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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045778
Ensembl Protein ID ENSP00000244458.2
UniProt Accession Q9BY11; Q9P2G8; PACN1_HUMAN
Genbank Protein ID AAK29206.1; BAA92617.2; CAD38895.1; AAH40228.1
Protein Name Protein kinase C and casein kinase substrate in neurons protein 1; Syndapin-1
Genbank Nucleotide ID AF242529; AB037800; AL834211; BC040228
Gene Name PACSIN1; KIAA1379
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000124507.10 ENST00000244458.6 ENSP00000244458.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.10e-14 55.8 389 444
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v++lydy++q++deL++k+Gd ++ +  ee ++gW++g + ++g+ Gl P+n+ve +
   Q: 389  RVRALYDYDGQEQDELSFKAGDELTKL-GEEDEQGWCRG-RLDSGQLGLYPANYVEAI 444
           699************************.***********.59*************975 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
 Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
Protein Sequence
(Fasta)
MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA KIEKAYGQQL 60
TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE VKNNLLNEDL EKVKNWQKDA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045778|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCACGCCTCC TCCTCATCCT TCCCCCCTCT CCGCCTCAGC TCTGACCTTC CTCCTTCCCG 60
CAGCCCCGGC GAGATCCCAG AGCGACGCGG TGGCGGCGGC AGCGCCAGCC CCCTCCTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045778|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
KW-0771--Synaptosome
Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028518--PACSIN1
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0043679--C:axon terminus
GO:0030054--C:cell junction
GO:0030137--C:COPI-coated vesicle
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0043209--C:myelin sheath
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0032587--C:ruffle membrane
GO:0045202--C:synapse
GO:0005543--F:phospholipid binding
GO:0007015--P:actin filament organization
GO:0090002--P:establishment of protein localization to plasma membrane
GO:0045806--P:negative regulation of endocytosis
GO:0048812--P:neuron projection morphogenesis
GO:0097320--P:plasma membrane tubulation
GO:1900006--P:positive regulation of dendrite development
GO:0072657--P:protein localization to membrane
GO:0030100--P:regulation of endocytosis
GO:0048488--P:synaptic vesicle endocytosis
KEGG hsa:29993
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001861 Ailuropoda melanoleuca 87.50 0.00e+00 773.00
IUUC-Apl-003667 Anas platyrhynchos 83.49 0.00e+00 695.00
IUUC-Aca-005229 Anolis carolinensis 80.94 0.00e+00 714.00
IUUC-Ame-011410 Astyanax mexicanus 74.66 1.00e-180 626.00
IUUC-Bta-013509 Bos taurus 94.14 0.00e+00 749.00
IUUC-Cja-019659 Callithrix jacchus 98.65 0.00e+00 838.00
IUUC-Cfa-020396 Canis familiaris 96.85 0.00e+00 798.00
IUUC-Cpo-022376 Cavia porcellus 96.85 0.00e+00 795.00
IUUC-Csa-023701 Chlorocebus sabaeus 99.32 0.00e+00 813.00
IUUC-Dre-027456 Danio rerio 75.62 0.00e+00 679.00
IUUC-Eca-033679 Equus caballus 90.38 0.00e+00 724.00
IUUC-Fca-036314 Felis catus 96.85 0.00e+00 801.00
IUUC-Fal-037300 Ficedula albicollis 84.98 0.00e+00 737.00
IUUC-Gmo-038571 Gadus morhua 68.58 4.00e-164 571.00
IUUC-Gga-040626 Gallus gallus 85.43 0.00e+00 690.00
IUUC-Gac-041445 Gasterosteus aculeatus 70.09 1.00e-168 586.00
IUUC-Ggo-045557 Gorilla gorilla 100.00 0.00e+00 821.00
IUUC-Itr-048856 Ictidomys tridecemlineatus 97.75 0.00e+00 803.00
IUUC-Lch-050070 Latimeria chalumnae 71.28 0.00e+00 666.00
IUUC-Loc-051764 Lepisosteus oculatus 79.64 0.00e+00 697.00
IUUC-Laf-054465 Loxodonta africana 94.61 0.00e+00 796.00
IUUC-Mcc-055324 Macaca mulatta 99.10 0.00e+00 814.00
IUUC-Meu-056348 Macropus eugenii 90.09 0.00e+00 740.00
IUUC-Mga-059285 Meleagris gallopavo 85.68 0.00e+00 677.00
IUUC-Mmr-061367 Microcebus murinus 96.62 0.00e+00 752.00
IUUC-Mdo-062432 Monodelphis domestica 57.72 3.00e-138 484.00
IUUC-Mmu-064347 Mus musculus 95.05 0.00e+00 820.00
IUUC-Mpu-066864 Mustela putorius furo 97.07 0.00e+00 801.00
IUUC-Nle-070027 Nomascus leucogenys 99.29 0.00e+00 771.00
IUUC-Ont-072188 Oreochromis niloticus 72.71 0.00e+00 640.00
IUUC-Ocu-074297 Oryctolagus cuniculus 96.85 0.00e+00 766.00
IUUC-Ola-087188 Oryzias latipes 72.71 2.00e-163 568.00
IUUC-Oga-088856 Otolemur garnettii 97.75 0.00e+00 777.00
IUUC-Oar-090278 Ovis aries 86.94 0.00e+00 650.00
IUUC-Pan-092056 Papio anubis 99.32 0.00e+00 813.00
IUUC-Pfo-097528 Poecilia formosa 69.80 4.00e-158 550.00
IUUC-Pab-098202 Pongo abelii 99.55 0.00e+00 817.00
IUUC-Pca-100881 Procavia capensis 96.17 0.00e+00 787.00
IUUC-Pva-102181 Pteropus vampyrus 97.30 0.00e+00 799.00
IUUC-Rno-105295 Rattus norvegicus 92.79 0.00e+00 769.00
IUUC-Sha-107163 Sarcophilus harrisii 76.42 0.00e+00 654.00
IUUC-Ssc-115685 Sus scrofa 96.17 0.00e+00 795.00
IUUC-Tgu-116524 Taeniopygia guttata 77.80 0.00e+00 647.00
IUUC-Tru-118248 Takifugu rubripes 69.87 4.00e-155 541.00
IUUC-Tni-120717 Tetraodon nigroviridis 70.69 4.00e-159 554.00
IUUC-Ttr-129069 Tursiops truncatus 95.51 0.00e+00 745.00
IUUC-Xtr-132759 Xenopus tropicalis 71.14 0.00e+00 649.00
Created Date 25-Jun-2017

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