iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-117280

Ensembl Protein ID

ENSTGUP00000004463.1

UniProt Accession

H0Z1M3; H0Z1M3_TAEGU

Genbank Protein ID

ENSTGUP00000004463

Protein Name

Presenilin

Genbank Nucleotide ID

ABQF01123118

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000004332.1	ENSTGUT00000004511.1	ENSTGUP00000004463.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	5.60e-06	26.2	284	319

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavn 37
           +eta+e++++iFP+l+ys+ + + + +++ ++aa +
   Q: 284  VETAQERNEPIFPALIYSSAMMWTVGMAKPDTAARG 319
           89**********************999987777765 PP

Organism

Taeniopygia guttata

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFMNNSDS EEEPCNERTS LMSAESPPVP SYQDGLQASE AGEAQAHRKR RAGSSRGPNN 60
IAGGEMSGSG VPVRERALEN EEEELTLKYG AKHVIMLFVP VTLCMIVVVA TIKSVRFYTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATCACGT TCATGAACAA TTCGGACAGT GAGGAGGAGC CCTGCAATGA GAGAACATCC 60
CTGATGTCTG CAGAGAGCCC TCCAGTACCC TCCTACCAGG ATGGCCTGCA AGCCTCGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

KEGG

tgu:100232599

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	71.74	1.00e-134	472.00
IUUC-Apl-003959	Anas platyrhynchos	90.54	0.00e+00	709.00
IUUC-Aca-005160	Anolis carolinensis	83.22	2.00e-179	620.00
IUUC-Aly-005455	Arabidopsis lyrata	60.49	2.00e-17	83.20
IUUC-Ath-006730	Arabidopsis thaliana	60.49	2.00e-17	83.60
IUUC-Ame-010686	Astyanax mexicanus	79.41	3.00e-140	491.00
IUUC-Bta-013097	Bos taurus	76.96	4.00e-162	563.00
IUUC-Bol-015841	Brassica oleracea	35.50	2.00e-30	126.00
IUUC-Bra-017580	Brassica rapa	61.73	9.00e-18	84.00
IUUC-Cel-018553	Caenorhabditis elegans	52.59	3.00e-90	325.00
IUUC-Cja-018824	Callithrix jacchus	75.87	1.00e-158	552.00
IUUC-Cfa-020253	Canis familiaris	77.17	2.00e-162	565.00
IUUC-Cpo-021401	Cavia porcellus	75.59	2.00e-160	558.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.10	1.00e-27	117.00
IUUC-Csa-023369	Chlorocebus sabaeus	76.96	1.00e-162	565.00
IUUC-Cin-025780	Ciona intestinalis	62.94	7.00e-121	426.00
IUUC-Csv-025967	Ciona savignyi	60.19	8.00e-118	416.00
IUUC-Dre-028526	Danio rerio	70.68	2.00e-147	514.00
IUUC-Dor-031127	Dipodomys ordii	74.40	2.00e-159	554.00
IUUC-Dme-031929	Drosophila melanogaster	53.62	1.00e-108	386.00
IUUC-Ete-033081	Echinops telfairi	69.79	2.00e-74	272.00
IUUC-Eca-034387	Equus caballus	76.30	7.00e-156	543.00
IUUC-Eeu-034846	Erinaceus europaeus	62.21	5.00e-107	380.00
IUUC-Fca-035396	Felis catus	76.69	1.00e-166	578.00
IUUC-Fal-037457	Ficedula albicollis	98.47	0.00e+00	769.00
IUUC-Gmo-038550	Gadus morhua	71.10	1.00e-125	442.00
IUUC-Gga-040706	Gallus gallus	89.52	0.00e+00	681.00
IUUC-Gac-042511	Gasterosteus aculeatus	67.45	7.00e-134	469.00
IUUC-Gma-043822	Glycine max	37.69	2.00e-24	105.00
IUUC-Ggo-045338	Gorilla gorilla	76.96	1.00e-162	565.00
IUUC-Hsa-046455	Homo sapiens	76.96	1.00e-162	565.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	77.17	2.00e-162	564.00
IUUC-Lch-049638	Latimeria chalumnae	69.38	8.00e-151	526.00
IUUC-Loc-052427	Lepisosteus oculatus	74.68	4.00e-163	566.00
IUUC-Laf-053758	Loxodonta africana	75.49	8.00e-171	592.00
IUUC-Mcc-054755	Macaca mulatta	76.96	3.00e-162	564.00
IUUC-Mtr-058392	Medicago truncatula	34.92	4.00e-29	122.00
IUUC-Mmr-060890	Microcebus murinus	76.30	2.00e-161	561.00
IUUC-Mdo-062197	Monodelphis domestica	77.73	1.00e-173	602.00
IUUC-Mmu-063823	Mus musculus	75.70	4.00e-162	563.00
IUUC-Mpu-066181	Mustela putorius furo	76.96	5.00e-162	563.00
IUUC-Nle-069596	Nomascus leucogenys	73.96	2.00e-147	514.00
IUUC-Opr-070344	Ochotona princeps	76.30	2.00e-164	571.00
IUUC-Ont-071867	Oreochromis niloticus	69.74	1.00e-136	479.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.79	2.00e-156	544.00
IUUC-Ocu-074652	Oryctolagus cuniculus	76.09	4.00e-160	557.00
IUUC-Ola-086707	Oryzias latipes	71.06	1.00e-104	372.00
IUUC-Oga-088560	Otolemur garnettii	75.81	9.00e-158	549.00
IUUC-Oar-089200	Ovis aries	76.30	3.00e-159	554.00
IUUC-Ptr-090569	Pan troglodytes	76.74	8.00e-162	562.00
IUUC-Pan-091742	Papio anubis	76.96	2.00e-162	565.00
IUUC-Psi-093297	Pelodiscus sinensis	85.24	2.00e-160	557.00
IUUC-Pma-094612	Petromyzon marinus	75.52	2.00e-127	449.00
IUUC-Ppa-095431	Physcomitrella patens	32.93	9.00e-25	107.00
IUUC-Pfo-097396	Poecilia formosa	71.36	6.00e-134	470.00
IUUC-Pab-098531	Pongo abelii	76.96	1.00e-162	565.00
IUUC-Pca-101120	Procavia capensis	74.57	1.00e-153	535.00
IUUC-Pva-102934	Pteropus vampyrus	70.87	7.00e-155	540.00
IUUC-Rno-106052	Rattus norvegicus	75.59	7.00e-166	576.00
IUUC-Sha-106876	Sarcophilus harrisii	77.75	1.00e-173	602.00
IUUC-Stu-112433	Solanum tuberosum	32.12	1.00e-27	117.00
IUUC-Ssc-115380	Sus scrofa	77.39	1.00e-163	569.00
IUUC-Tru-117732	Takifugu rubripes	69.33	3.00e-126	444.00
IUUC-Tsy-119624	Tarsius syrichta	61.50	1.00e-119	422.00
IUUC-Tni-119852	Tetraodon nigroviridis	62.98	2.00e-116	411.00
IUUC-Tca-121865	Theobroma cacao	32.25	8.00e-36	144.00
IUUC-Tbe-127632	Tupaia belangeri	74.71	1.00e-132	465.00
IUUC-Ttr-129008	Tursiops truncatus	76.30	4.00e-158	550.00
IUUC-Xtr-132756	Xenopus tropicalis	76.91	7.00e-177	612.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence