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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046401
UUCD1 version UUC-HoS-00228
Ensembl Protein ID ENSP00000420465.1
UniProt Accession Q8N6D2; B2RDG2; Q8NBG3; RN182_HUMAN
Genbank Protein ID BAC03481.1; BAG37909.1; EAW55349.1; AAH30666.1; AAH50030.1
Protein Name E3 ubiquitin-protein ligase RNF182; RING finger protein 182; RING-type E3 ubiquitin transferase RNF182
Genbank Nucleotide ID AK090576; AK315528; AL138718; BC030666; BC050030
Gene Name RNF182
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000180537.12 ENST00000488300.5 ENSP00000420465.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDHINTMentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18298843
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00056 22.0 20 68
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++++   ++ p+vl C H  +a+Cl+k+ +  +s ++ + CP Cr
   Q: 20   CKICYNRYnlkQRKPKVLECCHRVCAKCLYKIIDFGDSPQGVIVCPFCR 68
           99******999777***************99956666689********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.
 E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.
Protein Sequence
(Fasta)
MASQPPEDTA ESQASDELEC KICYNRYNLK QRKPKVLECC HRVCAKCLYK IIDFGDSPQG 60
VIVCPFCRFE TCLPDDEVSS LPDDNNILVN LTCGGKGKKC LPENPTELLL TPKRLASLVS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046401|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGCATGCTG CGGCAGTTGC AACAGGAGAA CCGAGTACCA GTTGCTCAAC ACTTTATCAC 60
TTTGCATTGC TCTTTCTCCT CCCTTAAGTG AATTTCCATT TTGAGGGTAC AGCTCCACAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046401|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
KEGG hsa:221687
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002157 Ailuropoda melanoleuca 95.14 4.00e-105 374.00
IUUC-Apl-003754 Anas platyrhynchos 92.62 5.00e-109 386.00
IUUC-Aca-005163 Anolis carolinensis 90.57 2.00e-104 372.00
IUUC-Ame-010899 Astyanax mexicanus 53.17 1.00e-52 199.00
IUUC-Bta-012609 Bos taurus 92.37 4.00e-95 340.00
IUUC-Cja-019820 Callithrix jacchus 99.60 2.00e-111 394.00
IUUC-Cfa-020982 Canis familiaris 92.13 1.00e-57 214.00
IUUC-Cpo-021400 Cavia porcellus 96.36 8.00e-106 376.00
IUUC-Csa-023232 Chlorocebus sabaeus 98.38 3.00e-109 387.00
IUUC-Cho-024286 Choloepus hoffmanni 95.95 2.00e-106 378.00
IUUC-Dre-027461 Danio rerio 52.55 3.00e-41 161.00
IUUC-Dno-029613 Dasypus novemcinctus 93.04 4.00e-103 367.00
IUUC-Dor-030647 Dipodomys ordii 95.16 4.00e-104 370.00
IUUC-Eca-034110 Equus caballus 97.98 1.00e-108 385.00
IUUC-Eeu-034580 Erinaceus europaeus 97.98 4.00e-109 387.00
IUUC-Fca-036483 Felis catus 96.76 1.00e-107 382.00
IUUC-Fal-037213 Ficedula albicollis 90.98 5.00e-110 390.00
IUUC-Gmo-038766 Gadus morhua 49.44 6.00e-25 105.00
IUUC-Gga-041249 Gallus gallus 94.22 2.00e-100 358.00
IUUC-Gac-042045 Gasterosteus aculeatus 49.61 2.00e-54 205.00
IUUC-Ggo-045237 Gorilla gorilla 100.00 4.00e-112 397.00
IUUC-Itr-048794 Ictidomys tridecemlineatus 94.74 1.00e-105 375.00
IUUC-Lch-050274 Latimeria chalumnae 71.95 3.00e-85 307.00
IUUC-Loc-052382 Lepisosteus oculatus 58.54 1.00e-65 244.00
IUUC-Mcc-055173 Macaca mulatta 99.60 3.00e-111 394.00
IUUC-Meu-056310 Macropus eugenii 47.14 6.00e-48 182.00
IUUC-Mga-059578 Meleagris gallopavo 91.39 2.00e-106 378.00
IUUC-Mmr-060739 Microcebus murinus 98.79 2.00e-109 388.00
IUUC-Mdo-062765 Monodelphis domestica 94.33 5.00e-112 396.00
IUUC-Mmu-064145 Mus musculus 98.38 1.00e-108 385.00
IUUC-Mpu-066170 Mustela putorius furo 97.17 4.00e-108 384.00
IUUC-Mlu-067774 Myotis lucifugus 97.55 4.00e-119 420.00
IUUC-Nle-070141 Nomascus leucogenys 99.19 3.00e-111 394.00
IUUC-Opr-070247 Ochotona princeps 97.18 2.00e-110 391.00
IUUC-Ont-072312 Oreochromis niloticus 47.73 2.00e-58 219.00
IUUC-Oan-073640 Ornithorhynchus anatinus 85.37 4.00e-98 350.00
IUUC-Ocu-074191 Oryctolagus cuniculus 98.38 2.00e-109 388.00
IUUC-Ola-086432 Oryzias latipes 52.42 2.00e-56 211.00
IUUC-Oga-088498 Otolemur garnettii 98.79 3.00e-110 390.00
IUUC-Oar-089917 Ovis aries 93.98 2.00e-102 364.00
IUUC-Ptr-090460 Pan troglodytes 100.00 4.00e-112 397.00
IUUC-Pan-092766 Papio anubis 99.60 3.00e-111 394.00
IUUC-Psi-093943 Pelodiscus sinensis 91.80 3.00e-106 377.00
IUUC-Pfo-096878 Poecilia formosa 54.26 8.00e-60 223.00
IUUC-Pab-097922 Pongo abelii 99.60 5.00e-111 393.00
IUUC-Pca-100996 Procavia capensis 95.78 7.00e-58 216.00
IUUC-Pva-102313 Pteropus vampyrus 96.73 5.00e-118 416.00
IUUC-Rno-105963 Rattus norvegicus 97.57 1.00e-107 382.00
IUUC-Sha-106544 Sarcophilus harrisii 94.33 3.00e-112 397.00
IUUC-Ssc-115614 Sus scrofa 95.95 5.00e-106 376.00
IUUC-Tgu-117096 Taeniopygia guttata 90.98 7.00e-110 389.00
IUUC-Tru-117656 Takifugu rubripes 48.88 2.00e-39 155.00
IUUC-Tsy-119244 Tarsius syrichta 98.38 6.00e-110 390.00
IUUC-Tni-120008 Tetraodon nigroviridis 41.35 9.00e-32 130.00
IUUC-Tbe-127391 Tupaia belangeri 98.38 2.00e-109 388.00
IUUC-Ttr-129115 Tursiops truncatus 94.33 1.00e-104 372.00
IUUC-Vpa-130722 Vicugna pacos 96.36 2.00e-106 378.00
IUUC-Xtr-131837 Xenopus tropicalis 80.89 2.00e-93 334.00
Created Date 25-Jun-2017

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