomascus leucogenys	100.00	2.00e-62	231.00
IUUC-Opr-070197	Ochotona princeps	88.12	4.00e-58	217.00
IUUC-Ont-071950	Oreochromis niloticus	97.45	1.00e-58	218.00
IUUC-Oan-073480	Ornithorhynchus anatinus	100.00	2.00e-62	231.00
IUUC-Ocu-073878	Oryctolagus cuniculus	91.88	1.00e-62	231.00
IUUC-Oba-075248	Oryza barthii	55.84	1.00e-23	102.00
IUUC-Ola-086800	Oryzias latipes	97.50	1.00e-55	209.00
IUUC-Oga-088197	Otolemur garnettii	100.00	4.00e-65	240.00
IUUC-Ptr-091106	Pan troglodytes	100.00	2.00e-62	231.00
IUUC-Pan-092671	Papio anubis	98.44	2.00e-66	244.00
IUUC-Psi-093323	Pelodiscus sinensis	100.00	3.00e-62	230.00
IUUC-Pno-094942	Phaeosphaeria nodorum	42.68	3.00e-10	59.30
IUUC-Ppa-095474	Physcomitrella patens	55.91	2.00e-26	112.00
IUUC-Pfo-096943	Poecilia formosa	96.25	7.00e-55	206.00
IUUC-Pab-097845	Pongo abelii	100.00	2.00e-62	231.00
IUUC-Pop-098988	Populus trichocarpa	53.19	3.00e-26	111.00
IUUC-Ppe-102011	Prunus persica	58.14	2.00e-26	112.00
IUUC-Pva-102298	Pteropus vampyrus	100.00	2.00e-62	231.00
IUUC-Pyt-104640	Pyrenophora triticirepentis	37.50	6.00e-10	58.20
IUUC-Sha-107361	Sarcophilus harrisii	95.31	3.00e-65	241.00
IUUC-Sit-110376	Setaria italica	55.81	9.00e-25	106.00
IUUC-Stu-112801	Solanum tuberosum	54.65	3.00e-24	105.00
IUUC-Sar-113669	Sorex araneus	100.00	8.00e-26	108.00
IUUC-Ssc-116228	Sus scrofa	100.00	2.00e-62	231.00
IUUC-Tgu-116886	Taeniopygia guttata	98.76	6.00e-62	229.00
IUUC-Tni-120909	Tetraodon nigroviridis	93.90	1.00e-56	212.00
IUUC-Tae-124870	Triticum aestivum	51.61	4.00e-24	104.00
IUUC-Tur-126676	Triticum urartu	52.94	3.00e-23	101.00
IUUC-Tbe-127360	Tupaia belangeri	100.00	2.00e-43	167.00
IUUC-Ttr-129044	Tursiops truncatus	100.00	2.00e-62	231.00
IUUC-Vda-129983	Verticillium dahliae	43.75	1.00e-08	53.10
IUUC-Vpa-130365	Vicugna pacos	99.38	1.00e-61	228.00
IUUC-Vvi-131449	Vitis vinifera	56.32	2.00e-26	112.00
IUUC-Xtr-131916	Xenopus tropicalis	94.57	2.00e-42	164.00
IUUC-Xma-133333	Xiphophorus maculatus	93.90	3.00e-55	207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence