iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053910

Ensembl Protein ID

ENSLAFP00000006222.3

UniProt Accession

G3SZX6; G3SZX6_LOXAF

Protein Name

Uncharacterized protein

Gene Name

SLX4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000007395.3	ENSLAFT00000007395.3	ENSLAFP00000006222.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.70e-06	27.2	527	596
UBD/ZnF/UBZ	2.00e-08	34.7	119	144

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmelees.........ksklmveikdvqpevfrallkFlYtgk 64
           +Dv+++v+ ge+  ahk vL a+++ +    ++   e+         + + +v ++dv+ e+ r++l++lYt  
   Q: 527  SDVQFQVDsGEVLYAHKFVLYARCPLLIQHVNS---EGffavedgdlR-TQRVLLSDVSTEAARVFLHYLYTAD 596
           69***********************98666533...344444556767.99*********************75 PP

UBD/ZnF/UBZ

   S: 2    lvCPvCqkm...vdqtdfeeHlDeCl 24
           ++C++Cqk    +++t++e+H+++Cl
   Q: 119  FFCQICQKNlssMNVTRREQHMNRCL 144
           58***********************8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

SLLEGAPSSD TQPSSSGLTV VAPSPSKLRT AELVLQRMQR FKRADPARLK HAPGACSLKA 60
MIAENAPKDP QEEPMVGNGC EPGSPATEND GVMALALQQE LGQERVPTLE ESLEEEGWFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTTGCTAG AGGGTGCTCC TAGCAGTGAC ACCCAGCCCT CTTCTTCCGG GCTGACCGTG 60
GTGGCTCCCA GTCCCTCCAA GCTGCGGACA GCAGAGTTGG TCCTCCAGCG AATGCAACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR018574--Structure-sp_endonuc_su_Slx4

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF09494--Slx4

SMART

SM00225--BTB

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0070522--C:ERCC4-ERCC1 complex
GO:0048476--C:Holliday junction resolvase complex
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0033557--C:Slx1-Slx4 complex
GO:0048257--F:3'-flap endonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0008821--F:crossover junction endodeoxyribonuclease activity
GO:0008047--F:enzyme activator activity
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0006260--P:DNA replication
GO:0000724--P:double-strand break repair via homologous recombination
GO:1904357--P:negative regulation of telomere maintenance via telomere lengthening
GO:0006289--P:nucleotide-excision repair
GO:1904431--P:positive regulation of t-circle formation
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
GO:0090656--P:t-circle formation
GO:0061820--P:telomeric D-loop disassembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001225	Ailuropoda melanoleuca	59.45	0.00e+00	1368.00
IUUC-Apl-003261	Anas platyrhynchos	36.14	0.00e+00	712.00
IUUC-Aca-004455	Anolis carolinensis	60.87	2.00e-18	83.60
IUUC-Ame-010993	Astyanax mexicanus	32.43	2.00e-10	58.90
IUUC-Bta-013472	Bos taurus	54.01	0.00e+00	857.00
IUUC-Cel-018663	Caenorhabditis elegans	38.64	4.00e-03	37.00
IUUC-Cja-019406	Callithrix jacchus	56.14	0.00e+00	1247.00
IUUC-Cfa-020129	Canis familiaris	55.50	0.00e+00	1177.00
IUUC-Cpo-021944	Cavia porcellus	52.54	0.00e+00	1163.00
IUUC-Csa-023941	Chlorocebus sabaeus	50.48	6.00e-162	564.00
IUUC-Cho-024847	Choloepus hoffmanni	70.89	3.00e-128	453.00
IUUC-Cin-025405	Ciona intestinalis	32.35	8.00e-15	74.30
IUUC-Csv-025916	Ciona savignyi	32.20	6.00e-07	47.80
IUUC-Dre-027764	Danio rerio	34.89	3.00e-71	264.00
IUUC-Dno-030083	Dasypus novemcinctus	56.39	0.00e+00	1257.00
IUUC-Dor-031129	Dipodomys ordii	46.53	0.00e+00	847.00
IUUC-Dse-031510	Dothistroma septosporum	33.33	1.00e+00	29.60
IUUC-Ete-032536	Echinops telfairi	52.54	3.00e-145	509.00
IUUC-Eca-033407	Equus caballus	60.64	0.00e+00	1259.00
IUUC-Eeu-034473	Erinaceus europaeus	43.45	1.00e-42	169.00
IUUC-Fca-035730	Felis catus	57.12	0.00e+00	1406.00
IUUC-Fal-036850	Ficedula albicollis	48.22	8.00e-144	505.00
IUUC-Gmo-038677	Gadus morhua	43.66	2.00e-30	127.00
IUUC-Gga-041088	Gallus gallus	45.27	3.00e-138	487.00
IUUC-Gac-041824	Gasterosteus aculeatus	50.00	3.00e-14	71.20
IUUC-Ggo-045642	Gorilla gorilla	57.04	0.00e+00	1210.00
IUUC-Hsa-047035	Homo sapiens	57.19	0.00e+00	1318.00
IUUC-Itr-049010	Ictidomys tridecemlineatus	55.77	0.00e+00	1282.00
IUUC-Kpa-049328	Komagataella pastoris	33.33	1.00e-03	38.10
IUUC-Lch-050364	Latimeria chalumnae	40.70	6.00e-79	289.00
IUUC-Loc-052423	Lepisosteus oculatus	41.49	2.00e-44	174.00
IUUC-Mcc-055883	Macaca mulatta	57.50	0.00e+00	1327.00
IUUC-Meu-056224	Macropus eugenii	50.13	1.00e-90	328.00
IUUC-Mga-059880	Meleagris gallopavo	36.99	0.00e+00	676.00
IUUC-Mvi-060510	Microbotryum violaceum	34.92	1.00e-05	45.80
IUUC-Mmr-061715	Microcebus murinus	57.53	0.00e+00	1410.00
IUUC-Mdo-062426	Monodelphis domestica	43.40	0.00e+00	932.00
IUUC-Mmu-063947	Mus musculus	53.15	0.00e+00	1285.00
IUUC-Mpu-066184	Mustela putorius furo	55.52	0.00e+00	1281.00
IUUC-Mlu-067533	Myotis lucifugus	58.19	0.00e+00	1356.00
IUUC-Nle-069204	Nomascus leucogenys	56.35	0.00e+00	1304.00
IUUC-Opr-070377	Ochotona princeps	60.88	0.00e+00	738.00
IUUC-Ont-072551	Oreochromis niloticus	32.30	6.00e-66	246.00
IUUC-Oan-073350	Ornithorhynchus anatinus	56.30	1.00e-96	346.00
IUUC-Ocu-074915	Oryctolagus cuniculus	58.70	0.00e+00	772.00
IUUC-Ola-087360	Oryzias latipes	43.24	1.00e-34	139.00
IUUC-Oga-089106	Otolemur garnettii	56.68	0.00e+00	1154.00
IUUC-Oar-089289	Ovis aries	56.34	0.00e+00	777.00
IUUC-Ptr-091469	Pan troglodytes	57.37	0.00e+00	1314.00
IUUC-Pan-091841	Papio anubis	56.63	0.00e+00	1095.00
IUUC-Psi-093842	Pelodiscus sinensis	48.15	8.00e-138	485.00
IUUC-Pma-094732	Petromyzon marinus	54.93	5.00e-09	53.90
IUUC-Pfo-097299	Poecilia formosa	39.56	2.00e-34	141.00
IUUC-Pab-098271	Pongo abelii	56.28	0.00e+00	1313.00
IUUC-Pca-100721	Procavia capensis	65.84	0.00e+00	1056.00
IUUC-Pva-102276	Pteropus vampyrus	59.62	0.00e+00	1503.00
IUUC-Rno-105619	Rattus norvegicus	52.50	0.00e+00	1196.00
IUUC-Sha-106722	Sarcophilus harrisii	45.27	0.00e+00	1059.00
IUUC-Sar-113673	Sorex araneus	57.07	4.00e-72	267.00
IUUC-Sre-115039	Sporisorium reilianum	33.33	4.00e-05	42.00
IUUC-Ssc-115383	Sus scrofa	56.77	0.00e+00	733.00
IUUC-Tgu-117243	Taeniopygia guttata	49.14	3.00e-97	348.00
IUUC-Tru-118092	Takifugu rubripes	41.70	1.00e-31	130.00
IUUC-Tsy-119362	Tarsius syrichta	49.39	9.00e-129	455.00
IUUC-Tni-120380	Tetraodon nigroviridis	76.79	1.00e-20	93.20
IUUC-Tbe-127404	Tupaia belangeri	45.81	4.00e-175	609.00
IUUC-Ttr-128317	Tursiops truncatus	59.05	0.00e+00	1248.00
IUUC-Uma-129640	Ustilago maydis	34.72	1.00e-05	43.90
IUUC-Xtr-132533	Xenopus tropicalis	39.71	1.00e-89	325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence