iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035434

Ensembl Protein ID

ENSFCAP00000009858.3

UniProt Accession

M3WDL2; M3WDL2_FELCA

Genbank Protein ID

ENSFCAP00000009858

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AANG02097975

Gene Name

WHSC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000010620.3	ENSFCAT00000010622.3	ENSFCAP00000009858.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	8.40e-10	38.7	649	689

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 649  WCFVCSKGGS----LLCCESCPAAFHPDCLSIE----MPDGS-WFCNECR 689
           8*********....*******************....9***8.******8 PP

Organism

Felis catus

Protein Sequence
(Fasta)

SDSRVAAKKE SCPNTGRDKD HLLKYSVGDL VWSKVSGYPW WPCMVSADPL LHNYTKLKEK 60
LGQKKSARQY HVQFFGDAPE RAWIFEKSLV AFEGEGQFEK LCQESAKQAP TKAEKIKLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGATAGCA GGGGAAGCAC TCTCCTTGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG 60
TGTGTGTGTG TGTGTGTGTG TGTGTGAGAG AGAGAGAGAG AGAGAGAGAG AGAGAGAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002181	Ailuropoda melanoleuca	90.43	0.00e+00	2054.00
IUUC-Apl-003677	Anas platyrhynchos	77.62	0.00e+00	1766.00
IUUC-Aca-004278	Anolis carolinensis	72.09	0.00e+00	1332.00
IUUC-Ame-011932	Astyanax mexicanus	67.88	0.00e+00	981.00
IUUC-Bta-012522	Bos taurus	85.10	0.00e+00	1904.00
IUUC-Cja-018908	Callithrix jacchus	86.81	0.00e+00	1924.00
IUUC-Cfa-020894	Canis familiaris	89.08	0.00e+00	2071.00
IUUC-Cpo-021982	Cavia porcellus	84.23	0.00e+00	1945.00
IUUC-Csa-023807	Chlorocebus sabaeus	87.52	0.00e+00	1952.00
IUUC-Cho-024405	Choloepus hoffmanni	67.54	0.00e+00	644.00
IUUC-Cme-027319	Cyanidioschyzon merolae	30.00	4.80e-01	28.10
IUUC-Dre-027492	Danio rerio	68.66	0.00e+00	1022.00
IUUC-Dno-030020	Dasypus novemcinctus	83.28	0.00e+00	1655.00
IUUC-Dor-031103	Dipodomys ordii	79.10	0.00e+00	1722.00
IUUC-Ete-032488	Echinops telfairi	77.69	0.00e+00	1698.00
IUUC-Eca-034066	Equus caballus	88.32	0.00e+00	2043.00
IUUC-Eeu-035199	Erinaceus europaeus	65.61	0.00e+00	679.00
IUUC-Fal-037113	Ficedula albicollis	74.75	0.00e+00	1758.00
IUUC-Gmo-039686	Gadus morhua	67.30	0.00e+00	964.00
IUUC-Gga-040273	Gallus gallus	74.62	0.00e+00	1744.00
IUUC-Gac-042123	Gasterosteus aculeatus	51.69	0.00e+00	1128.00
IUUC-Ggo-044643	Gorilla gorilla	87.14	0.00e+00	1972.00
IUUC-Hsa-046380	Homo sapiens	87.05	0.00e+00	1935.00
IUUC-Itr-048658	Ictidomys tridecemlineatus	86.23	0.00e+00	1347.00
IUUC-Lch-050217	Latimeria chalumnae	66.75	0.00e+00	1497.00
IUUC-Loc-052766	Lepisosteus oculatus	55.37	0.00e+00	1207.00
IUUC-Laf-053780	Loxodonta africana	84.40	0.00e+00	1969.00
IUUC-Mcc-054928	Macaca mulatta	87.43	0.00e+00	1980.00
IUUC-Meu-056184	Macropus eugenii	72.09	0.00e+00	780.00
IUUC-Mga-059576	Meleagris gallopavo	75.37	0.00e+00	1725.00
IUUC-Mmr-061045	Microcebus murinus	86.36	0.00e+00	2016.00
IUUC-Mdo-062576	Monodelphis domestica	78.63	0.00e+00	1828.00
IUUC-Mmu-063640	Mus musculus	85.75	0.00e+00	1925.00
IUUC-Mac-065303	Musa acuminata	29.22	3.00e-11	63.50
IUUC-Mpu-066512	Mustela putorius furo	90.09	0.00e+00	2045.00
IUUC-Mlu-067280	Myotis lucifugus	76.10	0.00e+00	1019.00
IUUC-Nle-069896	Nomascus leucogenys	87.17	0.00e+00	1856.00
IUUC-Ont-072197	Oreochromis niloticus	69.10	0.00e+00	972.00
IUUC-Oan-072724	Ornithorhynchus anatinus	75.35	0.00e+00	1303.00
IUUC-Ocu-074758	Oryctolagus cuniculus	83.53	0.00e+00	1876.00
IUUC-Olo-080702	Oryza longistaminata	41.94	3.00e-45	177.00
IUUC-Opu-083371	Oryza punctata	42.31	5.00e-47	182.00
IUUC-Oga-088702	Otolemur garnettii	85.52	0.00e+00	1674.00
IUUC-Oar-089736	Ovis aries	77.62	0.00e+00	1588.00
IUUC-Ptr-091055	Pan troglodytes	86.96	0.00e+00	1932.00
IUUC-Pan-092752	Papio anubis	88.93	0.00e+00	1328.00
IUUC-Psi-093620	Pelodiscus sinensis	77.89	0.00e+00	1776.00
IUUC-Pfo-097464	Poecilia formosa	53.02	0.00e+00	1100.00
IUUC-Pab-098051	Pongo abelii	86.96	0.00e+00	1964.00
IUUC-Pop-099927	Populus trichocarpa	28.96	9.00e-12	65.90
IUUC-Pca-100273	Procavia capensis	84.60	0.00e+00	1944.00
IUUC-Ppe-101635	Prunus persica	28.02	4.00e-11	63.50
IUUC-Pva-102473	Pteropus vampyrus	79.47	0.00e+00	1336.00
IUUC-Rno-105056	Rattus norvegicus	85.45	0.00e+00	1944.00
IUUC-Sha-107494	Sarcophilus harrisii	79.64	0.00e+00	1828.00
IUUC-Sar-113310	Sorex araneus	86.41	0.00e+00	1778.00
IUUC-Ssc-116344	Sus scrofa	84.05	0.00e+00	1896.00
IUUC-Tgu-116786	Taeniopygia guttata	76.59	0.00e+00	1753.00
IUUC-Tru-117638	Takifugu rubripes	52.92	0.00e+00	1144.00
IUUC-Tsy-118937	Tarsius syrichta	87.76	0.00e+00	1430.00
IUUC-Tni-120452	Tetraodon nigroviridis	67.28	0.00e+00	982.00
IUUC-Tbe-127291	Tupaia belangeri	81.37	0.00e+00	1410.00
IUUC-Ttr-129017	Tursiops truncatus	80.60	0.00e+00	1445.00
IUUC-Xtr-132673	Xenopus tropicalis	67.76	0.00e+00	1512.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence