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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046575
Ensembl Protein ID ENSP00000367808.4
UniProt Accession Q6NZ36; A6PW39; A6PW40; A6PW41; A8MQT6; F2Z2L4; Q6ZT64; Q71M24; Q96ND7; FAP20_HUMAN
Genbank Protein ID BAB70965.1; BAC86730.1; AAQ04817.1; EAW56125.1; AAH66360.1; AAI03993.1
Protein Name Fanconi anemia core complex-associated protein 20; FANCA-associated protein of 20 kDa; Fanconi anemia-associated protein of 20 kDa
Genbank Nucleotide ID AK055593; AK126870; AF461903; AL590822; BC066360; BC078145
Gene Name FAAP20; C1orf86; FP7162
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162585.16 ENST00000428120.5 ENSP00000405430.1
ENSG00000162585.16 ENST00000414253.5 ENSP00000410450.1
ENSG00000162585.16 ENST00000400918.7 ENSP00000383709.3
ENSG00000162585.16 ENST00000378546.8 ENSP00000367808.4
ENSG00000162585.16 ENST00000440825.6 ENSP00000410740.2
ENSG00000162585.16 ENST00000420515.1 ENSP00000409721.1
ENSG00000162585.16 ENST00000400919.7 ENSP00000383710.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsiteCircNetmiRTarBasemicroRNA
TRANSFACTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 22396592
Classification
Family E-value Score Start End
UBD/ZnF/UBZ 3.30e-07 32.1 145 171
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 2    lvCPvCqkm....vdqtdfeeHlDeCl 24
            +CP+Cqk+    ++q d+++Hl++Cl
   Q: 145  RSCPMCQKEfaprLTQLDVDSHLAQCL 171
           69************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
 Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
Protein Sequence
(Fasta)
MEAARRPRLG LSRRRPRPAG GPSGGRPWFL LGGDERERLW AELLRTVSPE LILDHEVPSL 60
PAFPGQEPRC GPEPTEVFTV GPKTFSWTPF PPDLWGPGRS YRLLHGAGGH LESPARSLPQ 120
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Protein Fasta Sequence


>IUUC-Hsa-046575|UBD,UBZ|Homo sapiens
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Nucleotide Sequence
(Fasta)
GAACATGGAT GCCTCGCTTT TCAGAGACTC GCGTTCTTGG AACTTACACC CTTTTGGGTT 60
TGCTATTTTT ACCCACCCTG AGCCTTCCGG TCTCCATGGC GACGCCTCCA AACAGCAGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046575|UBD,UBZ|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR031491--FANCA_interact
IPR031490--UBZ_FAAP20
Pfam

PF15751--FANCA_interact
PF15750--UBZ_FAAP20
Gene Ontology

GO:0030054--C:cell junction
GO:0005694--C:chromosome
GO:0043240--C:Fanconi anaemia nuclear complex
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0036297--P:interstrand cross-link repair
GO:0019985--P:translesion synthesis
KEGG hsa:199990
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002409 Ailuropoda melanoleuca 56.45 9.00e-13 64.70
IUUC-Aly-005778 Arabidopsis lyrata 34.29 1.60e-01 27.30
IUUC-Ani-009438 Aspergillus nidulans 34.78 1.90e-01 28.90
IUUC-Bta-013416 Bos taurus 46.95 4.00e-23 101.00
IUUC-Cja-019117 Callithrix jacchus 80.95 4.00e-64 238.00
IUUC-Cpo-021546 Cavia porcellus 69.64 4.00e-17 79.00
IUUC-Csa-024066 Chlorocebus sabaeus 92.16 1.00e-76 278.00
IUUC-Dno-029273 Dasypus novemcinctus 76.92 7.00e-18 82.00
IUUC-Ete-033066 Echinops telfairi 50.00 4.00e-33 134.00
IUUC-Eca-033947 Equus caballus 57.23 6.00e-30 123.00
IUUC-Eeu-034567 Erinaceus europaeus 58.04 1.00e-31 128.00
IUUC-Gac-041654 Gasterosteus aculeatus 52.94 4.00e-09 53.90
IUUC-Ggo-045315 Gorilla gorilla 99.34 4.00e-83 300.00
IUUC-Itr-048140 Ictidomys tridecemlineatus 56.96 2.00e-30 125.00
IUUC-Laf-054078 Loxodonta africana 58.48 6.00e-32 130.00
IUUC-Mmr-060675 Microcebus murinus 66.88 2.00e-47 181.00
IUUC-Mmu-063902 Mus musculus 53.70 2.00e-32 131.00
IUUC-Nle-069135 Nomascus leucogenys 97.39 1.00e-82 298.00
IUUC-Oga-088370 Otolemur garnettii 67.28 5.00e-51 193.00
IUUC-Oar-090037 Ovis aries 66.67 2.00e-15 76.30
IUUC-Ptr-091600 Pan troglodytes 95.86 4.00e-79 286.00
IUUC-Pan-091731 Papio anubis 94.34 6.00e-82 296.00
IUUC-Pfo-096538 Poecilia formosa 51.28 3.00e-07 47.80
IUUC-Pab-098384 Pongo abelii 96.69 3.00e-80 291.00
IUUC-Pca-100684 Procavia capensis 51.48 1.00e-34 139.00
IUUC-Rno-105623 Rattus norvegicus 52.12 8.00e-33 133.00
IUUC-Sha-107222 Sarcophilus harrisii 65.79 1.00e-12 65.50
Created Date 25-Jun-2017

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